SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801 von Wahl, Angela, Gralinski, Lisa E., Johnson, Claire E., Yao, Wenbo, Kovarova, Martina, Dinnon, Kenneth H., Liu, Hongwei, Madden, Victoria J., Krzystek, Halina M., De, Chandrav, White, Kristen K., Gully, Kendra, Schäfer, Alexandra, Zaman, Tanzila, Leist, Sarah R., Grant, Paul O., Bluemling, Gregory R., Kolykhalov, Alexander A., Natchus, Michael G., Askin, Frederic B., Painter, George, Browne, Edward P., Jones, Corbin D., Pickles, Raymond J., Baric, Ralph S., Garcia, J. Victor

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Efficient Initiation of HCV RNA Replication in Cell Culture von Blight, Keril J., Kolykhalov, Alexander A., Rice, Charles M.

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Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses von Yoon, Jeong-Joong, Toots, Mart, Lee, Sujin, Lee, Myung-Eun, Ludeke, Barbara, Luczo, Jasmina M, Ganti, Ketaki, Cox, Robert M, Sticher, Zachary M, Edpuganti, Vindya, Mitchell, Deborah G, Lockwood, Mark A, Kolykhalov, Alexander A, Greninger, Alexander L, Moore, Martin L, Painter, George R, Lowen, Anice C, Tompkins, Stephen M, Fearns, Rachel, Natchus, Michael G, Plemper, Richard K

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The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection von Painter, George R., Bowen, Richard A., Bluemling, Gregory R., DeBergh, John, Edpuganti, Vindhya, Gruddanti, Prabhakar R., Guthrie, David B., Hager, Michael, Kuiper, Damien L., Lockwood, Mark A., Mitchell, Deborah G., Natchus, Michael G., Sticher, Zachary M., Kolykhalov, Alexander A.

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4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses von Lieber, Carolin M, Aggarwal, Megha, Yoon, Jeong-Joong, Cox, Robert M, Kang, Hae-Ji, Sourimant, Julien, Toots, Mart, Johnson, Scott K, Jones, Cheryl A, Sticher, Zachary M, Kolykhalov, Alexander A, Saindane, Manohar T, Tompkins, Stephen M, Planz, Oliver, Painter, George R, Natchus, Michael G, Sakamoto, Kaori, Plemper, Richard K

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Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models von Cox, Robert M., Lieber, Carolin M., Wolf, Josef D., Karimi, Amirhossein, Lieberman, Nicole A. P., Sticher, Zachary M., Roychoudhury, Pavitra, Andrews, Meghan K., Krueger, Rebecca E., Natchus, Michael G., Painter, George R., Kolykhalov, Alexander A., Greninger, Alexander L., Plemper, Richard K.

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Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets von Cox, Robert M., Wolf, Josef D., Lieberman, Nicole A., Lieber, Carolin M., Kang, Hae-Ji, Sticher, Zachary M., Yoon, Jeong-Joong, Andrews, Meghan K., Govindarajan, Mugunthan, Krueger, Rebecca E., Sobolik, Elizabeth B., Natchus, Michael G., Gewirtz, Andrew T., deSwart, Rik L., Kolykhalov, Alexander A., Hekmatyar, Khan, Sakamoto, Kaori, Greninger, Alexander L., Plemper, Richard K.

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4'-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivo von Yin, Peiqi, May, Nicholas A, Lello, Laura Sandra, Fayed, Atef, Parks, M Guston, Drobish, Adam M, Wang, Sainan, Andrews, Meghan, Sticher, Zachary, Kolykhalov, Alexander A, Natchus, Michael G, Painter, George R, Merits, Andres, Kielian, Margaret, Morrison, Thomas E

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Transmission of Hepatitis C by Intrahepatic Inoculation with Transcribed RNA von Kolykhalov, Alexander A., Agapov, Eugene V., Blight, Keril J., Mihalik, Kathleen, Feinstone, Stephen M., Rice, Charles M.

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Hepatitis C Virus-Encoded Enzymatic Activities and Conserved RNA Elements in the 3′ Nontranslated Region Are Essential for Virus Replication In Vivo von Kolykhalov, A A, Mihalik, K, Feinstone, S M, Rice, C M

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Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA von Kolykhalov, A A, Feinstone, S M, Rice, C M

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Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance von Agostini, Maria L., Pruijssers, Andrea J., Chappell, James D., Gribble, Jennifer, Lu, Xiaotao, Andres, Erica L., Bluemling, Gregory R., Lockwood, Mark A., Sheahan, Timothy P., Sims, Amy C., Natchus, Michael G., Saindane, Manohar, Kolykhalov, Alexander A., Painter, George R., Baric, Ralph S., Denison, Mark R.

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Small-Molecule Antiviral β-d- N 4 -Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance von Agostini, Maria L, Pruijssers, Andrea J, Chappell, James D, Gribble, Jennifer, Lu, Xiaotao, Andres, Erica L, Bluemling, Gregory R, Lockwood, Mark A, Sheahan, Timothy P, Sims, Amy C, Natchus, Michael G, Saindane, Manohar, Kolykhalov, Alexander A, Painter, George R, Baric, Ralph S, Denison, Mark R

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4'-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication von Sourimant, Julien, Lieber, Carolin M, Aggarwal, Megha, Cox, Robert M, Wolf, Josef D, Yoon, Jeong-Joong, Toots, Mart, Ye, Chengin, Sticher, Zachary, Kolykhalov, Alexander A, Martinez-Sobrido, Luis, Bluemling, Gregory R, Natchus, Michael G, Painter, George R, Plemper, Richard K

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β-d- N 4 -Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome von Urakova, Nadya, Kuznetsova, Valeriya, Crossman, David K, Sokratian, Arpine, Guthrie, David B, Kolykhalov, Alexander A, Lockwood, Mark A, Natchus, Michael G, Crowley, Michael R, Painter, George R, Frolova, Elena I, Frolov, Ilya

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The Stability Challenge of Furanic Platform Chemicals in Acidic and Basic Conditions von Kolykhalov, Denis A, Golysheva, Anastasia N, Erokhin, Kirill S, Karlinskii, Bogdan Ya, Ananikov, Valentine P

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Analysis of Ribonucleotide 5'-Triphosphate Analogs as Potential Inhibitors of Zika Virus RNA-Dependent RNA Polymerase by Using Nonradioactive Polymerase Assays von Lu, Gaofei, Bluemling, Gregory R, Collop, Paul, Hager, Michael, Kuiper, Damien, Gurale, Bharat P, Painter, George R, De La Rosa, Abel, Kolykhalov, Alexander A

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ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens von Squires, Katherine E, Mayers, Douglas L, Bluemling, Gregory R, Kolykhalov, Alexander A, Guthrie, David B, Reddy, Prabhakar, Mitchell, Debbie G, Saindane, Manohar T, Sticher, Zachary M, Edpuganti, Vindhya, De La Rosa, Abel

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Analysis of the Potential for N 4 -Hydroxycytidine To Inhibit Mitochondrial Replication and Function von Sticher, Zachary M, Lu, Gaofei, Mitchell, Deborah G, Marlow, Joshua, Moellering, Levi, Bluemling, Gregory R, Guthrie, David B, Natchus, Michael G, Painter, George R, Kolykhalov, Alexander A

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Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine von Westover, Jonna B, Jung, Kie Hoon, Alkan, Cigdem, Boardman, Kirsten M, Van Wettere, Arnaud J, Martens, Craig, Rojas, Inioska, Hicks, Philip, Thomas, Aaron J, Saindane, Manohar T, Bluemling, Gregory R, Mao, Shuli, Kolykhalov, Alexander A, Natchus, Michael G, Bates, Paul, Painter, George R, Ikegami, Tetsuro, Gowen, Brian B

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