The genomic landscape of response to EGFR blockade in colorectal cancer von Bertotti, Andrea, Papp, Eniko, Jones, Siân, Adleff, Vilmos, Anagnostou, Valsamo, Lupo, Barbara, Sausen, Mark, Phallen, Jillian, Hruban, Carolyn A., Tokheim, Collin, Niknafs, Noushin, Nesselbush, Monica, Lytle, Karli, Sassi, Francesco, Cottino, Francesca, Migliardi, Giorgia, Zanella, Eugenia R., Ribero, Dario, Russolillo, Nadia, Mellano, Alfredo, Muratore, Andrea, Paraluppi, Gianluca, Salizzoni, Mauro, Marsoni, Silvia, Kragh, Michael, Lantto, Johan, Cassingena, Andrea, Li, Qing Kay, Karchin, Rachel, Scharpf, Robert, Sartore-Bianchi, Andrea, Siena, Salvatore, Diaz, Luis A., Trusolino, Livio, Velculescu, Victor E.

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Sym015: A Highly Efficacious Antibody Mixture against MET -Amplified Tumors von Poulsen, Thomas Tuxen, Grandal, Michael Monrad, Skartved, Niels Jørgen Østergaard, Hald, Rikke, Alifrangis, Lene, Koefoed, Klaus, Lindsted, Trine, Fröhlich, Camilla, Pollmann, Sofie Ellebæk, Eriksen, Karsten Wessel, Dahlman, Anna, Jacobsen, Helle Jane, Bouquin, Thomas, Pedersen, Mikkel Wandahl, Horak, Ivan David, Lantto, Johan, Kragh, Michael

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Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation von Jones, Sylwia, King, Peter J., Antonescu, Costin N., Sugiyama, Michael G., Bhamra, Amandeep, Surinova, Silvia, Angelopoulos, Nicos, Kragh, Michael, Pedersen, Mikkel W., Hartley, John A., Futter, Clare E., Hochhauser, Daniel

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The First-in-class Anti-EGFR Antibody Mixture Sym004 Overcomes Cetuximab Resistance Mediated by EGFR Extracellular Domain Mutations in Colorectal Cancer von Sánchez-Martín, Francisco J, Bellosillo, Beatriz, Gelabert-Baldrich, Mariona, Dalmases, Alba, Cañadas, Israel, Vidal, Joana, Martinez, Alejandro, Argilés, Guillem, Siravegna, Giulia, Arena, Sabrina, Koefoed, Klaus, Visa, Laura, Arpí, Oriol, Horak, Ivan David, Iglesias, Mar, Stroh, Christopher, Kragh, Michael, Rovira, Ana, Albanell, Joan, Tabernero, Josep, Bardelli, Alberto, Montagut, Clara

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Simultaneous targeting of HER family pro-survival signaling with Pan-HER antibody mixture is highly effective in TNBC: a preclinical trial with PDXs von Reddy, Tejaswini P., Choi, Dong S., Anselme, Ann C., Qian, Wei, Chen, Wen, Lantto, Johan, Horak, Ivan D., Kragh, Michael, Chang, Jenny C., Rosato, Roberto R.

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Pan‐HER—An antibody mixture targeting EGFR, HER2 and HER3 abrogates preformed and ligand‐induced EGFR homo‐ and heterodimers von Ellebæk, Sofie, Brix, Susanne, Grandal, Michael, Lantto, Johan, Horak, Ivan D., Kragh, Michael, Poulsen, Thomas Tuxen

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Sym004, a Novel EGFR Antibody Mixture, Can Overcome Acquired Resistance to Cetuximab von Iida, Mari, Brand, Toni M, Starr, Megan M, Li, Chunrong, Huppert, Evan J, Luthar, Neha, Pedersen, Mikkel W, Horak, Ivan D, Kragh, Michael, Wheeler, Deric L

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Interleukin 21: combination strategies for cancer therapy von Smyth, Mark J, Sivakumar, Pallavur V, Skak, Kresten, Kragh, Michael, Hausman, Diana

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Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor von Koefoed, Klaus, Steinaa, Lucilla, Søderberg, Josefine Nielsen, Kjær, Ida, Jacobsen, Helle Jane, Meijer, Per-Johan, Haurum, John Sørensen, Jensen, Allan, Kragh, Michael, Andersen, Peter Sejer, Pedersen, Mikkel Wandahl

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Preclinical Pharmacokinetics and Safety of Sym004: A Synergistic Antibody Mixture Directed against Epidermal Growth Factor Receptor von SKARTVED, Niels Jørgen Østergaard, JACOBSEN, Helle Jane, PEDERSEN, Mikkel Wandahl, JENSEN, Pernille Foged, SEN, Jette Wagtberg, JORGENSEN, Thomas Kjærsgaard, HEY, Adam, KRAGH, Michael

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Sym004, a novel anti-EGFR antibody mixture, augments radiation response in human lung and head and neck cancers von Huang, Shyhmin, Peet, Chimera R, Saker, Jarob, Li, Chunrong, Armstrong, Eric A, Kragh, Michael, Pedersen, Mikkel W, Harari, Paul M

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Sym004: A Novel Synergistic Anti-Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy von PEDERSEN, Mikkel Wandahl, JACOBSEN, Helle Jane, KOEFOED, Klaus, HEY, Adam, PYKE, Charles, HAURUM, John Sørensen, KRAGH, Michael

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HER-Family Ligands Promote Acquired Resistance to Trastuzumab in Gastric Cancer von Sampera, Aïda, Sánchez-Martín, Francisco Javier, Arpí, Oriol, Visa, Laura, Iglesias, Mar, Menéndez, Sílvia, Gaye, Élisabeth, Dalmases, Alba, Clavé, Sergi, Gelabert-Baldrich, Mariona, Poulsen, Thomas Tuxen, Kragh, Michael, Bellosillo, Beatriz, Albanell, Joan, Rovira, Ana, Montagut, Clara

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Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity von Jacobsen, Helle J, Poulsen, Thomas T, Dahlman, Anna, Kjær, Ida, Koefoed, Klaus, Sen, Jette W, Weilguny, Dietmar, Bjerregaard, Bolette, Andersen, Christina R, Horak, Ivan D, Pedersen, Mikkel W, Kragh, Michael, Lantto, Johan

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Abstract 357: Pan-HER, an antibody mixture simultaneously targeting EGFR, HER2, and HER3, is highly effective in triple negative breast cancer patient-derived xenografts von Rosato, Roberto R., Choi, Don S., Qian, Wei, Chen, Wen, Lantto, Johan, Horak, Ivan D., Kragh, Michael, Chang, Jenny C.

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CD4 + and CD8a + PET imaging predicts response to novel PD-1 checkpoint inhibitor: studies of Sym021 in syngeneic mouse cancer models von Kristensen, Lotte K, Fröhlich, Camilla, Christensen, Camilla, Melander, Maria C, Poulsen, Thomas T, Galler, Gunther R, Lantto, Johan, Horak, Ivan D, Kragh, Michael, Nielsen, Carsten H, Kjaer, Andreas

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Abstract LB-216: Protein pathway activation analysis of a panel of patient-derived epithelial tumor models identifies signatures of response to ErbB1-3 co-targeting von Calvert, Valerie S., Fröhlich, Camilla, Poulsen, Thomas T., Pedersen, Mikkel W., Kragh, Michael, Horak, Ivan D., Petricoin, Emanuel F.

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Forty‐nine gastric cancer cell lines with integrative genomic profiling for development of c‐MET inhibitor von Kim, Hyun Jeong, Kang, Sun Kyoung, Kwon, Woo Sun, Kim, Tae Soo, Jeong, Inhye, Jeung, Hei‐Cheul, Kragh, Michael, Horak, Ivan D., Chung, Hyun Cheol, Rha, Sun Young

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Population pharmacokinetics (popPK) of Sym004 to evaluate the effect of intrinsic and extrinsic factors on exposure in metastatic colorectal cancer (mCRC) von Alifrangis, Lene, Schoemacker, Rik, Skartved, Niels Jorgen Ostergaard, Hald, Rikke, Düring, Maria, Montagut, Clara, Argiles, Guillem, Kopetz, Scott, Horak, Ivan David, Kragh, Michael, Wade, Janet R

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An ERBB1-3 Neutralizing Antibody Mixture With High Activity Against Drug-Resistant HER2+ Breast Cancers With ERBB Ligand Overexpression von Schwarz, Luis J, Hutchinson, Katherine E, Rexer, Brent N, Estrada, Mónica Valeria, Gonzalez Ericsson, Paula I, Sanders, Melinda E, Dugger, Teresa C, Formisano, Luigi, Guerrero-Zotano, Angel, Red-Brewer, Monica, Young, Christian D, Lantto, Johan, Pedersen, Mikkel W, Kragh, Michael, Horak, Ivan D, Arteaga, Carlos L

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