Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing von Yin, Hao, Song, Chun-Qing, Suresh, Sneha, Wu, Qiongqiong, Walsh, Stephen, Rhym, Luke Hyunsik, Mintzer, Esther, Bolukbasi, Mehmet Fatih, Zhu, Lihua Julie, Kauffman, Kevin, Mou, Haiwei, Oberholzer, Alicia, Ding, Junmei, Kwan, Suet-Yan, Bogorad, Roman L, Zatsepin, Timofei, Koteliansky, Victor, Wolfe, Scot A, Xue, Wen, Langer, Robert, Anderson, Daniel G

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Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration von Raven, Alexander, Lu, Wei-Yu, Man, Tak Yung, Ferreira-Gonzalez, Sofia, O’Duibhir, Eoghan, Dwyer, Benjamin J., Thomson, John P., Meehan, Richard R., Bogorad, Roman, Koteliansky, Victor, Kotelevtsev, Yuri, ffrench-Constant, Charles, Boulter, Luke, Forbes, Stuart J.

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Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo von Yin, Hao, Song, Chun-Qing, Dorkin, Joseph R, Zhu, Lihua J, Li, Yingxiang, Wu, Qiongqiong, Park, Angela, Yang, Junghoon, Suresh, Sneha, Bizhanova, Aizhan, Gupta, Ankit, Bolukbasi, Mehmet F, Walsh, Stephen, Bogorad, Roman L, Gao, Guangping, Weng, Zhiping, Dong, Yizhou, Koteliansky, Victor, Wolfe, Scot A, Langer, Robert, Xue, Wen, Anderson, Daniel G

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Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape von Gilleron, Jerome, Querbes, William, Zeigerer, Anja, Borodovsky, Anna, Marsico, Giovanni, Schubert, Undine, Manygoats, Kevin, Seifert, Sarah, Andree, Cordula, Stöter, Martin, Epstein-Barash, Hila, Zhang, Ligang, Koteliansky, Victor, Fitzgerald, Kevin, Fava, Eugenio, Bickle, Marc, Kalaidzidis, Yannis, Akinc, Akin, Maier, Martin, Zerial, Marino

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RNAi therapeutics: a potential new class of pharmaceutical drugs von Sah, Dinah W Y, Bumcrot, David, Manoharan, Muthiah, Koteliansky, Victor

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MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter von Csordás, György, Golenár, Tünde, Seifert, Erin L., Kamer, Kimberli J., Sancak, Yasemin, Perocchi, Fabiana, Moffat, Cynthia, Weaver, David, Perez, Sergio de la Fuente, Bogorad, Roman, Koteliansky, Victor, Adijanto, Jeffrey, Mootha, Vamsi K., Hajnóczky, György

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MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling von Plovanich, Molly, Bogorad, Roman L, Sancak, Yasemin, Kamer, Kimberli J, Strittmatter, Laura, Li, Andrew A, Girgis, Hany S, Kuchimanchi, Satya, De Groot, Jack, Speciner, Lauren, Taneja, Nathan, Oshea, Jonathan, Koteliansky, Victor, Mootha, Vamsi K

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Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates von Dong, Yizhou, Love, Kevin T., Dorkin, J. Robert, Sirirungruang, Sasilada, Zhang, Yunlong, Chen, Delai, Bogorad, Roman L., Yin, Hao, Chen, Yi, Vegas, Arturo J., Alabi, Christopher A., Sahay, Gaurav, Olejnik, Karsten T., Wang, Weiheng, Schroeder, Avi, Lytton-Jean, Abigail K. R., Siegwart, Daniel J., Akinc, Akin, Barnes, Carmen, Barros, Scott A., Carioto, Mary, Fitzgerald, Kevin, Hettinger, Julia, Kumar, Varun, Novobrantseva, Tatiana I., Qin, June, Querbes, William, Koteliansky, Victor, Langer, Robert, Anderson, Daniel G.

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The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals von Moon, Young-Ah, Liang, Guosheng, Xie, Xuefen, Frank-Kamenetsky, Maria, Fitzgerald, Kevin, Koteliansky, Victor, Brown, Michael S., Goldstein, Joseph L., Horton, Jay D.

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Therapeutic siRNA silencing in inflammatory monocytes in mice von Weissleder, Ralph, Nahrendorf, Matthias, Leuschner, Florian, Dutta, Partha, Gorbatov, Rostic, Novobrantseva, Tatiana I, Donahoe, Jessica S, Courties, Gabriel, Lee, Kang Mi, Kim, James I, Markmann, James F, Marinelli, Brett, Panizzi, Peter, Lee, Won Woo, Iwamoto, Yoshiko, Milstein, Stuart, Epstein-Barash, Hila, Cantley, William, Wong, Jamie, Cortez-Retamozo, Virna, Newton, Andita, Love, Kevin, Libby, Peter, Pittet, Mikael J, Swirski, Filip K, Koteliansky, Victor, Langer, Robert, Anderson, Daniel G

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Origins of tumor-associated macrophages and neutrophils von Cortez-Retamozo, Virna, Etzrodt, Martin, Newton, Andita, Rauch, Philipp J, Chudnovskiy, Aleksey, Berger, Cedric, Ryan, Russell J. H, Iwamoto, Yoshiko, Marinelli, Brett, Gorbatov, Rostic, Forghani, Reza, Novobrantseva, Tatiana I, Koteliansky, Victor, Figueiredo, Jose-Luiz, Chen, John W, Anderson, Daniel G, Nahrendorf, Matthias, Swirski, Filip K, Weissleder, Ralph, Pittet, Mikael J

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Rab5 is necessary for the biogenesis of the endolysosomal system in vivo von Zeigerer, Anja, Gilleron, Jerome, Bogorad, Roman L., Marsico, Giovanni, Nonaka, Hidenori, Seifert, Sarah, Epstein-Barash, Hila, Kuchimanchi, Satya, Peng, Chang Geng, Ruda, Vera M., Conte-Zerial, Perla Del, Hengstler, Jan G., Kalaidzidis, Yannis, Koteliansky, Victor, Zerial, Marino

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Lipid-like materials for low-dose, in vivo gene silencing von Love, Kevin T, Mahon, Kerry P, Levins, Christopher G, Whitehead, Kathryn A, Querbes, William, Dorkin, J. Robert, Qin, June, Cantley, William, Qin, Liu Liang, Racie, Timothy, Frank-Kamenetsky, Maria, Yip, Ka Ning, Alvarez, Rene, Sah, Dinah W.Y, de Fougerolles, Antonin, Fitzgerald, Kevin, Koteliansky, Victor, Akinc, Akin, Langer, Robert, Anderson, Daniel G

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Liquid-crystal organization of liver tissue von Morales-Navarrete, Hernán, Nonaka, Hidenori, Scholich, André, Segovia-Miranda, Fabián, de Back, Walter, Meyer, Kirstin, Bogorad, Roman L, Koteliansky, Victor, Brusch, Lutz, Kalaidzidis, Yannis, Jülicher, Frank, Friedrich, Benjamin M, Zerial, Marino

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Mechanisms and optimization of in vivo delivery of lipophilic siRNAs von Stoffel, Markus, Wolfrum, Christian, Shi, Shuanping, Jayaprakash, K Narayanannair, Jayaraman, Muthusamy, Wang, Gang, Pandey, Rajendra K, Rajeev, Kallanthottathil G, Nakayama, Tomoko, Charrise, Klaus, Ndungo, Esther M, Zimmermann, Tracy, Koteliansky, Victor, Manoharan, Muthiah

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Control of hepatocyte proliferation and survival by Fgf receptors is essential for liver regeneration in mice von Padrissa-Altés, Susagna, Bachofner, Marc, Bogorad, Roman L, Pohlmeier, Lea, Rossolini, Thomas, Böhm, Friederike, Liebisch, Gerhard, Hellerbrand, Claus, Koteliansky, Victor, Speicher, Tobias, Werner, Sabine

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Synthesis and biological evaluation of Doxorubicin-containing conjugate targeting PSMA von Ivanenkov, Yan A., Machulkin, Alexey E., Garanina, Anastasia S., Skvortsov, Dmitry A., Uspenskaya, Anastasia A., Deyneka, Ekaterina V., Trofimenko, Alexander V., Beloglazkina, Elena K., Zyk, Nikolay V., Koteliansky, Victor E, Bezrukov, Dmitry S., Aladinskaya, Anastasia V., Vorobyeva, Nataliya S., Puchinina, Maria M., Riabykh, Grigory K., Sofronova, Alina A., Malyshev, Alexander S., Majouga, Alexander G.

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Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads von Belicova, Lenka, Repnik, Urska, Delpierre, Julien, Gralinska, Elzbieta, Seifert, Sarah, Valenzuela, José Ignacio, Morales-Navarrete, Hernán Andrés, Franke, Christian, Räägel, Helin, Shcherbinina, Evgeniya, Prikazchikova, Tatiana, Koteliansky, Victor, Vingron, Martin, Kalaidzidis, Yannis L., Zatsepin, Timofei, Zerial, Marino

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Identification of a long non-coding RNA regulator of liver carcinoma cell survival von Rybakova, Yulia, Gonzalez, John T., Bogorad, Roman, Chauhan, Vikash P., Dong, Yize L., Whittaker, Charles A., Zatsepin, Timofei, Koteliansky, Victor, Anderson, Daniel G.

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Synthesis and biological evaluation of PSMA-targeting paclitaxel conjugates von Machulkin, Alexey E., Skvortsov, Dmitry A., Ivanenkov, Yan A., Ber, Anton P., Kavalchuk, Mikhail V., Aladinskaya, Anastasia V., Uspenskaya, Anastasia A., Shafikov, Radik R., Plotnikova, Ekaterina A., Yakubovskaya, Raisa I., Nimenko, Ekaterina A., Zyk, Nikolay U., Beloglazkina, Elena K., Zyk, Nikolay V., Koteliansky, Victor E, Majouga, Alexander G.

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