SP-0514: A radiobiologist’s perspective von Koritzinsky, M

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105: Reprogramming metabolism with metformin to improve radiation response von Koritzinsky, M

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SP-0628: Treatment strategies targeting tumor hypoxia von Koritzinsky, M

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SP-0458 Targeting metabolism to sensitize hypoxic tumor cells von Koritzinsky, M.

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A pilot ‘window of opportunity’ neoadjuvant study of metformin in localised prostate cancer von Joshua, A M, Zannella, V E, Downes, M R, Bowes, B, Hersey, K, Koritzinsky, M, Schwab, M, Hofmann, U, Evans, A, van der Kwast, T, Trachtenberg, J, Finelli, A, Fleshner, N, Sweet, J, Pollak, M

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Metformin with neoadjuvant chemoradiation to improve pathologic response in rectal cancer: A pilot phase I/II trial von Wong, C.S., Chu, W., Ashamalla, S., Fenech, D., Berry, S., Kiss, A., Koritzinsky, M.

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Hypoxia as a target for combined modality treatments von Wouters, B.G, Weppler, S.A, Koritzinsky, M, Landuyt, W, Nuyts, S, Theys, J, Chiu, R.K, Lambin, P

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204 High-throughput functional screening identifies the flavoreductase POR as a principal determinant of sensitivity to the hypoxia-targeting prodrug SN30000 von Hunter, F.W, Shalev, Z, Wang, J, Moffat, J, Katella, T, Koritzinsky, M, Wilson, W.R, Wouters, B.G

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SP-0352 Targeting mitochondrial activity with metformin to reduce tumor hypoxia and increase radiation response in non-diabetic patients: Importance of patient selection von Koritzinsky, M., Han, K., Bruce, J., Milosevic, M.

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The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5 von Rouschop, Kasper M A, van den Beucken, Twan, Dubois, Ludwig, Niessen, Hanneke, Bussink, Johan, Savelkouls, Kim, Keulers, Tom, Mujcic, Hilda, Landuyt, Willy, Voncken, Jan Willem, Lambin, Philippe, van der Kogel, Albert J, Koritzinsky, Marianne, Wouters, Bradly G

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Metformin and Prostate Cancer Radiation Therapy: Improved Outcomes Due to Enhanced Tumor Oxygenation von Dal Pra, A, Zannella, V, Glicksman, R, Sykes, J, Muaddi, H, Joshua, A.M, Wouters, B.G, Milosevic, M, Koritzinsky, M, Bristow, R.G

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355 HYPOXIA INHIBITS DISULFIDE BOND FORMATION AND PROTEIN FOLDING IN THE ENDOPLASMIC RETICULUM von Koritzinsky, M, Van den Beucken, T, Chu, K, Boutros, P.C, Braakman, I, Wouters, B.G

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A late need for oxygen von Baumann, Kim

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347 NOVEL MECHANISMS OF GENE REGULATION BY HYPOXIA von Prickaerts, P, Adriaens, M, Chan-Seng-Yue, M, Beck, T, Koritzinsky, M, Voncken, W, Wouters, B

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Dose- and Time-Dependent Changes in Gene Expression in Human Glioma Cells after Low Radiation Doses von Short, S. C., Buffa, F. M., Bourne, S., Koritzinsky, M., Wouters, B. G., Bentzen, S. M.

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ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth von Bi, Meixia, Naczki, Christine, Koritzinsky, Marianne, Fels, Diane, Blais, Jaime, Hu, Nianping, Harding, Heather, Novoa, Isabelle, Varia, Mahesh, Raleigh, James, Scheuner, Donalyn, Kaufman, Randal J, Bell, John, Ron, David, Wouters, Bradly G, Koumenis, Constantinos

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Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α von Koumenis, Constantinos, Naczki, Christine, Koritzinsky, Marianne, Rastani, Sally, Diehl, Alan, Sonenberg, Nahum, Koromilas, Antonis, Wouters, Bradly G.

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Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control von Koritzinsky, Marianne, Magagnin, Michaël G, van den Beucken, Twan, Seigneuric, Renaud, Savelkouls, Kim, Dostie, Josée, Pyronnet, Stéphane, Kaufman, Randal J, Weppler, Sherry A, Voncken, Jan Willem, Lambin, Philippe, Koumenis, Constantinos, Sonenberg, Nahum, Wouters, Bradly G

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Hypoxia-Mediated Down-Regulation of Bid and Bax in Tumors Occurs via Hypoxia-Inducible Factor 1-Dependent and -Independent Mechanisms and Contributes to Drug Resistance von Erler, Janine T., Cawthorne, Christopher J., Williams, Kaye J., Koritzinsky, Marianne, Wouters, Bradley G., Wilson, Clare, Miller, Crispin, Demonacos, Costas, Stratford, Ian J., Dive, Caroline

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Targeting Lactate Transporters MCT-1 and MCT-4 to Inhibit the Growth of Hypoxic HNSCC Cells In Vitro von Boasquevisque, P.H., Schoeneberger, V., Caporiccio, L., Vellanki, R.N., Koritzinsky, M., Wouters, B.G.

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