MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition von Vande Walle, Lieselotte, Stowe, Irma B, Šácha, Pavel, Lee, Bettina L, Demon, Dieter, Fossoul, Amelie, Van Hauwermeiren, Filip, Saavedra, Pedro H V, Šimon, Petr, Šubrt, Vladimír, Kostka, Libor, Stivala, Craig E, Pham, Victoria C, Staben, Steven T, Yamazoe, Sayumi, Konvalinka, Jan, Kayagaki, Nobuhiko, Lamkanfi, Mohamed

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The yeast proteases Ddi1 and Wss1 are both involved in the DNA replication stress response von Svoboda, Michal, Konvalinka, Jan, Trempe, Jean-François, Grantz Saskova, Klara

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Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors von Zima, Václav, Radilová, Kateřina, Kožíšek, Milan, Albiñana, Carlos Berenguer, Karlukova, Elena, Brynda, Jiří, Fanfrlík, Jindřich, Flieger, Miroslav, Hodek, Jan, Weber, Jan, Majer, Pavel, Konvalinka, Jan, Machara, Aleš

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Structural and Thermodynamic Analysis of the Resistance Development to Pimodivir (VX-787), the Clinical Inhibitor of Cap Binding to PB2 Subunit of Influenza A Polymerase von Gregor, Jiří, Radilová, Kateřina, Brynda, Jiří, Fanfrlík, Jindřich, Konvalinka, Jan, Kožíšek, Milan

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Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery von Kryštůfek, Robin, Šácha, Pavel, Starková, Jana, Brynda, Jiří, Hradilek, Martin, Tloušt’ová, Eva, Grzymska, Justyna, Rut, Wioletta, Boucher, Michael J, Drąg, Marcin, Majer, Pavel, Hájek, Miroslav, Řezáčová, Pavlína, Madhani, Hiten D, Craik, Charles S, Konvalinka, Jan

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Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer von Mesters, Jeroen R, Barinka, Cyril, Li, Weixing, Tsukamoto, Takashi, Majer, Pavel, Slusher, Barbara S, Konvalinka, Jan, Hilgenfeld, Rolf

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Malonate-based inhibitors of mammalian serine racemase: Kinetic characterization and structure-based computational study von Vorlová, Barbora, Nachtigallová, Dana, Jirásková-Vaníčková, Jana, Ajani, Haresh, Jansa, Petr, Řezáč, Jan, Fanfrlík, Jindřich, Otyepka, Michal, Hobza, Pavel, Konvalinka, Jan, Lepšík, Martin

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structural characterization of the interaction between the C-terminal domain of the influenza polymerase PA subunit and an optimized small peptide inhibitor von Hejdánek, Jakub, Radilová, Kateřina, Pachl, Petr, Hodek, Jan, Machara, Aleš, Weber, Jan, Řezáčová, Pavlína, Konvalinka, Jan, Kožíšek, Milan

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Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors von Reiberger, Robert, Radilová, Kateřina, Kráľ, Michal, Zima, Václav, Majer, Pavel, Brynda, Jiří, Dračínský, Martin, Konvalinka, Jan, Kožíšek, Milan, Machara, Aleš

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Factors, associated with elevated concentration of soluble carbonic anhydrase IX in plasma of women with cervical dysplasia von Grincevičienė, Švitrigailė, Vaitkienė, Daiva, Kanopienė, Daiva, Vansevičiūtė, Rasa, Tykvart, Jan, Sukovas, Artūras, Celiešiūtė, Joana, Ivanauskaitė Didžiokienė, Ernesta, Čižauskas, Arvydas, Laurinavičienė, Aida, Král, Vlastimil, Hlavačková, Anna, Zemanová, Jitka, Stravinskienė, Dovilė, Sližienė, Aistė, Petrošiūtė, Agnė, Petrauskas, Vytautas, Balsytė, Renata, Grincevičius, Jonas, Navratil, Vaclav, Jahn, Ullrich, Konvalinka, Jan, Žvirblienė, Aurelija, Matulis, Daumantas, Matulienė, Jurgita

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Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog von Sivá, Monika, Svoboda, Michal, Veverka, Václav, Trempe, Jean-François, Hofmann, Kay, Kožíšek, Milan, Hexnerová, Rozálie, Sedlák, František, Belza, Jan, Brynda, Jiří, Šácha, Pavel, Hubálek, Martin, Starková, Jana, Flaisigová, Iva, Konvalinka, Jan, Šašková, Klára Grantz

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Specific Inhibitors of HIV Capsid Assembly Binding to the C‑Terminal Domain of the Capsid Protein: Evaluation of 2‑Arylquinazolines as Potential Antiviral Compounds von Machara, Aleš, Lux, Vanda, Kožíšek, Milan, Grantz Šašková, Klára, Štěpánek, Ondřej, Kotora, Martin, Parkan, Kamil, Pávová, Marcela, Glass, Bärbel, Sehr, Peter, Lewis, Joe, Müller, Barbara, Kräusslich, Hans-Georg, Konvalinka, Jan

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From Nonpeptide toward Noncarbon Protease Inhibitors: Metallacarboranes as Specific and Potent Inhibitors of HIV Protease von Petr Cígler, Milan Kožíšek, Pavlína Řezáčová, Jíří Brynda, Otwinowski, Zbyszek, Jana Pokorná, Jaromír Plešek, Bohumír Grüner, Lucie Dolečková-Marešová, Martin Máša, Juraj Sedláček, Jochen Bodem, Kräusslich, Hans-Georg, Král, Vladimír, Jan Konvalinka

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Thermodynamic and structural analysis of HIV protease resistance to darunavir – analysis of heavily mutated patient‐derived HIV‐1 proteases von Kožíšek, Milan, Lepšík, Martin, Grantz Šašková, Klára, Brynda, Jiří, Konvalinka, Jan, Řezáčová, Pavlína

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Design of HIV Protease Inhibitors Based on Inorganic Polyhedral Metallacarboranes von Řezáčová, Pavlína, Pokorná, Jana, Brynda, Jiří, Kožíšek, Milan, Cígler, Petr, Lepšík, Martin, Fanfrlík, Jindřich, Řezáč, Jan, Grantz Šašková, Klára, Sieglová, Irena, Plešek, Jaromír, Šícha, Václav, Grüner, Bohumír, Oberwinkler, Heike, Sedláček’, Juraj, Kräusslich, Hans-Georg, Hobza, Pavel, Král, Vladimír, Konvalinka, Jan

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Current and Novel Inhibitors of HIV Protease von Pokorná, Jana, Machala, Ladislav, Rezáčová, Pavlína, Konvalinka, Jan

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DDI2 protease controls embryonic development and inflammation via TCF11/NRF1 von Nedomova, Monika, Haberecht-Müller, Stefanie, Möller, Sophie, Venz, Simone, Prochazkova, Michaela, Prochazka, Jan, Sedlak, Frantisek, Chawengsaksophak, Kallayanee, Hammer, Elke, Kasparek, Petr, Adamek, Michael, Sedlacek, Radislav, Konvalinka, Jan, Krüger, Elke, Grantz Saskova, Klara

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Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus von Pokorná, Jana, Pachl, Petr, Karlukova, Elena, Hejdánek, Jakub, Řezáčová, Pavlína, Machara, Aleš, Hudlický, Jason, Konvalinka, Jan, Kožíšek, Milan

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Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor von Schimer, Jiří, Pávová, Marcela, Anders, Maria, Pachl, Petr, Šácha, Pavel, Cígler, Petr, Weber, Jan, Majer, Pavel, Řezáčová, Pavlína, Kräusslich, Hans-Georg, Müller, Barbara, Konvalinka, Jan

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Viral proteases as therapeutic targets von Majerová, Taťána, Konvalinka, Jan

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