Targeting P-selectin and interleukin-1β in mice with sickle cell disease: effects on vaso-occlusion, liver injury and organ iron deposition von Gotardo, Érica M F, Torres, Lidiane S, Zaidan, Bruna Cunha, Gushiken, Lucas F S, Brito, Pâmela L, Leonardo, Flavia C, Pellizzon, Claudia H, Millholland, John, Agoulnik, Sergei, Kovarik, Jiri, Costa, Fernando F, Conran, Nicola

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The Potent Protein Kinase C-Selective Inhibitor AEB071 (Sotrastaurin) Represents a New Class of Immunosuppressive Agents Affecting Early T-Cell Activation von Evenou, Jean-Pierre, Wagner, Jürgen, Zenke, Gerhard, Brinkmann, Volker, Wagner, Kathrin, Kovarik, Jiri, Welzenbach, Karl A, Weitz-Schmidt, Gabriele, Guntermann, Christine, Towbin, Harry, Cottens, Sylvain, Kaminski, Sandra, Letschka, Thomas, Lutz-Nicoladoni, Christina, Gruber, Thomas, Hermann-Kleiter, Natascha, Thuille, Nikolaus, Baier, Gottfried

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Orally Bioavailable Isothioureas Block Function of the Chemokine Receptor CXCR4 In Vitro and In Vivo von Thoma, Gebhard, Streiff, Markus B, Kovarik, Jiri, Glickman, Fraser, Wagner, Trixie, Beerli, Christian, Zerwes, Hans-Günter

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Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1 von Fiorina, Paolo, Jurewicz, Mollie, Vergani, Andrea, Petrelli, Alessandra, Carvello, Michele, D'Addio, Francesca, Godwin, Jonathan G, Law, Kenneth, Wu, Erxi, Tian, Ze, Thoma, Gebhard, Kovarik, Jiri, La Rosa, Stefano, Capella, Carlo, Rodig, Scott, Zerwes, Hans-Guenter, Sayegh, Mohamed H, Abdi, Reza

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Redirecting an anti-IL-1β antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A von Fischman, Sharon, Levin, Itay, Rondeau, Jean-Michel, Štrajbl, Marek, Lehmann, Sylvie, Huber, Thomas, Nimrod, Guy, Cebe, Régis, Omer, Dotan, Kovarik, Jiri, Bernstein, Shmuel, Sasson, Yehezkel, Demishtein, Alik, Shlamkovich, Tomer, Bluvshtein, Olga, Grossman, Noam, Barak-Fuchs, Reut, Zhenin, Michael, Fastman, Yair, Twito, Shir, Vana, Tal, Zur, Nevet, Ofran, Yanay

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From Immunosuppression to Immunomodulation: Current Principles and Future Strategies von Kovarik, Jiri

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CpG Oligodeoxynucleotides Can Circumvent the Th2 Polarization of Neonatal Responses to Vaccines But May Fail to Fully Redirect Th2 Responses Established by Neonatal Priming von Kovarik, Jiri, Bozzotti, Paola, Love-Homan, Laurie, Pihlgren, Maria, Davis, Heather L, Lambert, Paul-Henri, Krieg, Arthur M, Siegrist, Claire-Anne

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Neutralization of IL-1β and P-Selectin Inhibition Attenuate Organ Injury in Mice with Sickle Cell Disease von Gotardo, Erica M.F., Gushiken, Lucas F.S., Brito, Pamela L, Leonardo, Flavia C., Torres, Lidiane S., Agoulnik, Sergei, Kovarik, Jiri, Bruederle, Andreas, Millholland, John, Costa, Fernando Ferreira, Conran, Nicola

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Neutralization of Inflammasome-Processed Cytokines Reduces Inflammatory Mechanisms and Leukocyte Recruitment in the Vasculature of TNF-α-Stimulated Sickle Cell Disease Mice von Torres, Lidiane S., Gotardo, Erica M.F., Leonardo, Flávia Costa, Brito, Pamela L., Förster, Irmgard, Kovarik, Jiri, Costa, Fernando Ferreira, Conran, Nicola

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P-Selectin Blockage Potentiates the Inhibiting Effects of Inflammasome Cytokine Neutralization on Leukocyte Recruitment in an In Vivo Model of Acute Sickle Cell Vaso-Occlusion von Gotardo, Erica M.F., Torres, Lidiane S., Gushiken, Lucas F.S., Brito, Pamela L., Leonardo, Flavia C., Agoulnik, Sergei, Kovarik, Jiri, Bruederle, Andreas, Millholland, John, Vitaliti, Alessandra, Förster, Irmgard, Costa, Fernando Ferreira, Conran, Nicola

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Determinants of infant responses to vaccines in presence of maternal antibodies von Siegrist, Claire-Anne, Córdova, Marco, Brandt, Christian, Barrios, Christy, Berney, Monika, Tougne, Chantal, Kovarik, Jiri, Lambert, Paul-Henri

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Therapeutic activity of multiple common γ-chain cytokine inhibition in acute and chronic GVHD von Hechinger, Anne-Kathrin, Smith, BenjaminA.H., Flynn, Ryan, Hanke, Kathrin, McDonald-Hyman, Cameron, Taylor, Patricia A., Pfeifer, Dietmar, Hackanson, Björn, Leonhardt, Franziska, Prinz, Gabriele, Dierbach, Heide, Schmitt-Graeff, Annette, Kovarik, Jiri, Blazar, Bruce R., Zeiser, Robert

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The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition von Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Lafossas, Frédérique, Vedrine, Corinne, Boesch, Danielle, Kolb, Yeter, Kaiser, Daniel, Glück, Anton, Schneider, Martin A, Katopodis, Andreas, Renatus, Martin, Simic, Oliver, Schlapbach, Achim, Quancard, Jean, Régnier, Catherine H, Bold, Guido, Pissot‐Soldermann, Carole, Carballido, José M, Kovarik, Jiri, Calzascia, Thomas, Bornancin, Frédéric

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Requirement of Mucosa‐Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor–Induced Arthritis, but Not Fcγ Receptor–Mediated Platelet Elimi... von Martin, Kea, Touil, Ratiba, Cvijetic, Grozdan, Israel, Laura, Kolb, Yeter, Sarret, Sophie, Valeaux, Stéphanie, Degl'Innocenti, Elena, Le Meur, Thomas, Caesar, Nadja, Bardet, Maureen, Beerli, Christian, Zerwes, Hans‐Guenter, Kovarik, Jiri, Beltz, Karen, Schlapbach, Achim, Quancard, Jean, Régnier, Catherine H., Bigaud, Marc, Junt, Tobias, Wieczorek, Grazyna, Isnardi, Isabelle, Littlewood‐Evans, Amanda, Bornancin, Frédéric, Calzascia, Thomas

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DPP9 enzymatic activity in hematopoietic cells is dispensable for mouse hematopoiesis von Kim, Munkyung, von Muenchow, Lilly, Le Meur, Thomas, Kueng, Benjamin, Gapp, Berangere, Weber, Delphine, Dietrich, William, Kovarik, Jiri, Rolink, Antonius G., Ksiazek, Iwona

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Common Gamma Chain Cytokines Contribute To Acute GvHD Via Perforin/Granzyme B-Mediated Cytotoxicity Of CD8 T Cells von Schwarze, Vincent, Hechinger, Anne-Kathrin, Leonhardt, Franziska, Prinz, Gabriele, Schmitt-Gräff, Annette, Kovarik, Jiri, Zeiser, Robert

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Thin-film SnO2 and ZnO detectors of hydrogen peroxide vapors von Aroutiounian, Vladimir, Arakelyan, Valeri, Aleksanyan, Mikayel, Shahnazaryan, Gohar, Kacer, Petr, Picha, Pavel, Kovarik, Jiri, Pekarek, Jakub, Berndt Joost

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Visualization of secondary flow in a corner of a channel von Bém, Jindřich, Duda, Daniel, Kovařík, Jiří, Yanovych, Vitalii, Uruba, Václav

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Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2 von Arenas-Ramirez, Natalia, Zou, Chao, Popp, Simone, Zingg, Daniel, Brannetti, Barbara, Wirth, Emmanuelle, Calzascia, Thomas, Kovarik, Jiri, Sommer, Lukas, Zenke, Gerhard, Woytschak, Janine, Regnier, Catherine H, Katopodis, Andreas, Boyman, Onur

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Influence of secondary flow corner vortex to boundary layer in a channel flow von Duda, Daniel, Bém, Jindřich, Kovařík, Jiří, Yanovych, Vitalii, Uruba, Václav

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