Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study von Noth, Imre, Prof, Zhang, Yingze, PhD, Ma, Shwu-Fan, PhD, Flores, Carlos, PhD, Barber, Mathew, PhD, Huang, Yong, MS, Broderick, Steven M, BS, Wade, Michael S, MS, Hysi, Pirro, PhD, Scuirba, Joseph, BS, Richards, Thomas J, PhD, Juan-Guardela, Brenda M, MD, Vij, Rekha, MD, Han, MeiLan K, MD, Martinez, Fernando J, Prof, Kossen, Karl, PhD, Seiwert, Scott D, PhD, Christie, Jason D, MD, Nicolae, Dan, Prof, Kaminski, Naftali, Prof, Garcia, Joe GN, Prof

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Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227) von Seiwert, Scott D, Andrews, Steven W, Jiang, Yutong, Serebryany, Vladimir, Tan, Hua, Kossen, Karl, Rajagopalan, P T Ravi, Misialek, Shawn, Stevens, Sarah K, Stoycheva, Antitsa, Hong, Jin, Lim, Sharlene R, Qin, Xiaoli, Rieger, Robert, Condroski, Kevin R, Zhang, Hailong, Do, Mary Geck, Lemieux, Christine, Hingorani, Gary P, Hartley, Dylan P, Josey, John A, Pan, Lin, Beigelman, Leonid, Blatt, Lawrence M

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Virologic Escape during Danoprevir (ITMN-191/RG7227) Monotherapy Is Hepatitis C Virus Subtype Dependent and Associated with R155K Substitution von LIM, Sharlene R, XIAOLI QIN, NAJERA, Isabel, SMITH, Patrick, ZEUZEM, Stefan, KOSSEN, Karl, SARRAZIN, Christophe, SEIWERT, Scott D, SUSSER, Simone, NICHOLAS, John B, LANGE, Christian, HERRMANN, Eva, JIN HONG, ARFSTEN, Ann, HOOI, Lisa, BRADFORD, Williamson

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Inhibition and Binding Kinetics of the Hepatitis C Virus NS3 Protease Inhibitor ITMN-191 Reveals Tight Binding and Slow Dissociative Behavior von Rajagopalan, Ravi, Misialek, Shawn, Stevens, Sarah K, Myszka, David G, Brandhuber, Barbara J, Ballard, Joshua A, Andrews, Steven W, Seiwert, Scott D, Kossen, Karl

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Danoprevir Monotherapy Decreases Inflammatory Markers in Patients with Chronic Hepatitis C Virus Infection von SCHAEFER, Caralee J, KOSSEN, Karl, LIM, Sharlene R, LIN, Jiing-Huey, LIN PAN, BRADFORD, Williamson, SMITH, Patrick F, SEIWERT, Scott D

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Effect of chemically modified IL-13 short interfering RNA on development of airway hyperresponsiveness in mice von Lively, Tricia N., PhD, Kossen, Karl, PhD, Balhorn, Annette, BS, Koya, Toshiyuki, MD, PhD, Zinnen, Shawn, PhD, Takeda, Katsuyuki, MD, PhD, Lucas, Joseph J., PhD, Polisky, Barry, PhD, Richards, Ivan M., PhD, Gelfand, Erwin W., MD

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HCV NS5B polymerase inhibitors 3: Synthesis and in vitro activity of 3-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy-2H-quinolizin-2-one derivatives von Wang, Guangyi, Zhang, Laiguo, Wu, Xiaomin, Das, Debasis, Ruhrmund, Donald, Hooi, Lisa, Misialek, Shawn, Ravi Rajagopalan, P.T., Buckman, Brad O., Kossen, Karl, Seiwert, Scott D., Beigelman, Leonid

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HCV NS5B polymerase inhibitors 1: Synthesis and in vitro activity of 2-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives von Wang, Guangyi, He, Yanzhen, Sun, Jun, Das, Debasis, Hu, Mougang, Huang, Jianhua, Ruhrmund, Donald, Hooi, Lisa, Misialek, Shawn, Ravi Rajagopalan, P.T., Stoycheva, Antitsa, Buckman, Brad O., Kossen, Karl, Seiwert, Scott D., Beigelman, Leonid

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Association Between the MUC5B Promoter Polymorphism and Survival in Patients With Idiopathic Pulmonary Fibrosis von Peljto, Anna L, Zhang, Yingze, Fingerlin, Tasha E, Ma, Shwu-Fan, Garcia, Joe G. N, Richards, Thomas J, Silveira, Lori J, Lindell, Kathleen O, Steele, Mark P, Loyd, James E, Gibson, Kevin F, Seibold, Max A, Brown, Kevin K, Talbert, Janet L, Markin, Cheryl, Kossen, Karl, Seiwert, Scott D, Murphy, Elissa, Noth, Imre, Schwarz, Marvin I, Kaminski, Naftali, Schwartz, David A

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Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis von Fingerlin, Tasha E, Murphy, Elissa, Zhang, Weiming, Peljto, Anna L, Brown, Kevin K, Steele, Mark P, Loyd, James E, Cosgrove, Gregory P, Lynch, David, Groshong, Steve, Collard, Harold R, Wolters, Paul J, Bradford, Williamson Z, Kossen, Karl, Seiwert, Scott D, du Bois, Roland M, Garcia, Christine Kim, Devine, Megan S, Gudmundsson, Gunnar, Isaksson, Helgi J, Kaminski, Naftali, Zhang, Yingze, Gibson, Kevin F, Lancaster, Lisa H, Cogan, Joy D, Mason, Wendi R, Maher, Toby M, Molyneaux, Philip L, Wells, Athol U, Moffatt, Miriam F, Selman, Moises, Pardo, Annie, Kim, Dong Soon, Crapo, James D, Make, Barry J, Regan, Elizabeth A, Walek, Dinesha S, Daniel, Jerry J, Kamatani, Yoichiro, Zelenika, Diana, Smith, Keith, McKean, David, Pedersen, Brent S, Talbert, Janet, Kidd, Raven N, Markin, Cheryl R, Beckman, Kenneth B, Lathrop, Mark, Schwarz, Marvin I, Schwartz, David A

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Zeptomole detection of a viral nucleic acid using a target-activated ribozyme von Vaish, Narendra K, Jadhav, Vasant R, Kossen, Karl, Pasko, Christopher, Andrews, Lori E, McSwiggen, James A, Polisky, Barry, Seiwert, Scott D

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IDL-2965: a selective, highly potent, clinical-stage integrin antagonist for treatment of non-alcoholic steatohepatitis von Kossen, Karl, Schaefer, Caralee, Lim, Sharlene, Michener, Marshall, Griggs, Dave, Ruminski, Peter, Radhakrishnan, Ramachandran, Rubino, Christopher, Marmon, Tonya, Gershman, Ari, Hanning, Roxann, Jones, Renee, Kamau-Kelley, Watiri, Seiwert, Scott

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FRI103 - IDL-2965: a selective, highly potent, clinical-stage integrin antagonist for treatment of non-alcoholic steatohepatitis von Kossen, Karl, Schaefer, Caralee, Lim, Sharlene, Michener, Marshall, Griggs, Dave, Ruminski, Peter, Radhakrishnan, Ramachandran, Rubino, Christopher, Marmon, Tonya, Gershman, Ari, Hanning, Roxann, Jones, Renee, Kamau-Kelley, Watiri, Seiwert, Scott

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The Carboxy-terminal Domain of the DEx Protein YxiN is Sufficient to Confer Specificity for 23S rRNA von Kossen, Karl, Karginov, Fedor V., Uhlenbeck, Olke C.

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Preclinical Characterization and Human Microdose Pharmacokinetics of ITMN-8187, a Nonmacrocyclic Inhibitor of the Hepatitis C Virus NS3 Protease von Rajagopalan, Ravi, Pan, Lin, Schaefer, Caralee, Nicholas, John, Lim, Sharlene, Misialek, Shawn, Stevens, Sarah, Hooi, Lisa, Aleskovski, Natalia, Ruhrmund, Donald, Kossen, Karl, Huang, Lea, Yap, Sophia, Beigelman, Leonid, Serebryany, Vladimir, Liu, Jyanwei, Sastry, Srikonda, Seiwert, Scott, Buckman, Brad

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The Escherichia coli DEAD protein DbpA recognizes a small RNA hairpin in 23S rRNA von TSU, CHRISTOPHER A., KOSSEN, KARL, UHLENBECK, OLKE C.

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Cloning and biochemical characterization of Bacillus subtilis YxiN, a DEAD protein specifically activated by 23S rRNA: Delineation of a novel sub-family of bacterial DEAD proteins von Kossen, Karl, Uhlenbeck, Olke C.

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Optimization of the multiple enzymatic activities of the hepatitis C virus NS3 protein von Misialek, Shawn, Rajagopalan, Ravi, Stevens, Sarah K., Beigelman, Leonid, Seiwert, Scott D., Kossen, Karl

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HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives von Wang, Guangyi, Lei, Huoxing, Wang, Xiaofang, Das, Debasis, Hong, Jian, Mackinnon, Colin H., Coulter, Thomas S., Montalbetti, Christian A.G.N., Mears, Richard, Gai, Xinjie, Bailey, Sarah E., Ruhrmund, Donald, Hooi, Lisa, Misialek, Shawn, Rajagopalan, P.T. Ravi, Cheng, Robert K.Y., Barker, John J., Felicetti, Brunella, Schönfeld, Dorian L., Stoycheva, Antitsa, Buckman, Brad O., Kossen, Karl, Seiwert, Scott D., Beigelman, Leonid

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Erratum: Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis von Fingerlin, Tasha E, Murphy, Elissa, Zhang, Weiming, Peljto, Anna L, Brown, Kevin K, Steele, Mark P, Loyd, James E, Cosgrove, Gregory P, Lynch, David, Groshong, Steve, Collard, Harold R, Wolters, Paul J, Bradford, Williamson Z, Kossen, Karl, Seiwert, Scott D, du Bois, Roland M, Garcia, Christine Kim, Devine, Megan S, Gudmundsson, Gunnar, Isaksson, Helgi J, Kaminski, Naftali, Zhang, Yingze, Gibson, Kevin F, Lancaster, Lisa H, Cogan, Joy D, Mason, Wendi R, Maher, Toby M, Molyneaux, Philip L, Wells, Athol U, Moffatt, Miriam F, Selman, Moises, Pardo, Annie, Kim, Dong Soon, Crapo, James D, Make, Barry J, Regan, Elizabeth A, Walek, Dinesha S, Daniel, Jerry J, Kamatani, Yoichiro, Zelenika, Diana, Smith, Keith, McKean, David, Pedersen, Brent S, Talbert, Janet, Kidd, Raven N, Markin, Cheryl R, Beckman, Kenneth B, Lathrop, Mark, Schwarz, Marvin I, Schwartz, David A

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