Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC von Socinski, Mark A, Jotte, Robert M, Cappuzzo, Federico, Orlandi, Francisco, Stroyakovskiy, Daniil, Nogami, Naoyuki, Rodríguez-Abreu, Delvys, Moro-Sibilot, Denis, Thomas, Christian A, Barlesi, Fabrice, Finley, Gene, Kelsch, Claudia, Lee, Anthony, Coleman, Shelley, Deng, Yu, Shen, Yijing, Kowanetz, Marcin, Lopez-Chavez, Ariel, Sandler, Alan, Reck, Martin

Volltext

Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial von Rittmeyer, Achim, MD, Barlesi, Fabrice, PhD, Waterkamp, Daniel, MD, Park, Keunchil, MD, Ciardiello, Fortunato, MD, von Pawel, Joachim, MD, Gadgeel, Shirish M, MD, Hida, Toyoaki, PhD, Kowalski, Dariusz M, PhD, Dols, Manuel Cobo, MD, Cortinovis, Diego L, PhD, Leach, Joseph, MD, Polikoff, Jonathan, MD, Barrios, Carlos, MD, Kabbinavar, Fairooz, MD, Frontera, Osvaldo Arén, MD, De Marinis, Filippo, MD, Turna, Hande, MD, Lee, Jong-Seok, MD, Ballinger, Marcus, PhD, Kowanetz, Marcin, PhD, He, Pei, PhD, Chen, Daniel S, MD, Sandler, Alan, MD, Gandara, David R, Dr

Volltext

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients von Herbst, Roy S., Soria, Jean-Charles, Kowanetz, Marcin, Fine, Gregg D., Hamid, Omid, Gordon, Michael S., Sosman, Jeffery A., McDermott, David F., Powderly, John D., Gettinger, Scott N., Kohrt, Holbrook E. K., Horn, Leora, Lawrence, Donald P., Rost, Sandra, Leabman, Maya, Xiao, Yuanyuan, Mokatrin, Ahmad, Koeppen, Hartmut, Hegde, Priti S., Mellman, Ira, Chen, Daniel S., Hodi, F. Stephen

Volltext

Safety and clinical activity of atezolizumab monotherapy in metastatic non-small-cell lung cancer: final results from a phase I study von Horn, Leora, Gettinger, Scott N., Gordon, Michael S., Herbst, Roy S., Gandhi, Leena, Felip, Enriqueta, Sequist, Lecia V., Spigel, David R., Antonia, Scott J., Balmanoukian, Ani, Cassier, Philippe A., Liu, Bo, Kowanetz, Marcin, O'Hear, Carol, Fassò, Marcella, Grossman, William, Sandler, Alan, Soria, Jean-Charles

Volltext

Molecular and Histopathological Characterization of the Tumor Immune Microenvironment in Advanced Stage of Malignant Pleural Mesothelioma von Patil, Namrata S., Righi, Luisella, Koeppen, Hartmut, Zou, Wei, Izzo, Stefania, Grosso, Federica, Libener, Roberta, Loiacono, Marco, Monica, Valentina, Buttigliero, Consuelo, Novello, Silvia, Hegde, Priti S., Papotti, Mauro, Kowanetz, Marcin, Scagliotti, Giorgio V.

Volltext

C-reactive protein reduction post treatment is associated with improved survival in atezolizumab (anti-PD-L1) treated non-small cell lung cancer patients von Patil, Namrata S., Zou, Wei, Mocci, Simonetta, Sandler, Alan, Ballinger, Marcus, Flynn, Susan, Kowanetz, Marcin, Hegde, Priti S.

Volltext

Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF–induced neutrophil recruitment von Phan, Vernon T., Wu, Xiumin, Cheng, Jason H., Sheng, Rebecca X., Chung, Alicia S., Zhuang, Guanglei, Tran, Christopher, Song, Qinghua, Kowanetz, Marcin, Sambrone, Amy, Tan, Martha, Meng, Y. Gloria, Jackson, Erica L., Peale, Franklin V., Junttila, Melissa R., Ferrara, Napoleone

Volltext

Late-differentiated effector neoantigen-specific CD8+ T cells are enriched in peripheral blood of non-small cell lung carcinoma patients responding to atezolizumab treatment von Fehlings, Michael, Jhunjhunwala, Suchit, Kowanetz, Marcin, O’Gorman, William E., Hegde, Priti S., Sumatoh, Hermi, Lee, Boon Heng, Nardin, Alessandra, Becht, Etienne, Flynn, Susan, Ballinger, Marcus, Newell, Evan W., Yadav, Mahesh

Volltext

Id2 and Id3 Define the Potency of Cell Proliferation and Differentiation Responses to Transforming Growth Factor β and Bone Morphogenetic Protein von Kowanetz, Marcin, Valcourt, Ulrich, Bergström, Rosita, Heldin, Carl-Henrik, Moustakas, Aristidis

Volltext

IMpower131: Primary PFS and safety analysis of a randomized phase III study of atezolizumab + carboplatin + paclitaxel or nab-paclitaxel vs carboplatin + nab-paclitaxel as 1L thera... von Jotte, Robert M., Cappuzzo, Federico, Vynnychenko, Ihor, Stroyakovskiy, Daniil, Rodriguez Abreu, Delvys, Hussein, Maen A., Soo, Ross A., Conter, Henry Jacob, Kozuki, Toshiyuki, Silva, Carlos, Graupner, Vilma, Sun, Shawn, Lin, Ray S, Kelsch, Claudia, Kowanetz, Marcin, Hoang, Tien, Sandler, Alan, Socinski, Mark A.

Volltext

Overall survival (OS) analysis of IMpower150, a randomized Ph 3 study of atezolizumab (atezo) + chemotherapy (chemo) ± bevacizumab (bev) vs chemo + bev in 1L nonsquamous (NSQ) NSCL... von Socinski, Mark A., Jotte, Robert M., Cappuzzo, Federico, Orlandi, Francisco Jorquera, Stroyakovskiy, Daniil, Nogami, Naoyuki, Rodriguez-Abreu, Delvys, Moro-Sibilot, Denis, Thomas, Christian A., Barlesi, Fabrice, Finley, Gene Grant, Kelsch, Claudia, Lee, Anthony, Coleman, Shelley, Shen, Yijing, Kowanetz, Marcin, Lopez-Chavez, Ariel, Sandler, Alan, Reck, Martin

Volltext

Stable Expression of Angiopoietin-1 and Other Markers by Cultured Pericytes: Phenotypic Similarities to a Subpopulation of Cells in Maturing Vessels During Later Stages of Angiogen... von Sundberg, Christian, Kowanetz, Marcin, Brown, Lawrence F, Detmar, Michael, Dvorak, Harold F

Volltext

The Mechanism of Nuclear Export of Smad3 Involves Exportin 4 and Ran von Kurisaki, Akira, Kurisaki, Keiko, Kowanetz, Marcin, Sugino, Hiromu, Yoneda, Yoshihiro, Heldin, Carl-Henrik, Moustakas, Aristidis

Volltext

Clinical activity, safety and predictive biomarkers of the engineered antibody MPDL3280A (anti-PDL1) in non-small cell lung cancer (NSCLC): update from a phase Ia study von Horn, Leora, Spigel, David R., Gettinger, Scott N., Antonia, Scott Joseph, Gordon, Michael S., Herbst, Roy S., Sequist, Lecia V., Chappey, Colombe, Kowanetz, Marcin, Sandler, Alan, Soria, Jean-Charles

Volltext

Efficacy, safety and predictive biomarker results from a randomized phase II study comparing MPDL3280A vs docetaxel in 2L/3L NSCLC (POPLAR) von Spira, Alexander I., Park, Keunchil, Mazières, Julien, Vansteenkiste, Johan F., Rittmeyer, Achim, Ballinger, Marcus, Waterkamp, Daniel, Kowanetz, Marcin, Mokatrin, Ahmad, Fehrenbacher, Louis

Volltext

Blocking Vascular Endothelial Growth Factor-A Inhibits the Growth of Pituitary Adenomas and Lowers Serum Prolactin Level in a Mouse Model of Multiple Endocrine Neoplasia Type 1 von Korsisaari, Nina, Ross, Jed, Wu, Xiumin, Kowanetz, Marcin, Pal, Navneet, Hall, Linda, Eastham-Anderson, Jeffrey, Forrest, William F, Van Bruggen, Nicholas, Peale, Franklin V, Ferrara, Napoleone

Volltext

605 Systemically administered HER2-targeted ISACs provoke a rapid, local response that engages the innate and adaptive arms of the immune system to eradicate tumors in preclinical... von LeBlanc, Heidi, Pearson, Cecelia, Kenkel, Justin, Blum, LIsa, Ho, Po, Luo, Angela, Laura, Richard, Zhou, Matthew, Gregorio, Joshua, Luo, Andrew, Ackerman, Shelley, Safina, Brian, Dornan, David, Alonso, Michael, Kowanetz, Marcin

Volltext

784 BDC-2034: discovery of a CEA-targeting immune-stimulating antibody conjugate (ISAC) for solid tumors von Mallet, William, Gadkari, Rishali, Pearson, Cecelia, Torrez Dulgeroff, Laughing Bear, Luo, Angela, Luo, AAngela Luondrew, Melrose, Jennifer, Nolin, Jess, Lee, Arthur, Zhou, Matthew, Anand, Puneet, Sarma, Ganapathy, Henning, Karla, Blum, Lisa, Chapin, Steven, Bogaert, Liz, Ackerman, Shelley, Kudirka, Romas, Shen, Yuyi, Husain, Amreen, Perez, Edith, Kowanetz, Marcin, Alonso, Michael, Safina, Brian, Dornan, David

Volltext

PD-L1 Inhibition With MPDL3280A for Solid Tumors von Cha, Edward, Wallin, Jeffrey, Kowanetz, Marcin

Volltext

401 Phase 1/2 study of novel HER2-targeting, TLR7/8 immune-stimulating antibody conjugate (ISAC) BDC-1001 with or without immune checkpoint inhibitor in patients with advanced HER2... von Sharma, Manish, Dumbrava, Ecaterina Ileana, Carvajal, Richard, Catenacci, Daniel, Emens, Leisha, Hanna, Glenn, Juric, Dejan, Kang, Yoon-Koo, Lee, Jeeyun, Lee, Keun-Wook, Li, Bob, Moore, Kathleen, Pegram, Mark, Pohlmann, Paula, Rasco, Drew, Spira, Alexander, Tan, Antoinette, Wang, Ding, Ackerman, Shelley, LeBlanc, Heidi, Dornan, David, Kowanetz, Marcin, Alonso, Michael, Perez, Edith

Volltext