Systemic innate immune activation in food protein–induced enterocolitis syndrome von Goswami, Ritobrata, PhD, Blazquez, Ana Belen, PhD, Kosoy, Roman, PhD, Rahman, Adeeb, PhD, Nowak-Węgrzyn, Anna, MD, PhD, Berin, M. Cecilia, PhD

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Genetics of the human microglia regulome refines Alzheimer’s disease risk loci von Kosoy, Roman, Fullard, John F., Zeng, Biao, Bendl, Jaroslav, Dong, Pengfei, Rahman, Samir, Kleopoulos, Steven P., Shao, Zhiping, Girdhar, Kiran, Humphrey, Jack, de Paiva Lopes, Katia, Charney, Alexander W., Kopell, Brian H., Raj, Towfique, Bennett, David, Kellner, Christopher P., Haroutunian, Vahram, Hoffman, Gabriel E., Roussos, Panos

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Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America von Kosoy, Roman, Nassir, Rami, Tian, Chao, White, Phoebe A., Butler, Lesley M., Silva, Gabriel, Kittles, Rick, Alarcon‐Riquelme, Marta E., Gregersen, Peter K., Belmont, John W., De La Vega, Francisco M., Seldin, Michael F.

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Analysis of East Asia genetic substructure using genome-wide SNP arrays von Tian, Chao, Kosoy, Roman, Lee, Annette, Ransom, Michael, Belmont, John W, Gregersen, Peter K, Seldin, Michael F

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Multi-ancestry eQTL meta-analysis of human brain identifies candidate causal variants for brain-related traits von Zeng, Biao, Bendl, Jaroslav, Kosoy, Roman, Fullard, John F., Hoffman, Gabriel E., Roussos, Panos

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Relationship between hysterectomy and admixture in African American women von Qi, Lihong, PhD, Nassir, Rami, PhD, Kosoy, Roman, PhD, Garcia, Lorena, PhD, Waetjen, L. Elaine, MD, Ochs-Balcom, Heather M., PhD, Gass, Margery, MD, Robbins, John, MD, Seldin, Michael F., MD, PhD

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Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2–related Disease von Suárez-Fariñas, Mayte, Tokuyama, Minami, Wei, Gabrielle, Huang, Ruiqi, Livanos, Alexandra, Jha, Divya, Levescot, Anais, Irizar, Haritz, Kosoy, Roman, Cording, Sascha, Wang, Wenhui, Losic, Bojan, Ungaro, Ryan C., Di’Narzo, Antonio, Martinez-Delgado, Gustavo, Suprun, Maria, Corley, Michael J., Stojmirovic, Aleksandar, Houten, Sander M., Peters, Lauren, Curran, Mark, Brodmerkel, Carrie, Perrigoue, Jacqueline, Friedman, Joshua R., Hao, Ke, Schadt, Eric E., Zhu, Jun, Ko, Huaibin M., Cho, Judy, Dubinsky, Marla C., Sands, Bruce E., Ndhlovu, Lishomwa, Cerf-Bensusan, Nadine, Kasarskis, Andrew, Colombel, Jean-Frederic, Harpaz, Noam, Argmann, Carmen, Mehandru, Saurabh

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Integrative Analysis of the Inflammatory Bowel Disease Serum Metabolome Improves Our Understanding of Genetic Etiology and Points to Novel Putative Therapeutic Targets von Di'Narzo, Antonio F., Houten, Sander M., Kosoy, Roman, Huang, Ruiqi, Vaz, Frédéric M., Hou, Ruixue, Wei, Gabrielle, Wang, Wenhui, Comella, Phillip H., Dodatko, Tetyana, Rogatsky, Eduard, Stojmirovic, Aleksandar, Brodmerkel, Carrie, Perrigoue, Jacqueline, Hart, Amy, Curran, Mark, Friedman, Joshua R., Zhu, Jun, Agrawal, Manasi, Cho, Judy, Ungaro, Ryan, Dubinsky, Marla C., Sands, Bruce E., Suárez-Fariñas, Mayte, Schadt, Eric E., Colombel, Jean-Frédéric, Kasarskis, Andrew, Hao, Ke, Argmann, Carmen

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Biopsy and blood-based molecular biomarker of inflammation in IBD von Argmann, Carmen, Hou, Ruixue, Ungaro, Ryan C, Irizar, Haritz, Al-Taie, Zainab, Huang, Ruiqi, Kosoy, Roman, Venkat, Swati, Song, Won-Min, Di'Narzo, Antonio F, Losic, Bojan, Hao, Ke, Peters, Lauren, Comella, Phillip H, Wei, Gabrielle, Atreja, Ashish, Mahajan, Milind, Iuga, Alina, Desai, Prerak T, Branigan, Patrick, Stojmirovic, Aleksandar, Perrigoue, Jacqueline, Brodmerkel, Carrie, Curran, Mark, Friedman, Joshua R, Hart, Amy, Lamousé-Smith, Esi, Wehkamp, Jan, Mehandru, Saurabh, Schadt, Eric E, Sands, Bruce E, Dubinsky, Marla C, Colombel, Jean-Frederic, Kasarskis, Andrew, Suárez-Fariñas, Mayte

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Tyk2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits von Diogo, Dorothée, Bastarache, Lisa, Liao, Katherine P., Graham, Robert R., Fulton, Robert S., Greenberg, Jeffrey D., Eyre, Steve, Bowes, John, Cui, Jing, Lee, Annette, Pappas, Dimitrios A., Kremer, Joel M., Barton, Anne, Coenen, Marieke J. H., Franke, Barbara, Kiemeney, Lambertus A., Mariette, Xavier, Richard-Miceli, Corrine, Canhao, Helena, Fonseca, João, de Vries, Niek, Tak, Paul P., Crusius, J. Bart A., Nurmohamed, Michael T., Kurreeman, Fina, Mikuls, Ted R., Okada, Yukinori, Stahl, Eli A., Larson, David E., Deluca, Tracie L., O'Laughlin, Michelle, Fronick, Catrina C., Fulton, Lucinda L., Kosoy, Roman, Ransom, Michael, Bhangale, Tushar R., Ortmann, Ward, Cagan, Andrew, Gainer, Vivian, Karlson, Elizabeth W., Kohane, Isaac, Murphy, Shawn N., Martin, Javier, Zhernakova, Alexandra, Klareskog, Lars, Padyukov, Leonid, Worthington, Jane, Mardis, Elaine R., Seldin, Michael F., Gregersen, Peter K., Behrens, Timothy, Raychaudhuri, Soumya, Denny, Joshua C., Plenge, Robert M.

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Neuronal, glial and microglial maps of epigenetic and transcriptomics dysregulations in Alzheimer’s disease von Bendl, Jaroslav, Girdhar, Kiran, Hauberg, Mads E, Zeng, Biao, Kosoy, Roman, Dong, Pengfei, Rahman, Samir, Kleopoulos, Steven P, Voloudakis, Georgios, Hoffman, Gabriel E, Fullard, John F, Roussos, Panos

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Gut microbiota density influences host physiology and is shaped by host and microbial factors von Contijoch, Eduardo J, Britton, Graham J, Yang, Chao, Mogno, Ilaria, Li, Zhihua, Ng, Ruby, Llewellyn, Sean R, Hira, Sheela, Johnson, Crystal, Rabinowitz, Keren M, Barkan, Revital, Dotan, Iris, Hirten, Robert P, Fu, Shih-Chen, Luo, Yuying, Yang, Nancy, Luong, Tramy, Labrias, Philippe R, Lira, Sergio, Peter, Inga, Grinspan, Ari, Clemente, Jose C, Kosoy, Roman, Kim-Schulze, Seunghee, Qin, Xiaochen, Castillo, Anabella, Hurley, Amanda, Atreja, Ashish, Rogers, Jason, Fasihuddin, Farah, Saliaj, Merjona, Nolan, Amy, Reyes-Mercedes, Pamela, Rodriguez, Carina, Aly, Sarah, Santa-Cruz, Kenneth, Peters, Lauren, Suárez-Fariñas, Mayte, Huang, Ruiqi, Hao, Ke, Zhu, Jun, Zhang, Bin, Losic, Bojan, Irizar, Haritz, Song, Won-Min, Di Narzo, Antonio, Wang, Wenhui, Cohen, Benjamin L, DiMaio, Christopher, Greenwald, David, Itzkowitz, Steven, Lucas, Aimee, Marion, James, Maser, Elana, Ungaro, Ryan, Naymagon, Steven, Novak, Joshua, Shah, Brijen, Ullman, Thomas, Rubin, Peter, George, James, Legnani, Peter, Telesco, Shannon E, Friedman, Joshua R, Brodmerkel, Carrie, Plevy, Scott, Cho, Judy H, Colombel, Jean-Frederic, Schadt, Eric E, Argmann, Carmen, Dubinsky, Marla, Kasarskis, Andrew, Sands, Bruce, Faith, Jeremiah J

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Activity-Dependent Transcriptional Program in NGN2+ Neurons Enriched for Genetic Risk for Brain-Related Disorders von Ma, Yixuan, Bendl, Jaroslav, Hartley, Brigham J., Fullard, John F., Abdelaal, Rawan, Ho, Seok-Man, Kosoy, Roman, Gochman, Peter, Rapoport, Judith, Hoffman, Gabriel E., Brennand, Kristen J., Roussos, Panos

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Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis von Seldin, Michael F, Liu, Xiangdong, Invernizzi, Pietro, Lu, Yue, Kosoy, Roman, Lu, Yan, Bianchi, Ilaria, Podda, Mauro, Xu, Chun, Xie, Gang, Macciardi, Fabio, Selmi, Carlo, Lupoli, Sara, Shigeta, Russell, Ransom, Michael, Lleo, Ana, Lee, Annette T, Mason, Andrew L, Myers, Robert P, Peltekian, Kevork M, Ghent, Cameron N, Bernuzzi, Francesca, Zuin, Massimo, Rosina, Floriano, Borghesio, Elisabetta, Floreani, Annarosa, Lazzari, Roberta, Niro, Grazia, Andriulli, Angelo, Muratori, Luigi, Muratori, Paolo, Almasio, Piero L, Andreone, Pietro, Margotti, Marzia, Brunetto, Maurizia, Coco, Barbara, Alvaro, Domenico, Bragazzi, Maria C, Marra, Fabio, Pisano, Alessandro, Rigamonti, Cristina, Colombo, Massimo, Marzioni, Marco, Benedetti, Antonio, Fabris, Luca, Strazzabosco, Mario, Portincasa, Piero, Palmieri, Vincenzo O, Tiribelli, Claudio, Croce, Lory, Bruno, Savino, Rossi, Sonia, Vinci, Maria, Prisco, Cleofe, Mattalia, Alberto, Toniutto, Pierluigi, Picciotto, Antonio, Galli, Andrea, Ferrari, Carlo, Colombo, Silvia, Casella, Giovanni, Morini, Lorenzo, Caporaso, Nicola, Colli, Agostino, Spinzi, Giancarlo, Montanari, Renzo, Gregersen, Peter K, Heathcote, E Jenny, Hirschfield, Gideon M, Siminovitch, Katherine A, Amos, Christopher I, Gershwin, M Eric

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Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B08 von Gregersen, Peter K, Kosoy, Roman, Lee, Annette T, Lamb, Janine, Sussman, Jon, McKee, David, Simpfendorfer, Kim R, Pirskanen-Matell, Ritva, Piehl, Frederik, Pan-Hammarstrom, Qiang, Verschuuren, Jan J G M, Titulaer, Maarten J, Niks, Erik H, Marx, Alexander, Ströbel, Philipp, Tackenberg, Björn, Pütz, Michael, Maniaol, Angelina, Elsais, Ahmed, Tallaksen, Chantal, Harbo, Hanne F, Lie, Benedicte A, Raychaudhuri, Soumya, de Bakker, Paul I W, Melms, Arthur, Garchon, Henri-Jean, Willcox, Nicholas, Hammarstrom, Lennart, Seldin, Michael F

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Polygenic risk score for alcohol drinking behavior improves prediction of inflammatory bowel disease risk von Di Narzo, Antonio F, Hart, Amy, Kosoy, Roman, Peters, Lauren, Stojmirovic, Aleksandar, Cheng, Haoxiang, Zhang, Zhongyang, Shan, Mingxu, Cho, Judy, Kasarskis, Andrew, Argmann, Carmen, Peter, Inga, Schadt, Eric E, Hao, Ke

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Genome-wide analysis indicates association between heterozygote advantage and healthy aging in humans von Xu, Ke, Kosoy, Roman, Shameer, Khader, Kumar, Sudhir, Liu, Li, Readhead, Ben, Belbin, Gillian M, Lee, Hao-Chih, Chen, Rong, Dudley, Joel T

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Molecular Characterization of Limited Ulcerative Colitis Reveals Novel Biology and Predictors of Disease Extension von Argmann, Carmen, Tokuyama, Minami, Ungaro, Ryan C., Huang, Ruiqi, Hou, Ruixue, Gurunathan, Sakteesh, Kosoy, Roman, Di’Narzo, Antonio, Wang, Wenhui, Losic, Bojan, Irizar, Haritz, Peters, Lauren, Stojmirovic, Aleksandar, Wei, Gabrielle, Comella, Phillip H., Curran, Mark, Brodmerkel, Carrie, Friedman, Joshua R., Hao, Ke, Schadt, Eric E., Zhu, Jun, Cho, Judy, Harpaz, Noam, Dubinsky, Marla C., Sands, Bruce E., Kasarskis, Andrew, Mehandru, Saurabh, Colombel, Jean-Frederic, Suárez-Fariñas, Mayte

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Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 a... von Juran, Brian D, Hirschfield, Gideon M, Invernizzi, Pietro, Atkinson, Elizabeth J, Li, Yafang, Xie, Gang, Kosoy, Roman, Ransom, Michael, Sun, Ye, Bianchi, Ilaria, Schlicht, Erik M, Lleo, Ana, Coltescu, Catalina, Bernuzzi, Francesca, Podda, Mauro, Lammert, Craig, Shigeta, Russell, Chan, Landon L, Balschun, Tobias, Marconi, Maurizio, Cusi, Daniele, Heathcote, E Jenny, Mason, Andrew L, Myers, Robert P, Milkiewicz, Piotr, Odin, Joseph A, Luketic, Velimir A, Bacon, Bruce R, Bodenheimer, Jr, Henry C, Liakina, Valentina, Vincent, Catherine, Levy, Cynthia, Franke, Andre, Gregersen, Peter K, Bossa, Fabrizio, Gershwin, M Eric, deAndrade, Mariza, Amos, Christopher I, Lazaridis, Konstantinos N, Seldin, Michael F, Siminovitch, Katherine A

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620 A MOLECULAR NETWORK SURVEY PREDICTS NICKEL EXPOSURE AS A POTENTIAL ENVIRONMENTAL TRIGGER OF INFLAMMATORY BOWEL DISEASE von Wei, Gabrielle, Huang, Ruiqi, Kosoy, Roman, Di Narzo, Antonio F., Hao, Ke, Zhu, Jun, Dubinsky, Marla, Sands, Bruce E., Schadt, Eric E., Colombel, Jean Frederic, Cho, Judy H., Kasarskis, Andrew, Suarez-Farinas, Mayte, Argmann, Carmen A.

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