Clinical and Biological Subtypes of B-cell Lymphoma Revealed by Microenvironmental Signatures von Kotlov, Nikita, Bagaev, Alexander, Revuelta, Maria, Phillip, Jude M., Cacciapuoti, Maria Teresa, Antysheva, Zoya, Svekolkin, Viktor, Tikhonova, Ekaterina, Miheecheva, Natalia, Kuzkina, Natalia, Nos, Grigorii, Tabbo, Fabrizio, Frenkel, Felix, Ghione, Paola, Tsiper, Maria, Almog, Nava, Fowler, Nathan, Melnick, Ari M., Leonard, John P., Inghirami, Giorgio, Cerchietti, Leandro

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Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma von Razzaghi, Raud, Agarwal, Shreya, Kotlov, Nikita, Plotnikova, Olga, Nomie, Krystle, Huang, Da Wei, Wright, George W., Smith, Grace A., Li, Moyi, Takata, Katsuyoshi, Yamadi, Maryam, Yao, Chen, O'Shea, John J., Phelan, James D., Pittaluga, Stefania, Scott, David W., Muppidi, Jagan R.

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Immune-depleted tumor microenvironment is associated with poor outcomes and BTK inhibitor resistance in mantle cell lymphoma von Jain, Preetesh, Nomie, Krystle, Kotlov, Nikita, Segodin, VitaIy, Hill, Holly, Ok, Chi Young, Fetooh, Ahmed, Kanagal-Shamanna, Rashmi, Vega, Francisco, Bagaev, Alexander, Fowler, Nathan, Flowers, Christopher R., Wang, Michael

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Microenvironmental Signatures Reveal Biological Subtypes of Diffuse Large B-Cell Lymphoma (DLBCL) Distinct from Tumor Cell Molecular Profiling von Cerchietti, Leandro, Inghirami, Giorgio, Kotlov, Nikita, Svekolkin, Viktor, Bagaev, Alexander, Frenkel, Felix, Revuelta, Maria Victoria, Phillip, Jude M, Cacciapuoti, Maria Teresa, Rutherford, Sarah C., Martin, Peter, Leonard, John P.

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Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma von Broner, Esther C., Trujillo, Jonathan A., Korzinkin, Michael, Subbannayya, Tejaswini, Agrawal, Nishant, Ozerov, Ivan, Zhavoronkov, Alex, Rooper, Lisa, Kotlov, Nikita, Shen, Le, Pearson, Alexander T., Rosenberg, Ari J., Savage, Peter A., Mishra, Vasudha, Chatterjee, Aditi, Sidransky, David, Izumchenko, Evgeny

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Deciphering the origin and therapeutic targets of cancer of unknown primary: a case report that illustrates the power of integrative whole-exome and transcriptome sequencing analys... von Al Assaad, Majd, Shin, Nara, Sigouros, Michael, Manohar, Jyothi, Antysheva, Zoia, Kotlov, Nikita, Kiriy, Daria, Nikitina, Anastasiia, Kleimenov, Mikhail, Tsareva, Anastasiya, Makarova, Anastasiya, Fomchenkova, Victoria, Dubinina, Julia, Boyko, Alexandra, Almog, Nava, Wilkes, David, Escalon, Joanna G, Saxena, Ashish, Elemento, Olivier, Sternberg, Cora N, Nanus, David M, Mosquera, Juan Miguel

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532 A cross-cohort examination of factors impacting immunotherapy survival in non-small cell lung cancer (NSCLC) von Danilov, Konstantin, Bansal, Dhruv, Valiev, Ivan, Kushnarev, Vladimir, Ward, Chris, Al-Obaidi, Ammar, Pluard, Timothy, Tarasov, Artem, Makarova, Anastasiia, Butusova, Anna, Love, Anna, Nomie, Krystle, Kotlov, Nikita, Subramanian, Janakiraman, Bagaev, Alexander

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555 Challenges in predicting ICI response in HPV+ HNSCC: insights into the tumor microenvironment von Nikitina, Anastasiia, Sobol, Anastasia, Alekseeva, Evgeniia, Tyshevich, Andrey, Love, Anna, Luginbuhl, Adam J, Linnenbach, Alban J, Curry, Joseph M, Kushnarev, Vladimir, Davitt, Christopher JH, Kotlov, Nikita, Bagaev, Alexander, Fowler, Nathan

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Conserved pan-cancer microenvironment subtypes predict response to immunotherapy von Bagaev, Alexander, Kotlov, Nikita, Nomie, Krystle, Svekolkin, Viktor, Gafurov, Azamat, Isaeva, Olga, Osokin, Nikita, Kozlov, Ivan, Frenkel, Felix, Gancharova, Olga, Almog, Nava, Tsiper, Maria, Ataullakhanov, Ravshan, Fowler, Nathan

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Procrustes is a machine-learning approach that removes cross-platform batch effects from clinical RNA sequencing data von Kotlov, Nikita, Shaposhnikov, Kirill, Tazearslan, Cagdas, Chasse, Madison, Baisangurov, Artur, Podsvirova, Svetlana, Fernandez, Dawn, Abdou, Mary, Kaneunyenye, Leznath, Morgan, Kelley, Cheremushkin, Ilya, Zemskiy, Pavel, Chelushkin, Maxim, Sorokina, Maria, Belova, Ekaterina, Khorkova, Svetlana, Lozinsky, Yaroslav, Nuzhdina, Katerina, Vasileva, Elena, Kravchenko, Dmitry, Suryamohan, Kushal, Nomie, Krystle, Curran, John, Fowler, Nathan, Bagaev, Alexander

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P1205: A LIVING PATIENT‐DERIVED BIOREPOSITORY FOSTERING MICROENVIRONMENT DISSECTION IN T‐CELL LYMPHOMA von Fiore, Danilo, Vincenzo Cappelli, Luca, Zhaoqi, Liu, Kotlov, Nikita, Sorokina, Maria, Phillip, Jude, Zumbo, Paul, Yoffe, Liron, Xueshuai, Han, Pignataro, Claudia, Ghione, Paola, Fragliasso, Valentina, Condorelli, Gerolama, Foà, Robin, Brody, Joshua, Betel, Doron, Chan, Wing C, Tam, Wayne, Nikitina, Anastasie, Bagaev, Aleksander, Fowler, Nathan, Weinstock, David, Cerchietti, Leandro, Rabadan, Raul, Horwitz, Steve, Inghirami, Giorgio

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S235: GENERATION AND APPLICATION OF A LIVING T‐CELL LYMPHOMA PATIENT‐DERIVED TUMOR XENOGRAFT BIOREPOSITORY von Cappelli, Luca Vincenzo, Fiore, Danilo, Zhaoqi, Liu, Kotlov, Nikita, Phillip, Jude, Zumbo, Paul, Yoffe, Liron, Pignataro, Claudia, Ghione, Paola, Xueshuai, Han, Fragliasso, Valentina, Condorelli, Gerolama, Foà, Robin, Brody, Joshua, Betel, Doron, Chan, John, Tam, Wayne, Weinstock, David, Cerchietti, Leandro, Rabadan, Raul, Horwitz, Steven, Inghirami, Giorgio

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B-Cell Infiltrate in the Tumor Microenvironment Is Associated With Improved Survival in Resected Lung Adenocarcinoma von Dagogo-Jack, Ibiayi, Valiev, Ivan, Kotlov, Nikita, Belozerova, Anna, Lopareva, Aleksandra, Butusova, Anna, Samarina, Naira, Boyko, Alexandra, Xiang, Zhongmin, Johnson, Monique, Degryse, Sandrine, Keane, Florence K., Sequist, Lecia V., Lanuti, Michael, Fowler, Nathan, Mino-Kenudson, Mari, Bagaev, Alexander

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A new species of Cyanea jellyfish sympatric to C. capillata in the White Sea von Kolbasova, Glafira D., Zalevsky, Arthur O., Gafurov, Azamat R., Gusev, Philipp O., Ezhova, Margarita A., Zheludkevich, Anna A., Konovalova, Olga P., Kosobokova, Ksenia N., Kotlov, Nikita U., Lanina, Natalia O., Lapashina, Anna S., Medvedev, Dmitry O., Nosikova, Katerina S., Nuzhdina, Ekaterina O., Bazykin, Georgii A., Neretina, Tatyana V.

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A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications von Wright, George W., Huang, Da Wei, Phelan, James D., Coulibaly, Zana A., Roulland, Sandrine, Young, Ryan M., Wang, James Q., Schmitz, Roland, Morin, Ryan D., Tang, Jeffrey, Jiang, Aixiang, Bagaev, Aleksander, Plotnikova, Olga, Kotlov, Nikita, Johnson, Calvin A., Wilson, Wyndham H., Scott, David W., Staudt, Louis M.

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Multicenter phase 2 study of oral azacitidine (CC-486) plus CHOP as initial treatment for PTCL von Ruan, Jia, Moskowitz, Alison, Mehta-Shah, Neha, Sokol, Lubomir, Chen, Zhengming, Kotlov, Nikita, Nos, Grigorii, Sorokina, Maria, Maksimov, Vladislav, Sboner, Andrea, Sigouros, Michael, van Besien, Koen, Horwitz, Steven, Rutherford, Sarah C., Mulvey, Erin, Revuelta, Maria V., Xiang, Jenny, Alonso, Alicia, Melnick, Ari, Elemento, Olivier, Inghirami, Giorgio, Leonard, John P., Cerchietti, Leandro, Martin, Peter

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Abstract 4418: Integrated whole exome and transcriptome analyses of the tumor and microenvironment provide new opportunities for rational design of cancer therapy von Bagaev, Alexander, Kotlov, Nikita, Frenkel, Felix, Svekolkin, Viktor, Almog, Nava, Ataullakhanov, Ravshan, Fowler, Nathan

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Aggregated analysis of 1,000 patients with cancer to assess the benefits of integrated whole exome and whole transcriptome sequencing von Chernyshov, Konstantin, Love, Anna, Senichkin, Viacheslav, Sagaradze, Georgy, Rumyantsev, Konstantin, Kushnarev, Vladimir, Postovalova, Ekaterina, Kotlov, Nikita, Ogloblina, Anna, Bagaev, Alexander, Fowler, Nathan

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Tumor immunity portrait: An AI-driven molecular predictor combining tumor microenvironment and tumor mutational burden for immune checkpoint inhibitor response prediction von Shilo, Polina, Tarasov, Artem, Filatova, Anna, Danilov, Konstantin, Valiev, Ivan, Kotlov, Nikita, Brown, Jessica H., Ogloblina, Anna, Bagaev, Alexander, Fowler, Nathan

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Genomic characterization of the GATA3 mutational landscape in breast cancer von Mouabbi, Jason A, Meric-Bernstam, Funda, Turova, Polina, Chernyshov, Konstantin, Kushnarev, Vladimir, Kotlov, Nikita, Brown, Jessica H., Clayton, Patrick, Nomie, Krystle, Fowler, Nathan, Tripathy, Debu, Damodaran, Senthil

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