PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1 von Ebi, Hiromichi, Costa, Carlotta, Faber, Anthony C., Nishtala, Madhuri, Kotani, Hiroshi, Juric, Dejan, Pelle, Patricia Della, Song, Youngchul, Yano, Seiji, Mino-Kenudson, Mari, Benes, Cyril H., Engelman, Jeffrey A.

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Resistance mediated by alternative receptor tyrosine kinases in FGFR1-amplified lung cancer von Adachi, Yuta, Watanabe, Kazuyoshi, Kita, Kenji, Kitai, Hidenori, Kotani, Hiroshi, Sato, Yuki, Inase, Naohiko, Yano, Seiji, Ebi, Hiromichi

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Dual inhibition of SUMOylation and MEK conquers MYC-expressing KRAS-mutant cancers by accumulating DNA damage von Kotani, Hiroshi, Oshima, Hiroko, Boucher, Justin C, Yamano, Tomoyoshi, Sakaguchi, Hiroyuki, Sato, Shigeki, Fukuda, Koji, Nishiyama, Akihiro, Yamashita, Kaname, Ohtsubo, Koushiro, Takeuchi, Shinji, Nishiuchi, Takumi, Oshima, Masanobu, Davila, Marco L, Yano, Seiji

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Effectiveness of Additional Immunosuppressive Drugs for Corticosteroid-refractory Immune Checkpoint Inhibitor-induced Myocarditis: Two Case Reports von Sakaguchi, Hiroyuki, Nanjo, Shigeki, Sato, Shigeki, Kotani, Hiroshi, Nishiyama, Akihiro, Yamashita, Kaname, Ohtsubo, Koushiro, Suzuki, Chiaki, Shimojima, Masaya, Yano, Seiji, Takeuchi, Shinji

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Case report: Navigating treatment pathways for cardiac intimal sarcoma with PDGFRβ N666K mutation von Nishiyama, Akihiro, Sato, Shigeki, Sakaguchi, Hiroyuki, Kotani, Hiroshi, Yamashita, Kaname, Ohtsubo, Koushiro, Mizuguchi, Keishi, Ikeda, Hiroko, Iino, Kenji, Takemura, Hirofumi, Takeuchi, Shinji

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Comprehensive antitumor immune response boosted by dual inhibition of SUMOylation and MEK in MYC-expressing KRAS-mutant cancers von Kotani, Hiroshi, Yamano, Tomoyoshi, Boucher, Justin C, Sato, Shigeki, Sakaguchi, Hiroyuki, Fukuda, Koji, Nishiyama, Akihiro, Yamashita, Kaname, Ohtsubo, Koushiro, Takeuchi, Shinji, Nishiuchi, Takumi, Oshima, Hiroko, Oshima, Masanobu, Davila, Marco L, Yano, Seiji

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Pulmonary carcinosarcoma showing an obvious response to pazopanib: a case report von Tanimoto, Azusa, Takeuchi, Shinji, Kotani, Hiroshi, Yamashita, Kaname, Yamada, Tadaaki, Ohtsubo, Koushiro, Ebi, Hiromichi, Ikeda, Hiroko, Yano, Seiji

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Hidden disseminated extracutaneous AIDS-related Kaposi sarcoma von Kawakami, Naoki, Namkoong, Ho, Shimoda, Masayuki, Kotani, Hiroshi, Fujiwara, Hiroshi, Hasegawa, Naoki

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C-terminal splice variants of P/Q-type Ca2+ channel CaV2.1 α1 subunits are differentially regulated by Rab3-interacting molecule proteins von Hirano, Mitsuru, Takada, Yoshinori, Wong, Chee Fah, Yamaguchi, Kazuma, Kotani, Hiroshi, Kurokawa, Tatsuki, Mori, Masayuki X., Snutch, Terrance P., Ronjat, Michel, De Waard, Michel, Mori, Yasuo

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IL-6 and G-CSF production resulting from lung cancer in an HIV patient von Kawakami, Naoki, Namkoong, Ho, Masaki, Katsunori, Kurebayashi, Yutaka, Shimoda, Masayuki, Kotani, Hiroshi, Fujiwara, Hiroshi, Hasegawa, Naoki

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105 4–1BB and optimized CD28 co-stimulation enhances function of human mono- and bi-specific third-generation CAR T cells von Roselli, Emiliano, Boucher, Justin, Li, Gongbo, Kotani, Hiroshi, Spitler, Kristen, Reid, Kayla, Bulliard, Yannick, Tu, Nhan, Lee, Sae Bom, Yu, Bin, Locke, Frederick, Davila, Marco

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Tumor Microenvironment Composition and Severe Cytokine Release Syndrome (CRS) Influence Toxicity in Patients with Large B-Cell Lymphoma Treated with Axicabtagene Ciloleucel von Faramand, Rawan, Jain, Michael, Staedtke, Verena, Kotani, Hiroshi, Bai, Renyuan, Reid, Kayla, Lee, Sae Bom, Spitler, Kristen, Wang, Xuefeng, Cao, Biwei, Pinilla, Javier, Lazaryan, Aleksander, Khimani, Farhad, Shah, Bijal, Chavez, Julio C., Nishihori, Taiga, Mishra, Asmita, Mullinax, John, Gonzalez, Ricardo, Hussaini, Mohammad, Dam, Marian, Brandjes, Brigett D., Bachmeier, Christina A., Anasetti, Claudio, Locke, Frederick L., Davila, Marco L.

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A Novel IL2Rα-/- Model for CAR-T Toxicity in Acute Lymphoblastic Leukemia Recapitulates Cytokine Release Syndrome and Neutropenia von Goala, Payal, Kotani, Hiroshi, Yongliang, Zhang, Reid, Kayla M., Boucher, Justin C., Savid-Frontera, Constanza, Lee, Sae Bom, Beatty, Nolan, Jain, Michael D., Davila, Marco L.

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Abstract 749: Both amplification and protein expression are required to predict FGFR tyrosine kinase inhibitor sensitivity in lung cancer von Ebi, Hiromichi, Kotani, Hiroshi, Yano, Seiji

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Distinct dependencies on receptor tyrosine kinases in the regulation of MAPK signaling between BRAF V600E and non-V600E mutant lung cancers von Kotani, Hiroshi, Adachi, Yuta, Kitai, Hidenori, Tomida, Shuta, Bando, Hideaki, Faber, Anthony C., Yoshino, Takayuki, Voon, Dominic C., Yano, Seiji, Ebi, Hiromichi

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Pembrolizumab efficacy in a tumor mutation burden-high glioblastoma patient: A case study and implications for precision oncology von Nishiyama, Akihiro, Sato, Shigeki, Sakaguchi, Hiroyuki, Kotani, Hiroshi, Yamashita, Kaname, Ohtsubo, Koushiro, Sekiya, Tomoko, Watanabe, Atsushi, Tajima, Atsushi, Shimaguchi, Chie, Mizuguchi, Keishi, Ikeda, Hiroko, Kinoshita, Masashi, Nakada, Mitsutoshi, Takeuchi, Shinji

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Co-active receptor tyrosine kinases mitigate the effect of FGFR inhibitors in FGFR1-amplified lung cancers with low FGFR1 protein expression von Kotani, H, Ebi, H, Kitai, H, Nanjo, S, Kita, K, Huynh, T G, Ooi, A, Faber, A C, Mino-Kenudson, M, Yano, S

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Selective TRAF over-expression enhances CD19-targeted 41BB CAR T function by increasing NF-κB von Li, Gongbo, Boucher, Justin C., Kotani, Hiroshi, Zhang, Yongliang, Shrestha, Bishwas, Yu, Bin, Davila, Marco L.

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C-terminal splice variants of P/Q-type Ca(2+) channel CaV2.1 α1 subunits are differentially regulated by Rab3-interacting molecule proteins von Hirano, Mitsuru, Takada, Yoshinori, Wong, Chee Fah, Yamaguchi, Kazuma, Kotani, Hiroshi, Kurokawa, Tatsuki, Mori, Masayuki X., Snutch, Terrance P., Ronjat, Michel, de Waard, Michel, Mori, Yasuo

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MO2-10-2Aged donor derived CAR-T exhibits enhanced effector functions but shorter persistence and less memory-like phenotypes von Kotani, Hiroshi, Li, Gongbo, Yao, Jiqiang, Mesa, Tania E, Chen, Jon, Yu, Bin, Boucher, Justin C, Yoder, Sean J, Zhou, Jing, Davila, Marco L

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