Innovative Therapeutic Approaches for Huntington's Disease: From Nucleic Acids to GPCR-Targeting Small Molecules von Komatsu, Hidetoshi

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Novel Therapeutic GPCRs for Psychiatric Disorders von Komatsu, Hidetoshi

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Potential Utility of Biased GPCR Signaling for Treatment of Psychiatric Disorders von Komatsu, Hidetoshi, Fukuchi, Mamoru, Habata, Yugo

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Psychiatric Neural Networks and Precision Therapeutics by Machine Learning von Komatsu, Hidetoshi, Watanabe, Emi, Fukuchi, Mamoru

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Discovery of the First Druggable GPR52 Antagonist to Treat Huntington’s Disease von Komatsu, Hidetoshi

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A novel antidiabetic drug, fasiglifam/TAK-875, acts as an ago-allosteric modulator of FFAR1 von Yabuki, Chiori, Komatsu, Hidetoshi, Tsujihata, Yoshiyuki, Maeda, Risa, Ito, Ryo, Matsuda-Nagasumi, Kae, Sakuma, Kensuke, Miyawaki, Kazumasa, Kikuchi, Naoya, Takeuchi, Koji, Habata, Yugo, Mori, Masaaki

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Temporal and spatial transcriptional fingerprints by antipsychotic or propsychotic drugs in mouse brain von Sakuma, Kensuke, Komatsu, Hidetoshi, Maruyama, Minoru, Imaichi, Sachiko, Habata, Yugo, Mori, Masaaki

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Anatomical transcriptome of G protein-coupled receptors leads to the identification of a novel therapeutic candidate GPR52 for psychiatric disorders von Komatsu, Hidetoshi, Maruyama, Minoru, Yao, Shuuhei, Shinohara, Tokuyuki, Sakuma, Kensuke, Imaichi, Sachiko, Chikatsu, Tomoko, Kuniyeda, Kanako, Siu, Foo Kok, Peng, Lam Sock, Zhuo, Katherine, Mun, Lay Sock, Han, Tan Min, Matsumoto, Yoshio, Hashimoto, Tadatoshi, Miyajima, Nobuyuki, Itoh, Yasuaki, Ogi, Kazuhiro, Habata, Yugo, Mori, Masaaki

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C. elegans Notch Signaling Regulates Adult Chemosensory Response and Larval Molting Quiescence von Singh, Komudi, Chao, Michael Y., Somers, Gerard A., Komatsu, Hidetoshi, Corkins, Mark E., Larkins-Ford, Jonah, Tucey, Tim, Dionne, Heather M., Walsh, Melissa B., Beaumont, Emma K., Hart, Douglas P., Lockery, Shawn R., Hart, Anne C.

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Feeding Status and Serotonin Rapidly and Reversibly Modulate a Caenorhabditis elegans Chemosensory Circuit von Chao, Michael Y., Komatsu, Hidetoshi, Fukuto, Hana S., Dionne, Heather M., Hart, Anne C., Bargmann, Cornelia I.

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OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development von Komatsu, Hidetoshi, Chao, Michael Y, Larkins-Ford, Jonah, Corkins, Mark E, Somers, Gerard A, Tucey, Tim, Dionne, Heather M, White, Jamie Q, Wani, Khursheed, Boxem, Mike, Hart, Anne C

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A New Peptidic Ligand and Its Receptor Regulating Adrenal Function in Rats von Fukusumi, Shoji, Yoshida, Hiromi, Fujii, Ryo, Maruyama, Minoru, Komatsu, Hidetoshi, Habata, Yugo, Shintani, Yasushi, Hinuma, Shuji, Fujino, Masahiko

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Mutations in a Cyclic Nucleotide–Gated Channel Lead to Abnormal Thermosensation and Chemosensation in C. elegans von Komatsu, Hidetoshi, Mori, Ikue, Rhee, Jeong-Seop, Akaike, Norio, Ohshima, Yasumi

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FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia von Nishiyama, Keiji, Suzuki, Hirobumi, Harasawa, Toshiya, Suzuki, Noriko, Kurimoto, Emi, Kawai, Takayuki, Maruyama, Minoru, Komatsu, Hidetoshi, Sakuma, Kensuke, Shimizu, Yuji, Shimojo, Masato

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Functional reconstitution of a heteromeric cyclic nucleotide-gated channel of Caenorhabditis elegans in cultured cells von Komatsu, Hidetoshi, Jin, Young-Ho, L'Etoile, Noelle, Mori, Ikue, Bargmann, Cornelia I, Akaike, Norio, Ohshima, Yasumi

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Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40 von Hinuma, Shuji, Itoh, Yasuaki, Kawamata, Yuji, Harada, Masataka, Kobayashi, Makoto, Fujii, Ryo, Fukusumi, Shoji, Ogi, Kazuhiro, Hosoya, Masaki, Tanaka, Yasuhiro, Uejima, Hiroshi, Tanaka, Hideyuki, Maruyama, Minoru, Satoh, Rie, Okubo, Shoichi, Kizawa, Hideki, Komatsu, Hidetoshi, Matsumura, Fumika, Noguchi, Yuko, Shinohara, Tokuyuki, Fujisawa, Yukio, Fujino, Masahiko

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Identification of a G Protein-coupled Receptor Specifically Responsive to β-Alanine von Shinohara, Tokuyuki, Harada, Masataka, Ogi, Kazuhiro, Maruyama, Minoru, Fujii, Ryo, Tanaka, Hideyuki, Fukusumi, Shoji, Komatsu, Hidetoshi, Hosoya, Masaki, Noguchi, Yuko, Watanabe, Takuya, Moriya, Takeo, Itoh, Yasuaki, Hinuma, Shuji

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Fasiglifam (TAK‐875) has dual potentiating mechanisms via Gαq‐GPR40/FFAR1 signaling branches on glucose‐dependent insulin secretion von Sakuma, Kensuke, Yabuki, Chiori, Maruyama, Minoru, Abiru, Akiko, Komatsu, Hidetoshi, Negoro, Nobuyuki, Tsujihata, Yoshiyuki, Takeuchi, Koji, Habata, Yugo, Mori, Masaaki

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Neuromodulatory Effect of Gα s - or Gα q -Coupled G-Protein-Coupled Receptor on NMDA Receptor Selectively Activates the NMDA Receptor/Ca 2+ /Calcineurin/cAMP Response Element-Bindi... von Fukuchi, Mamoru, Tabuchi, Akiko, Kuwana, Yuki, Watanabe, Shinjiro, Inoue, Minami, Takasaki, Ichiro, Izumi, Hironori, Tanaka, Ayumi, Inoue, Ran, Mori, Hisashi, Komatsu, Hidetoshi, Takemori, Hiroshi, Okuno, Hiroyuki, Bito, Haruhiko, Tsuda, Masaaki

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Neuromodulatory Effect of G alpha sub(s)- or G alpha sub(q)-Coupled G-Protein-Coupled Receptor on NMDA Receptor Selectively Activates the NMDA Receptor/Ca super(2+)/Calcineurin/cAM... von Fukuchi, Mamoru, Tabuchi, Akiko, Kuwana, Yuki, Watanabe, Shinjiro, Inoue, Minami, Takasaki, Ichiro, Izumi, Hironori, Tanaka, Ayumi, Inoue, Ran, Mori, Hisashi, Komatsu, Hidetoshi, Takemori, Hiroshi, Okuno, Hiroyuki, Bito, Haruhiko, Tsuda, Masaaki

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