Advances in the Enzymatic Reduction of Ketones von Moore, Jeffrey C, Pollard, David J, Kosjek, Birgit, Devine, Paul N

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CRTH2 Antagonist MK-7246: A Synthetic Evolution from Discovery through Development von Molinaro, Carmela, Bulger, Paul G, Lee, Ernest E, Kosjek, Birgit, Lau, Stephen, Gauvreau, Danny, Howard, Melissa E, Wallace, Debra J, O’Shea, Paul D

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Green and sustainable metrics: Charting the course for green-by-design small molecule API synthesis von Rose, Harrison B., Kosjek, Birgit, Armstrong, Brittany M., Robaire, Sandra A.

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Biocatalytic Asymmetric Hydrogen Transfer Employing Rhodococcus ruber DSM 44541 von Stampfer, Wolfgang, Kosjek, Birgit, Faber, Kurt, Kroutil, Wolfgang

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Purification and characterization of a chemotolerant alcohol dehydrogenase applicable to coupled redox reactions von Kosjek, Birgit, Stampfer, Wolfgang, Pogorevc, Mateja, Goessler, Walter, Faber, Kurt, Kroutil, Wolfgang

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Recent preparative applications of redox enzymes von Prier, Christopher K, Kosjek, Birgit

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Selective Synthesis of N 6,3′,5′-Tripivaloyladenosine via Dynamic Kinetic Crystallization and Regioselective Preparation of Pivalated 2′-Deoxy-2′-fluoroarabinoadenosines von Maligres, Peter E., Song, Zhiguo Jake, Chen, Lu, Kosjek, Birgit, Ad, Omer, Chung, Cheol K.

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Non-Racemic Halohydrins via Biocatalytic Hydrogen-Transfer Reduction of Halo-Ketones and One-Pot Cascade Reaction to Enantiopure Epoxides von Poessl, Tina M., Kosjek, Birgit, Ellmer, Ursula, Gruber, Christian C., Edegger, Klaus, Faber, Kurt, Hildebrandt, Petra, Bornscheuer, Uwe T., Kroutil, Wolfgang

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Driving Aspirational Process Mass Intensity Using Simple Structure-Based Prediction von Sherer, Edward C., Bagchi, Ansuman, Kosjek, Birgit, Maloney, Kevin M., Peng, Zhengwei, Robaire, Sandra A., Sheridan, Robert P., Metwally, Essam, Campeau, Louis-Charles

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Resolution of 2,2-Disubstituted Epoxides via Biocatalytic Azidolysis von Molinaro, Carmela, Guilbault, Audrey-Anne, Kosjek, Birgit

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Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1Process History and Development Strategy von DiRocco, Daniel A., Zhong, Yong-Li, Le, Diane N., McCann, Scott D., Hethcox, J. Caleb, Kim, Jungchul, Kolev, Joshua N., Kosjek, Birgit, Dalby, Stephen M., McMullen, Jonathan P., Gangam, Rekha, Morris, William J.

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Improved iGAL 2.0 Metric Empowers Pharmaceutical Scientists to Make Meaningful Contributions to United Nations Sustainable Development Goal 12 von Roschangar, Frank, Li, Jun, Zhou, Yanyan, Aelterman, Wim, Borovika, Alina, Colberg, Juan, Dickson, David P, Gallou, Fabrice, Hayler, John D, Koenig, Stefan G, Kopach, Michael E, Kosjek, Birgit, Leahy, David K, O’Brien, Erin, Smith, Austin G, Henry, Manuel, Cook, Jutta, Sheldon, Roger A

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Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 5Chemoenzymatic Diastereoselective Fluorination/DKR von McCann, Scott D., Dubina, Sean H., Kosjek, Birgit, Alwedi, Embarek, Behre, Taylor, Burgess, Samantha A., Dal Poggetto, Guilherme, DiRocco, Daniel A., Hartmanshenn, Clara, McMullen, Jonathan P., Padivitage, Nilusha, Sun, Alexandra C.

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Harnessing the Power of Catalysis for the Synthesis of CRTH2 Antagonist MK-1029 von Ruck, Rebecca T, Pan, Jun, Vaswani, Rishi G, Kosjek, Birgit, Strotman, Neil A, Cai, Chaoxian, Humphrey, Guy R

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Scalable Asymmetric Synthesis of MK-8998, a T‑Type Calcium Channel Antagonist von Zhong, Yong-Li, Moore, Jeffrey C, Shevlin, Michael, Shultz, C. Scott, Kosjek, Birgit, Chen, Yonggang, Janey, Jacob M, Tan, Lushi

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Biocatalytic oxidative kinetic resolution of sec-alcohols: stereocontrol through substrate-modification von Stampfer, Wolfgang, Kosjek, Birgit, Faber, Kurt, Kroutil, Wolfgang

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Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan von Cheung‐Lee, Wai Ling, Kolev, Joshua N., McIntosh, John A., Gil, Agnieszka A., Pan, Weilan, Xiao, Li, Velásquez, Juan E., Gangam, Rekha, Winston, Matthew S., Li, Shasha, Abe, Kotoe, Alwedi, Embarek, Dance, Zachary E. X., Fan, Haiyang, Hiraga, Kaori, Kim, Jungchul, Kosjek, Birgit, Le, Diane N., Marzijarani, Nastaran Salehi, Mattern, Keith, McMullen, Jonathan P., Narsimhan, Karthik, Vikram, Ajit, Wang, Wei, Yan, Jia‐Xuan, Yang, Rong‐Sheng, Zhang, Victoria, Zhong, Wendy, DiRocco, Daniel A., Morris, William J., Murphy, Grant S., Maloney, Kevin M.

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Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib von Chung, Cheol K, Bulger, Paul G, Kosjek, Birgit, Belyk, Kevin M, Rivera, Nelo, Scott, Mark E, Humphrey, Guy R, Limanto, John, Bachert, Donald C, Emerson, Khateeta M

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Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction von Xu, Feng, Kosjek, Birgit, Cabirol, Fabien L., Chen, Haibin, Desmond, Richard, Park, Jeonghan, Gohel, Anupam P., Collier, Steven J., Smith, Derek J., Liu, Zhuqing, Janey, Jacob M., Chung, John Y. L., Alvizo, Oscar

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MISER chromatography (multiple injections in a single experimental run): the chromatogram is the graph von Welch, Christopher J., Gong, Xiaoyi, Schafer, Wes, Pratt, Edwin C., Brkovic, Tanja, Pirzada, Zainab, Cuff, James F., Kosjek, Birgit

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