The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis von Van Roy, Maarten, Ververken, Cedric, Beirnaert, Els, Hoefman, Sven, Kolkman, Joost, Vierboom, Michel, Breedveld, Elia, 't Hart, Bert, Poelmans, Sofie, Bontinck, Lieselot, Hemeryck, Alex, Jacobs, Sandy, Baumeister, Judith, Ulrichts, Hans

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Structural basis for potent neutralization of human respirovirus type 3 by protective single-domain camelid antibodies von Johnson, Nicole V., van Scherpenzeel, Revina C., Bakkers, Mark J. G., Ramamohan, Ajit R., van Overveld, Daan, Le, Lam, Langedijk, Johannes P. M., Kolkman, Joost A., McLellan, Jason S.

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Nanobodies targeting the hepatocyte growth factor: potential new drugs for molecular cancer therapy von Vosjan, Maria J W D, Vercammen, Jo, Kolkman, Joost A, Stigter-van Walsum, Marijke, Revets, Hilde, van Dongen, Guus A M S

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A neutralizing single-domain antibody that targets the trimer interface of the human metapneumovirus fusion protein von Ballegeer, Marlies, van Scherpenzeel, Revina C, Delgado, Teresa, Iglesias-Caballero, Maria, García Barreno, Blanca, Pandey, Shubham, Rush, Scott A, Kolkman, Joost A, Mas, Vicente, McLellan, Jason S, Saelens, Xavier

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Directed evolution of proteins by exon shuffling von Stemmer, Willem P.C, Kolkman, Joost A

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Multivalent nanobodies targeting death receptor 5 elicit superior tumor cell killing through efficient caspase induction von Huet, Heather A, Growney, Joseph D, Johnson, Jennifer A, Li, Jing, Bilic, Sanela, Ostrom, Lance, Zafari, Mohammad, Kowal, Colleen, Yang, Guizhi, Royo, Axelle, Jensen, Michael, Dombrecht, Bruno, Meerschaert, Kris R A, Kolkman, Joost A, Cromie, Karen D, Mosher, Rebecca, Gao, Hui, Schuller, Alwin, Isaacs, Randi, Sellers, William R, Ettenberg, Seth A

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Nanobodies – from llamas to therapeutic proteins von Kolkman, Joost A., Law, Debbie A.

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Insertion Loop 256−268 in Coagulation Factor IX Restricts Enzymatic Activity in the Absence but Not in the Presence of Factor VIII von Kolkman, Joost A, Mertens, Koen

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A neutralizing single-domain antibody that targets the trimer interface of the human metapneumovirus fusion protein von Ballegeer, Marlies, van Scherpenzeel, Revina C, Delgado, Teresa, Iglesias-Caballero, Maria, García Barreno, Blanca, Pandey, Shubham, Rush, Scott A, Kolkman, Joost A, Mas, Vicente, McLellan, Jason S, Saelens, Xavier

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Molecular evolution of mammalian ribonucleases 1 von Dubois, Jean-Yves F, Ursing, Björn M, Kolkman, Joost A, Beintema, Jaap J

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Residues Phe342-Asn346 of activated coagulation factor IX contribute to the interaction with low density lipoprotein receptor-related protein von Rohlena, Jakub, Kolkman, Joost A, Boertjes, Ria C, Mertens, Koen, Lenting, Peter J

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Universal Protection against Influenza Infection by a Multi-Domain Antibody to Influenza Hemagglutinin von Laursen, Nick S., Friesen, Robert H. E., Zhu, Xueyong, Jongeneelen, Mandy, Blokland, Sven, Vermond, Jan, van Eijgen, Alida, Tang, Chan, van Diepen, Harry, Oblomova, Galina, van der Neut Kolfschoten, Marijn, Zuijdgeest, David, Straetemans, Roel, Hoffman, Ryan M. B., Nieusma, Travis, Pallesen, Jesper, Turner, Hannah L., Bernard, Steffen M., Ward, Andrew B., Luo, Jinquan, Poon, Leo L. M., Tretiakova, Anna P., Wilson, James M., Limberis, Maria P., Vogels, Ronald, Brandenburg, Boerries, Kolkman, Joost A., Wilson, Ian A.

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Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin von Laursen, Nick S, Friesen, Robert H E, Zhu, Xueyong, Jongeneelen, Mandy, Blokland, Sven, Vermond, Jan, van Eijgen, Alida, Tang, Chan, van Diepen, Harry, Obmolova, Galina, van der Neut Kolfschoten, Marijn, Zuijdgeest, David, Straetemans, Roel, Hoffman, Ryan M B, Nieusma, Travis, Pallesen, Jesper, Turner, Hannah L, Bernard, Steffen M, Ward, Andrew B, Luo, Jinquan, Poon, Leo L M, Tretiakova, Anna P, Wilson, James M, Limberis, Maria P, Vogels, Ronald, Brandenburg, Boerries, Kolkman, Joost A, Wilson, Ian A

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Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains von Silverman, Joshua, Stemmer, Willem Pim C, Lu, Qiang, Bakker, Alice, To, Wayne, Duguay, Amy, Alba, Ben M, Smith, Richard, Rivas, Alberto, Li, Peng, Le, Hon, Whitehorn, Erik, Moore, Kevin W, Swimmer, Candace, Perlroth, Victor, Vogt, Martin, Kolkman, Joost

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Regions 301–303 and 333–339 in the catalytic domain of blood coagulation Factor IX are Factor VIII-interactive sites involved in stimulation of enzyme activity von KOLKMAN, Joost A., LENTING, Peter J., MERTENS, Koen

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Regions 301-303 and 333-339 in the catalytic domain of blood coagulation factor IX are factor VIII-interactive sites involved in stimulation of enzyme activity von Kolkman, J A, Lenting, P J, Mertens, K

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Surface-loop residue Lys316 in blood coagulation Factor IX is a major determinant for Factor X but not antithrombin recognition von KOLKMAN, Joost A., MERTENS, Koen

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Providing improved immunoglobulin sequences by mutating CDR and/or FR positions von Kolkman, Joost Alexander

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METHODS FOR PROVIDING IMPROVED IMMUNOGLOBULIN SEQUENCES von KOLKMAN, JOOST ALEXANDER

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Blood Coagulation Factor IX Residues Glu78 and Arg94 Provide a Link between Both Epidermal Growth Factor-like Domains That Is Crucial in the Interaction with Factor VIII Light Chai... von Christophe, Olivier D., Lenting, Peter J., Kolkman, Joost A., Brownlee, George G., Mertens, Koen

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