Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer von Feig, Christine, Jones, James O., Kraman, Matthew, Wells, Richard J. B., Deonarine, Andrew, Chan, Derek S., Connell, Claire M., Roberts, Edward W., Qi Zhao, Caballero, Otavia L., Teichmann, Sarah A., Janowitz, Tobias, Jodrell, Duncan I., Tuveson, David A., Fearon, Douglas T.

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Notch2 is required for the proliferation of cardiac neural crest‐derived smooth muscle cells von Varadkar, Prajakta, Kraman, Matthew, Despres, Daryl, Ma, Ge, Lozier, Julie, McCright, Brent

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Functional conservation of Notch1 and Notch2 intracellular domains von Kraman, Matthew, McCright, Brent

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CD27 mediates interleukin-2-independent clonal expansion of the CD8⁺ T cell without effector differentiation von Carr, James M, Carrasco, Marlene J, Thaventhiran, James E.D, Bambrough, Paul J, Kraman, Matthew, Edwards, Alexander D, Al-Shamkhani, Aymen, Fearon, Douglas T

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BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiation von Logarajah, Suresh, Hunter, Patricia, Kraman, Matthew, Steele, Dawn, Lakhani, Sunil, Bobrow, Lynda, Venkitaraman, Ashok, Wagner, Simon

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FS118, a Bispecific Antibody Targeting LAG-3 and PD-L1, Enhances T-Cell Activation Resulting in Potent Antitumor Activity von Kraman, Matthew, Faroudi, Mustapha, Allen, Natalie L, Kmiecik, Katarzyna, Gliddon, Daniel, Seal, Claire, Koers, Alexander, Wydro, Mateusz M, Batey, Sarah, Winnewisser, Julia, Young, Lesley, Tuna, Mihriban, Doody, Jacqueline, Morrow, Michelle, Brewis, Neil

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Secondary Replicative Function of CD8⁺ T Cells That Had Developed an Effector Phenotype von Bannard, Oliver, Kraman, Matthew, Fearon, Douglas T

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Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein-α von Kraman, Matthew, Bambrough, Paul J, Arnold, James N, Roberts, Edward W, Magiera, Lukasz, Jones, James O, Gopinathan, Aarthi, Tuveson, David A, Fearon, Douglas T

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Tumoral Immune Suppression by Macrophages Expressing Fibroblast Activation Protein-α and Heme Oxygenase-1 von ARNOLD, James N, MAGIERA, Lukasz, KRAMAN, Matthew, FEARON, Douglas T

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Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia von Roberts, Edward W, Deonarine, Andrew, Jones, James O, Denton, Alice E, Feig, Christine, Lyons, Scott K, Espeli, Marion, Kraman, Matthew, McKenna, Brendan, Wells, Richard J B, Zhao, Qi, Caballero, Otavia L, Larder, Rachel, Coll, Anthony P, O'Rahilly, Stephen, Brindle, Kevin M, Teichmann, Sarah A, Tuveson, David A, Fearon, Douglas T

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A common region of 10p deleted in DiGeorge and velocardiofacial syndromes von Daw, Sara C.M, Taylor, Catherine, Kraman, Matthew, Call, Kathy, Mao, Jen-i, Schuffenhauer, Simone, Meitinger, Thomas, Lipson, Tony, Goodship, Judith, Scambler, Peter

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Pathways of memory CD8+ T‐cell development von Bannard, Oliver, Kraman, Matthew, Fearon, Douglas

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Generation of Fcabs targeting human and murine LAG-3 as building blocks for novel bispecific antibody therapeutics von Everett, Katy L., Kraman, Matthew, Wollerton, Francisca P.G., Zimarino, Carlo, Kmiecik, Katarzyna, Gaspar, Miguel, Pechouckova, Sarka, Allen, Natalie L., Doody, Jacqueline F., Tuna, Mihriban

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The protein phosphatase 2A B56[gamma] regulatory subunit is required for heart development von Varadkar, Prajakta, Despres, Daryl, Kraman, Matthew, Lozier, Julie, Phadke, Aditi, Nagaraju, Kanneboyina, Mccright, Brent

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The protein phosphatase 2A B56γ regulatory subunit is required for heart development von Varadkar, Prajakta, Despres, Daryl, Kraman, Matthew, Lozier, Julie, Phadke, Aditi, Nagaraju, Kanneboyina, Mccright, Brent

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Abstract 5651: A LAG-3/PD-L1 bispecific antibody inhibits tumor growth in two syngeneic colon carcinoma models von Kraman, Matthew, Kmiecik, Katarzyna, Zimarino, Carlo, Everett, Katy, Faroudi, Mustapha, Wydro, Mateusz, Doody, Jacqueline

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Abstract 2399: LAG-3/PD-L1 mAb2 can overcome PD-L1-mediated compensatory upregulation of LAG-3 induced by single-agent checkpoint blockade von Faroudi, Mustapha, Kraman, Matthew, Fosh, Natalie, Reader, Claire, Gliddon, Daniel, Seal, Claire, Lucas, Christa, Koers, Alexander, Wydro, Mateusz, Morrow, Michelle, Brewis, Neil

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Abstract 2719: Dual blockade of PD-L1 and LAG-3 with FS118, a unique bispecific antibody, induces CD8+ T-cell activation and modulates the tumor microenvironment to promote antitum... von Kraman, Matthew, Fosh, Natalie, Kmiecik, Katarzyna, Everett, Katy, Zimarino, Carlo, Faroudi, Mustapha, Wydro, Mateusz, Koers, Alexander, Young, Lesley, Gliddon, Daniel, Morrow, Michelle, Doody, Jacqueline, Tuna, Mihriban, Brewis, Neil

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Cutting edge: Virus-specific CD8+ T cell clones and the maintenance of replicative function during a persistent viral infection von Bannard, Oliver, Kraman, Matthew, Fearon, Douglas T

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1353 Targeting complement factor H mediated tumor immune and complement evasion as a next generation approach von Kraman, Matthew, Zimarino, Carlo, Minns, Danielle, Dias, Jorge, Povall, Chelsea, Graves, Helen, Holub, Bradley, Minter, Ralph, Galson, Jacob, Osbourn, Jane, Finch, Donna

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