The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease von Neumann, Ulf, Ufer, Mike, Jacobson, Laura H, Rouzade‐Dominguez, Marie‐Laure, Huledal, Gunilla, Kolly, Carine, Lüönd, Rainer M, Machauer, Rainer, Veenstra, Siem J, Hurth, Konstanze, Rueeger, Heinrich, Tintelnot‐Blomley, Marina, Staufenbiel, Matthias, Shimshek, Derya R, Perrot, Ludovic, Frieauff, Wilfried, Dubost, Valerie, Schiller, Hilmar, Vogg, Barbara, Beltz, Karen, Avrameas, Alexandre, Kretz, Sandrine, Pezous, Nicole, Rondeau, Jean‐Michel, Beckmann, Nicolau, Hartmann, Andreas, Vormfelde, Stefan, David, Olivier J, Galli, Bruno, Ramos, Rita, Graf, Ana, Lopez Lopez, Cristina

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Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β von Hommel, Ulrich, Hurth, Konstanze, Rondeau, Jean-Michel, Vulpetti, Anna, Ostermeier, Daniela, Boettcher, Andreas, Brady, Jacob Peter, Hediger, Michael, Lehmann, Sylvie, Koch, Elke, Blechschmidt, Anke, Yamamoto, Rina, Tundo Dottorello, Valentina, Haenni-Holzinger, Sandra, Kaiser, Christian, Lehr, Philipp, Lingel, Andreas, Mureddu, Luca, Schleberger, Christian, Blank, Jutta, Ramage, Paul, Freuler, Felix, Eder, Joerg, Bornancin, Frédéric

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Gamma-lactams—A novel scaffold for highly potent and selective α7 nicotinic acetylcholine receptor agonists von Enz, Albert, Feuerbach, Dominik, Frederiksen, Mathias U., Gentsch, Conrad, Hurth, Konstanze, Müller, Werner, Nozulak, Joachim, Roy, Bernard L.

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Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious beta-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease von Machauer, Rainer, Lueoend, Rainer, Hurth, Konstanze, Veenstra, Siem J., Rueeger, Heinrich, Voegtle, Markus, Tintelnot-Blomley, Marina, Rondeau, Jean-Michel, Jacobson, Laura H., Laue, Grit, Beltz, Karen, Neumann, Ulf

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Synthesis of the Potent, Selective, and Efficacious β‑Secretase (BACE1) Inhibitor NB-360 von Rueeger, Heinrich, Lueoend, Rainer, Machauer, Rainer, Veenstra, Siem J, Holzer, Philipp, Hurth, Konstanze, Voegtle, Markus, Frederiksen, Mathias, Rondeau, Jean-Michel, Tintelnot-Blomley, Marina, Jacobson, Laura H, Staufenbiel, Matthias, Laue, Grit, Neumann, Ulf

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Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches von Vulpetti, Anna, Rondeau, Jean-Michel, Bellance, Marie-Hélène, Blank, Jutta, Boesch, Ralf, Boettcher, Andreas, Bornancin, Frédéric, Buhr, Sylvia, Connor, Lauren E., Dumelin, Christoph E., Esser, Oliver, Hediger, Michael, Hintermann, Samuel, Hommel, Ulrich, Koch, Elke, Lapointe, Guillaume, Leder, Lukas, Lehmann, Sylvie, Lehr, Philipp, Meier, Peter, Muller, Lionel, Ostermeier, Daniela, Ramage, Paul, Schiebel-Haddad, Sihame, Smith, Alexander Baxter, Stojanovic, Aleksandar, Velcicky, Juraj, Yamamoto, Rina, Hurth, Konstanze

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AQW051, a novel, potent and selective α7 nicotinic ACh receptor partial agonist: pharmacological characterization and phase I evaluation von Feuerbach, Dominik, Pezous, Nicole, Weiss, Markus, Shakeri‐Nejad, Kasra, Lingenhoehl, Kurt, Hoyer, Daniel, Hurth, Konstanze, Bilbe, Graeme, Pryce, Christopher R, McAllister, Kevin, Chaperon, Frederique, Kucher, Klaus, Johns, Donald, Blaettler, Thomas, Lopez Lopez, Cristina

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Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors von Veenstra, Siem Jakob, Rueeger, Heinrich, Voegtle, Markus, Lueoend, Rainer, Holzer, Philipp, Hurth, Konstanze, Tintelnot-Blomley, Marina, Frederiksen, Mathias, Rondeau, Jean-Michel, Jacobson, Laura, Staufenbiel, Matthias, Neumann, Ulf, Machauer, Rainer

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Regioselective nitration of 3-fluoro-2-substituted benzoic acids von Hurth, Konstanze, Jacquier, Sébastien, Lehmann, Hansjörg, Wilcken, Rainer

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Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst(3) receptor antagonists von Troxler, Thomas, Hurth, Konstanze, Schuh, Karl-Heinrich, Schoeffter, Philippe, Langenegger, Daniel, Enz, Albert, Hoyer, Daniel

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AQW 051, a novel, potent and selective α 7 nicotinic ACh receptor partial agonist: pharmacological characterization and phase I evaluation von Feuerbach, Dominik, Pezous, Nicole, Weiss, Markus, Shakeri‐Nejad, Kasra, Lingenhoehl, Kurt, Hoyer, Daniel, Hurth, Konstanze, Bilbe, Graeme, Pryce, Christopher R, McAllister, Kevin, Chaperon, Frederique, Kucher, Klaus, Johns, Donald, Blaettler, Thomas, Lopez Lopez, Cristina

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AQW051, a novel, potent and selective [alpha]7 nicotinic ACh receptor partial agonist: pharmacological characterization and phase I evaluation von Feuerbach, Dominik, Pezous, Nicole, Weiss, Markus, Shakeri-Nejad, Kasra, Lingenhoehl, Kurt, Hoyer, Daniel, Hurth, Konstanze, Bilbe, Graeme, Pryce, Christopher R, McAllister, Kevin, Chaperon, Frederique, Kucher, Klaus, Johns, Donald, Blaettler, Thomas, Lopez Lopez, Cristina

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Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists von Enz, Albert, Feuerbach, Dominik, Frederiksen, Mathias U, Gentsch, Conrad, Hurth, Konstanze, Müller, Werner, Nozulak, Joachim, Roy, Bernard L

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The BACE ‐1 inhibitor CNP 520 for prevention trials in Alzheimer's disease von Neumann, Ulf, Ufer, Mike, Jacobson, Laura H, Rouzade‐Dominguez, Marie‐Laure, Huledal, Gunilla, Kolly, Carine, Lüönd, Rainer M, Machauer, Rainer, Veenstra, Siem J, Hurth, Konstanze, Rueeger, Heinrich, Tintelnot‐Blomley, Marina, Staufenbiel, Matthias, Shimshek, Derya R, Perrot, Ludovic, Frieauff, Wilfried, Dubost, Valerie, Schiller, Hilmar, Vogg, Barbara, Beltz, Karen, Avrameas, Alexandre, Kretz, Sandrine, Pezous, Nicole, Rondeau, Jean‐Michel, Beckmann, Nicolau, Hartmann, Andreas, Vormfelde, Stefan, David, Olivier J, Galli, Bruno, Ramos, Rita, Graf, Ana, Lopez Lopez, Cristina

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Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst3 receptor antagonists von TROXLER, Thomas, HURTH, Konstanze, SCHUH, Karl-Heinrich, SCHOEFFTER, Philippe, LANGENEGGER, Daniel, ENZ, Albert, HOYER, Daniel

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Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABA A receptor von Hintermann, Samuel, Hurth, Konstanze, Nozulak, Joachim, Tintelnot-Blomley, Marina, Aichholz, Reiner, Blanz, Joachim, Kaupmann, Klemens, Mosbacher, Johannes

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Discovery of novel non-peptidic beta-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor anta... von Troxler, Thomas, Hurth, Konstanze, Mattes, Henri, Prashad, Mahavir, Schoeffter, Philippe, Langenegger, Daniel, Enz, Albert, Hoyer, Daniel

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Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABAA receptor von HINTERMANN, Samuel, HURTH, Konstanze, NOZULAK, Joachim, TINTELNOT-BLOMLEY, Marina, AICHHOLZ, Reiner, BLANZ, Joachim, KAUPMANN, Klemens, MOSBACHER, Johannes

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NMR Reporter Screening for the Detection of High-Affinity Ligands von Jahnke, Wolfgang, Floersheim, Philipp, Ostermeier, Christian, Zhang, Xiaolu, Hemmig, Rene, Hurth, Konstanze, Uzunov, Doncho P.

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Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABA sub(A receptor) von Hintermann, Samuel, Hurth, Konstanze, Nozulak, Joachim, Tintelnot-Blomley, Marina, Aichholz, Reiner, Blanz, Joachim, Kaupmann, Klemens, Mosbacher, Johannes

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