Structural and Antiviral Studies of the Human Norovirus GII.4 Protease von Muzzarelli, Kendall M, Kuiper, Benjamin, Spellmon, Nicholas, Brunzelle, Joseph, Hackett, Justin, Amblard, Franck, Zhou, Shaoman, Liu, Peng, Kovari, Iulia A, Yang, Zhe, Schinazi, Raymond F, Kovari, Ladislau C

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The discovery of Zika virus NS2B-NS3 inhibitors with antiviral activity via an integrated virtual screening approach von Mirza, Muhammad Usman, Alanko, Ida, Vanmeert, Michiel, Muzzarelli, Kendall M., Salo-Ahen, Outi M.H., Abdullah, Iskandar, Kovari, Iulia A., Claes, Sandra, De Jonghe, Steven, Schols, Dominique, Schinazi, Raymond F., Kovari, Ladislau C., Trant, John F., Ahmad, Sarfraz, Froeyen, Matheus

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Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease von Amblard, Franck, LeCher, Julia C., De, Ramyani, Zhou, Shaoman, Liu, Peng, Goh, Shu Ling, Tao, Sijia, Patel, Dharmeshkumar, Downs-Bowen, Jessica, Zandi, Keivan, Zhang, Huanchun, Chaudhry, Gitika, McBrayer, Tamara, Muczynski, Michael, Al-Homoudi, Abdullah, Engel, Joseph, Lan, Shuiyun, Sarafianos, Stefan G., Kovari, Ladislau C., Schinazi, Raymond F.

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Novel Protease Inhibitors Containing C-5-Modified bis -Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2' Ligands That Exert Potent Antiviral Activity against Highly Mu... von Takamatsu, Yuki, Aoki, Manabu, Bulut, Haydar, Das, Debananda, Amano, Masayuki, Sheri, Venkata Reddy, Kovari, Ladislau C, Hayashi, Hironori, Delino, Nicole S, Ghosh, Arun K, Mitsuya, Hiroaki

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Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease von Kuiper, Benjamin D., Slater, Kristin, Spellmon, Nicholas, Holcomb, Joshua, Medapureddy, Prasanna, Muzzarelli, Kendall M., Yang, Zhe, Ovadia, Reuben, Amblard, Franck, Kovari, Iulia A., Schinazi, Raymond F., Kovari, Ladislau C.

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Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors von Amblard, Franck, Zhou, Shaoman, Liu, Peng, Yoon, Jack, Cox, Bryan, Muzzarelli, Kendall, Kuiper, Benjamin D., Kovari, Ladislau C., Schinazi, Raymond F.

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The higher barrier of darunavir and tipranavir resistance for HIV-1 protease von Wang, Yong, Liu, Zhigang, Brunzelle, Joseph S., Kovari, Iulia A., Dewdney, Tamaria G., Reiter, Samuel J., Kovari, Ladislau C.

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Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV... von Aoki, Manabu, Das, Debananda, Hayashi, Hironori, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Ghosh, Arun K, Mitsuya, Hiroaki

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Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants von Yedidi, Ravikiran S., Proteasa, Georghe, Martinez, Jorge L., Vickrey, John F., Martin, Philip D., Wawrzak, Zdzislaw, Liu, Zhigang, Kovari, Iulia A., Kovari, Ladislau C.

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Reduced HIV-1 integrase flexibility as a mechanism for raltegravir resistance von Dewdney, Tamaria G., Wang, Yong, Kovari, Iulia A., Reiter, Samuel J., Kovari, Ladislau C.

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Mechanism-Based Inhibitors of the Aspartyl Protease Plasmepsin II as Potential Antimalarial Agents von Gupta, Deepak, Yedidi, Ravikiran S, Varghese, Sheeba, Kovari, Ladislau C, Woster, Patrick M

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X-ray solution structure of the native neuronal porosome-synaptic vesicle complex: Implication in neurotransmitter release von Kovari, Ladislau C., Brunzelle, Joseph S., Lewis, Kenneth T., Cho, Won Jin, Lee, Jin-Sook, Taatjes, Douglas J., Jena, Bhanu P.

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“Wide-Open” 1.3 Å Structure of a Multidrug-Resistant HIV-1 Protease as a Drug Target von Martin, Philip, Vickrey, John F., Proteasa, Gheorghe, Jimenez, Yurytzy L., Wawrzak, Zdzislaw, Winters, Mark A., Merigan, Thomas C., Kovari, Ladislau C.

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Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease von Dewdney, Tamaria G., Wang, Yong, Liu, Zhigang, Sharma, Shiv K., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Woster, Patrick M., Kovari, Ladislau C.

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Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes von Liu, Zhigang, Wang, Yong, Yedidi, Ravikiran S., Dewdney, Tamaria G., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.

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Crystal structure of the extracellular domain of human myelin protein zero von Liu, Zhigang, Wang, Yong, Yedidi, Ravikiran S., Brunzelle, Joseph S., Kovari, Iulia A., Sohi, Jasloveleen, Kamholz, John, Kovari, Ladislau C.

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Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: Mechanism of drug recognition and resistance von Liu, Zhigang, Yedidi, Ravikiran S., Wang, Yong, Dewdney, Tamaria G., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.

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Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex von Liu, Zhigang, Yedidi, Ravikiran S., Wang, Yong, Dewdney, Tamaria G., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.

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Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds von Yedidi, Ravikiran S., Liu, Zhigang, Wang, Yong, Brunzelle, Joseph S., Kovari, Iulia A., Woster, Patrick M., Kovari, Ladislau C., Gupta, Deepak

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P1 and P1′ para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: Structure-based virtual screening of extended lopinavir analogs again... von Yedidi, Ravikiran S., Liu, Zhigang, Kovari, Iulia A., Woster, Patrick M., Kovari, Ladislau C.

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