Symptomatic Improvement in Adults and Adolescents with Eosinophilic Esophagitis Requires Higher Systemic Dupilumab Exposure than Histologic Response von Dellon, Evan S, Kosloski, Matthew P, Shabbir, Arsalan, Glotfelty, Lila, Xu, Christine, Kamal, Mohamed A

Volltext

A Phase II Trial of Lutikizumab, an Anti–Interleukin‐1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis von Fleischmann, Roy M., Bliddal, Henning, Blanco, Francisco J., Schnitzer, Thomas J., Peterfy, Charles, Chen, Su, Wang, Li, Feng, Sheng, Conaghan, Philip G., Berenbaum, Francis, Pelletier, Jean‐Pierre, Martel‐Pelletier, Johanne, Vaeterlein, Ole, Kaeley, Gurjit S., Liu, Wei, Kosloski, Matthew P., Levy, Gwen, Zhang, Lanju, Medema, Jeroen K., Levesque, Marc C.

Volltext

Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis von Dellon, Evan S., Rothenberg, Marc E., Collins, Margaret H., Hirano, Ikuo, Chehade, Mirna, Bredenoord, Albert J., Lucendo, Alfredo J., Spergel, Jonathan M., Aceves, Seema, Sun, Xian, Kosloski, Matthew P., Kamal, Mohamed A., Hamilton, Jennifer D., Beazley, Bethany, McCann, Eilish, Patel, Kiran, Mannent, Leda P., Laws, Elizabeth, Akinlade, Bolanle, Amin, Nikhil, Lim, Wei Keat, Wipperman, Matthew F., Ruddy, Marcella, Patel, Naimish, Weinreich, David R., Yancopoulos, George D., Shumel, Brad, Maloney, Jennifer, Giannelou, Angeliki, Shabbir, Arsalan

Volltext

Delivery of Therapeutic Proteins von Pisal, Dipak S., Kosloski, Matthew P., Balu-Iyer, Sathy V.

Volltext

Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis: a randomised, double-blind, placebo-controlled, phase 3 trial von Paller, Amy S, Simpson, Eric L, Siegfried, Elaine C, Cork, Michael J, Wollenberg, Andreas, Arkwright, Peter D, Soong, Weily, Gonzalez, Mercedes E, Schneider, Lynda C, Sidbury, Robert, Lockshin, Benjamin, Meltzer, Steven, Wang, Zhixiao, Mannent, Leda P, Amin, Nikhil, Sun, Yiping, Laws, Elizabeth, Akinlade, Bolanle, Dillon, Myles, Kosloski, Matthew P, Kamal, Mohamed A, Dubost-Brama, Ariane, Patel, Naimish, Weinreich, David M, Yancopoulos, George D, O’Malley, John T, Bansal, Ashish, Pepper, Amber, Cohen, David, Pariser, David, Leflein, Jeffrey, Weinberg, Jeffrey, Browning, John, Teng, Joyce, Wine Lee, Lara, Sher, Lawrence, Diaz, Lucia, Schneider, Lynda, Rupp, Ned, Ong, Peck, Cartwright, Robert, Pinter, Andreas, Schnopp, Christina, Korkosz, Anna, Bystrzanowska, Dorota, Sygula, Ewa, Zdybski, Jacek, Padlewska, Kamila

Volltext

Characterizing complex and competing drug–drug interactions between the antiviral regimen of glecaprevir and pibrentasvir with rifampin or carbamazepine von Kosloski, Matthew P., Li, Hong, Wang, Stanley, Mensa, Federico, Kort, Jens, Liu, Wei

Volltext

Efficacy and Safety of Glecaprevir/Pibrentasvir in Patients Coinfected With Hepatitis C Virus and Human Immunodeficiency Virus Type 1: The EXPEDITION-2 Study von Rockstroh, Jürgen K, Lacombe, Karine, Viani, Rolando M, Orkin, Chloe, Wyles, David, Luetkemeyer, Anne F, Soto-Malave, Ruth, Flisiak, Robert, Bhagani, Sanjay, Sherman, Kenneth E, Shimonova, Tatiana, Ruane, Peter, Sasadeusz, Joseph, Slim, Jihad, Zhang, Zhenzhen, Samanta, Suvajit, Ng, Teresa I, Gulati, Abhishek, Kosloski, Matthew P, Shulman, Nancy S, Trinh, Roger, Sulkowski, Mark

Volltext

Long-Term Efficacy and Safety of Dupilumab in Adolescents with Moderate-to-Severe Atopic Dermatitis: Results Through Week 52 from a Phase III Open-Label Extension Trial (LIBERTY AD... von Blauvelt, Andrew, Guttman-Yassky, Emma, Paller, Amy S., Simpson, Eric L., Cork, Michael J., Weisman, Jamie, Browning, John, Soong, Weily, Sun, Xian, Chen, Zhen, Kosloski, Matthew P., Kamal, Mohamed A., Delevry, Dimittri, Chuang, Chien-Chia, O’Malley, John T., Bansal, Ashish

Volltext

Role of Glycosylation in Conformational Stability, Activity, Macromolecular Interaction and Immunogenicity of Recombinant Human Factor VIII von Kosloski, Matthew P., Miclea, Razvan D., Balu-Iyer, Sathy V.

Volltext

No Clinically Relevant Drug-Drug Interactions between Methadone or Buprenorphine-Naloxone and Antiviral Combination Glecaprevir and Pibrentasvir von Kosloski, Matthew P, Zhao, Weihan, Asatryan, Armen, Kort, Jens, Geoffroy, Pierre, Liu, Wei

Volltext

Dupilumab: Mechanism of action, clinical, and translational science von McCann, Marc R., Kosloski, Matthew P., Xu, Christine, Davis, John D., Kamal, Mohamed A.

Volltext

Subcutaneous Administration of Monoclonal Antibodies: Pharmacology, Delivery, Immunogenicity, and Learnings From Applications to Clinical Development von Davis, John D., Bravo Padros, Marçal, Conrado, Daniela J., Ganguly, Samit, Guan, Xiaowen, Hassan, Hazem E., Hazra, Anasuya, Irvin, Susan C., Jayachandran, Priya, Kosloski, Matthew P., Lin, Kuan‐Ju, Mukherjee, Kamalika, Paccaly, Anne, Papachristos, Apostolos, Partridge, Michael A., Prabhu, Saileta, Visich, Jennifer, Welf, Erik S., Xu, Xiaoying, Zhao, An, Zhu, Min

Volltext

Translation of In Vitro Transport Inhibition Studies to Clinical Drug-Drug Interactions for Glecaprevir and Pibrentasvir von Kosloski, Matthew P., Bow, Daniel A.J., Kikuchi, Ryota, Wang, Haoyu, Kim, Elaine J., Marsh, Kennan, Mensa, Federico, Kort, Jens, Liu, Wei

Volltext

Pharmacokinetics and pharmacodynamics of itepekimab in healthy adults and patients with asthma: Phase I first‐in‐human and first‐in‐patient trials von Kosloski, Matthew P., Kalliolias, George D., Xu, Christine R., Harel, Sivan, Lai, Ching‐Ha, Zheng, Wenjun, Davis, John D., Kamal, Mohamed A.

Volltext

Dupilumab for Eosinophilic Esophagitis in Patients 1 to 11 Years of Age von Chehade, Mirna, Dellon, Evan S., Spergel, Jonathan M., Collins, Margaret H., Rothenberg, Marc E., Pesek, Robert D., Hirano, Ikuo, Liu, Ruiqi, Laws, Elizabeth, Mortensen, Eric, Martincova, Renata, Shabbir, Arsalan, McCann, Eilish, Kamal, Mohamed A., Kosloski, Matthew P., Hamilton, Jennifer D., Samuely, Carin, Lim, Wei Keat, Wipperman, Matthew F., Farrell, Annamaria, Patel, Naimish, Yancopoulos, George D., Glotfelty, Lila, Maloney, Jennifer

Volltext

Effects of Renal Impairment and Hemodialysis on the Pharmacokinetics and Safety of the Glecaprevir and Pibrentasvir Combination in Hepatitis C Virus-Negative Subjects von Kosloski, Matthew P, Zhao, Weihan, Marbury, Thomas C, Preston, Richard A, Collins, Michael G, Pugatch, David, Mensa, Federico, Kort, Jens, Liu, Wei

Volltext

Integrated Exposure–Response of Dupilumab in Children, Adolescents, and Adults With Atopic Dermatitis Using Categorical and Continuous Efficacy Assessments: A Population Analysis von Briggs, Emily, Kamal, Mohamed A., Kosloski, Matthew P., Linsmeier, Ian, Jusko, Natalie, Dolphin, Nancy, Chittenden, Jason, Simpson, Eric L., Paller, Amy S., Siegfried, Elaine C., Shumel, Brad, Levit, Noah A., Bansal, Ashish, Davis, John D., Chapel, Sunny, Smith, David E., Huniti, Nidal

Volltext

Drug-Drug Interactions of Glecaprevir and Pibrentasvir Coadministered With Human Immunodeficiency Virus Antiretrovirals von Kosloski, Matthew P, Oberoi, Rajneet, Wang, Stanley, Viani, Rolando M, Asatryan, Armen, Hu, Beibei, Ding, Bifeng, Qi, Xin, Kim, Elaine J, Mensa, Federico, Kort, Jens, Liu, Wei

Volltext

Phase I safety and pharmacokinetics study of rovalpituzumab tesirine in Japanese patients with advanced, recurrent small cell lung cancer von Udagawa, Hibiki, Akamatsu, Hiroaki, Tanaka, Kentaro, Takeda, Masayuki, Kanda, Shintaro, Kirita, Keisuke, Teraoka, Shunsuke, Nakagawa, Kazuhiko, Fujiwara, Yutaka, Yasuda, Ikuko, Okubo, Sumiko, Shintani, Masayuki, Kosloski, Matthew P., Scripture, Charity, Tamura, Tomohide, Okamoto, Isamu

Volltext

Immunogenicity of dupilumab in adult and pediatric patients with atopic dermatitis von Kamal, Mohamed A, Kosloski, Matthew P, Lai, Ching-Ha, Partridge, Michael A, Rajadhyaksha, Manoj, Kanamaluru, Vanaja, Bansal, Ashish, Shabbir, Arsalan, Shumel, Brad, Ardeleanu, Marius, Richards, Susan M, Yan, Hong, Xu, Christine R, Rodríguez-Marco, Ainara, Xiao, Jing, Khokhar, Faisal A, Gherardi, Guy, Babilonia, Elisa, Maloney, Jennifer, Mortensen, Eric, Akinlade, Bolanle, Braunstein, Ned, Stahl, Neil, Torri, Albert, Davis, John D, DiCioccio, A Thomas

Volltext