Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity von Vriens, Kim, Christen, Stefan, Parik, Sweta, Broekaert, Dorien, Yoshinaga, Kazuaki, Talebi, Ali, Dehairs, Jonas, Escalona-Noguero, Carmen, Schmieder, Roberta, Cornfield, Thomas, Charlton, Catriona, Romero-Pérez, Laura, Rossi, Matteo, Rinaldi, Gianmarco, Orth, Martin F., Boon, Ruben, Kerstens, Axelle, Kwan, Suet Ying, Faubert, Brandon, Méndez-Lucas, Andrés, Kopitz, Charlotte C., Chen, Ting, Fernandez-Garcia, Juan, Duarte, João A. G., Schmitz, Arndt A., Steigemann, Patrick, Najimi, Mustapha, Hägebarth, Andrea, Van Ginderachter, Jo A., Sokal, Etienne, Gotoh, Naohiro, Wong, Kwok-Kin, Verfaillie, Catherine, Derua, Rita, Munck, Sebastian, Yuneva, Mariia, Beretta, Laura, DeBerardinis, Ralph J., Swinnen, Johannes V., Hodson, Leanne, Cassiman, David, Verslype, Chris, Christian, Sven, Grünewald, Sylvia, Grünewald, Thomas G. P., Fendt, Sarah-Maria

Volltext

Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells von Basit, Farhan, van Oppen, Lisanne MPE, Schöckel, Laura, Bossenbroek, Hasse M, van Emst-de Vries, Sjenet E, Hermeling, Johannes CW, Grefte, Sander, Kopitz, Charlotte, Heroult, Melanie, HGM Willems, Peter, Koopman, Werner JH

Volltext

Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance von Quanz, Maria, Bender, Eckhard, Kopitz, Charlotte, Grünewald, Sylvia, Schlicker, Andreas, Schwede, Wolfgang, Eheim, Ashley, Toschi, Luisella, Neuhaus, Roland, Richter, Carmen, Toedling, Joern, Merz, Claudia, Lesche, Ralf, Kamburov, Atanas, Siebeneicher, Holger, Bauser, Marcus, Hägebarth, Andrea

Volltext

Preclinical Efficacy of the Auristatin-Based Antibody-Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors von Sommer, Anette, Kopitz, Charlotte, Schatz, Christoph A, Nising, Carl F, Mahlert, Christoph, Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Hammer, Stefanie, Greven, Simone, Schuhmacher, Joachim, Braun, Manuela, Zierz, Ruprecht, Wittemer-Rump, Sabine, Harrenga, Axel, Dittmer, Frank, Reetz, Frank, Apeler, Heiner, Jautelat, Rolf, Huynh, Hung, Ziegelbauer, Karl, Kreft, Bertolt

Volltext

Preclinical Antitumor Efficacy of BAY 1129980-a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody-Drug Conjugate for the Treatment of Non-Small Cell Lung Cancer von Willuda, Jörg, Linden, Lars, Lerchen, Hans-Georg, Kopitz, Charlotte, Stelte-Ludwig, Beatrix, Pena, Carol, Lange, Claudia, Golfier, Sven, Kneip, Christoph, Carrigan, Patricia E, Mclean, Kirk, Schuhmacher, Joachim, von Ahsen, Oliver, Müller, Jörg, Dittmer, Frank, Beier, Rudolf, El Sheikh, Sherif, Tebbe, Jan, Leder, Gabriele, Apeler, Heiner, Jautelat, Rolf, Ziegelbauer, Karl, Kreft, Bertolt

Volltext

Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth von Schöckel, Laura, Glasauer, Andrea, Basit, Farhan, Bitschar, Katharina, Truong, Hoa, Erdmann, Gerrit, Algire, Carolyn, Hägebarth, Andrea, Willems, Peter Hgm, Kopitz, Charlotte, Koopman, Werner Jh, Héroult, Mélanie

Volltext

Therapeutic mechanism and efficacy of the antibody-drug conjugate BAY 79-4620 targeting human carbonic anhydrase 9 von Petrul, Heike M, Schatz, Christoph A, Kopitz, Charlotte C, Adnane, Lila, McCabe, Timothy J, Trail, Pamela, Ha, Sha, Chang, Yong S, Voznesensky, Andrei, Ranges, Gerald, Tamburini, Paul P

Volltext

Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling von KOPITZ, Charlotte, GERG, Michael, NAGASE, Hideaki, STANGI, Manfred, VON WEYHERN, Claus W. Hann, BRÜCHER, Björn L. D. M, BRAND, Karsten, COUSSENS, Lisa M, EDWARDS, Dylan R, KRÜGER, Achim, BANDAPALLI, Obul Reddy, ISTER, Dilek, PENNINGTON, Caroline J, HAUSER, Stephanie, FLECHSIG, Christin, KRELL, Hans-Willi, ANTOLOVIC, Dalibor, BREW, Keith

Volltext

Antimetastatic activity of a novel mechanism-based gelatinase inhibitor von KRÜGER, Achim, ANT, Matthias J. E, GERG, Michael, KOPITZ, Charlotte, MARGARIDA BERNARDO, M, CHANG, Mayland, MOBASHERY, Shahriar, FRIDMAN, Rafael

Volltext

Reduction of experimental human fibrosarcoma lung metastasis in mice by adenovirus-mediated cystatin C overexpression in the host von KOPITZ, Charlotte, ANTON, Martina, GANSBACHER, Bernd, KRÜGER, Achim

Volltext

Tissue inhibitor of metalloproteinases‐1‐induced scattered liver metastasis is mediated by host‐derived urokinase‐type plasminogen activator von Schrötzlmair, Florian, Kopitz, Charlotte, Halbgewachs, Birgit, Lu, Fei, Algül, Hana, Brünner, Nils, Gänsbacher, Bernd, Krüger, Achim

Volltext

Rogaratinib: A potent and selective pan‐FGFR inhibitor with broad antitumor activity in FGFR‐overexpressing preclinical cancer models von Grünewald, Sylvia, Politz, Oliver, Bender, Sebastian, Héroult, Mélanie, Lustig, Klemens, Thuss, Uwe, Kneip, Christoph, Kopitz, Charlotte, Zopf, Dieter, Collin, Marie‐Pierre, Boemer, Ulf, Ince, Stuart, Ellinghaus, Peter, Mumberg, Dominik, Hess‐Stumpp, Holger, Ziegelbauer, Karl

Volltext

Anetumab ravtansine: a novel mesothelin-targeting antibody-drug conjugate cures tumors with heterogeneous target expression favored by bystander effect von Golfier, Sven, Kopitz, Charlotte, Kahnert, Antje, Heisler, Iring, Schatz, Christoph A, Stelte-Ludwig, Beatrix, Mayer-Bartschmid, Anke, Unterschemmann, Kerstin, Bruder, Sandra, Linden, Lars, Harrenga, Axel, Hauff, Peter, Scholle, Frank-Detlef, Müller-Tiemann, Beate, Kreft, Bertolt, Ziegelbauer, Karl

Volltext

Distinct Functionality of Tumor Cell–Derived Gelatinases during Formation of Liver Metastases von Gerg, Michael, Kopitz, Charlotte, Schaten, Susanne, Tschukes, Alexander, Kahlert, Christoph, Stangl, Manfred, von Weyhern, Claus W Hann, Brücher, Björn L D M, Edwards, Dylan R, Brand, Karsten, Krüger, Achim

Volltext

Abstract 1314: A novel small molecule drug conjugate -avb3 integrin antagonist linked to a cytotoxic camptothecin derivative- for the treatment of multiple cancer types von Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Kopitz, Charlotte, Heroult, Melanie, Zubov, Dmitry, Willuda, Joerg, Schlange, Thomas, Kahnert, Antje, Izumi, Raquel, Hamdy, Ahmed

Volltext

EXTH-38. VELCRIN MOLECULAR GLUES INDUCE CELL DEATH IN GLIOBLASTOMAS WITH HIGH PDE3A AND SLFN12 EXPRESSION von Aquilanti, Elisa, Goldoni, Silvia, Baker, Andrew, Kotynkova, Kristina, Andersen, Sawyer, Gao, Galen, Cherniack, Andrew, Lange, Martin, Kopitz, Charlotte, Lienau, Philip, Lewis, Timothy, Garrido, Marine, Gradl, Stefan, Seidel, Henrik, Ligon, Keith, Wen, Patrick, Meyerson, Matthew, Greulich, Heidi

Volltext

Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12 von Wu, Xiaoyun, Schnitzler, Gavin R., Gao, Galen F., Diamond, Brett, Baker, Andrew R., Kaplan, Bethany, Williamson, Kaylyn, Westlake, Lindsay, Lorrey, Selena, Lewis, Timothy A., Garvie, Colin W., Lange, Martin, Hayat, Sikander, Seidel, Henrik, Doench, John, Cherniack, Andrew D., Kopitz, Charlotte, Meyerson, Matthew, Greulich, Heidi

Volltext

Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling von Graham, Keith, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Naujoks, Jan, Lesche, Ralf, Weiske, Joerg, Kuehnlenz, Julia, Brzezinka, Krzysztof, Potze, Lisette, Zanconato, Francesca, Nicke, Barbara, Montebaur, Anna, Bone, Wilhelm, Golfier, Sven, Kaulfuss, Stefan, Kopitz, Charlotte, Pilari, Sabine, Steuber, Holger, Hayat, Sikander, Kamburov, Atanas, Steffen, Andreas, Schlicker, Andreas, Buchgraber, Philipp, Braeuer, Nico, Font, Nuria Aiguabella, Heinrich, Tobias, Kuhnke, Lara, Nowak-Reppel, Katrin, Stresemann, Carlo, Steigemann, Patrick, Walter, Annette O., Blotta, Simona, Ocker, Matthias, Lakner, Ashley, von Nussbaum, Franz, Mumberg, Dominik, Eis, Knut, Piccolo, Stefano, Lange, Martin

Volltext

Abstract 665: Inhibition of mitochondrial complex I enhances the therapeutic benefit of BRAF inhibition in mutant melanoma cell lines von Schoeckel, Laura, Bitschar, Katharina, Héroult, Mélanie, Kopitz, Charlotte, Hägebarth, Andrea

Volltext

Discovery of BAY 2666605, a Molecular Glue for PDE3A and SLFN12 von Lewis, Timothy A., Ellermann, Manuel, Kopitz, Charlotte, Lange, Martin, de Waal, Luc, Wu, Xiaoyun, Tersteegen, Adrian, Denner, Karsten, Lienau, Philip, Kaulfuss, Stefan, Goldoni, Silvia, Meyerson, Matthew, Greulich, Heidi, Gradl, Stefan N.

Volltext