Development of Specific PET Tracers for Central Nervous System Drug Targets von Koike, Tatsuki

Volltext

Orexin receptor 2 agonist activates diaphragm and genioglossus muscle through stimulating inspiratory neurons in the pre-Bötzinger complex, and phrenic and hypoglossal motoneurons... von Yamada, Ryuji, Koike, Tatsuki, Nakakariya, Masanori, Kimura, Haruhide

Volltext

Effects of an OX2R agonist on migration and removal of tau from mouse brain von Terada, Michiko, Mitsukawa, Kayo, Nakakariya, Masanori, Koike, Tatsuki, Kimura, Haruhide

Volltext

Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors von Aida, Jumpei, Fushimi, Makoto, Kusumoto, Tomokazu, Sugiyama, Hideyuki, Arimura, Naoto, Ikeda, Shuhei, Sasaki, Masako, Sogabe, Satoshi, Aoyama, Kazunobu, Koike, Tatsuki

Volltext

Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H) von Koike, Tatsuki, Yoshikawa, Masato, Ando, Haruhi Kamisaki, Farnaby, William, Nishi, Toshiya, Watanabe, Etsurou, Yano, Jason, Miyamoto, Maki, Kondo, Shigeru, Ishii, Tsuyoshi, Kuroita, Takanobu

Volltext

TAK-861, a potent, orally available orexin receptor 2-selective agonist, produces wakefulness in monkeys and improves narcolepsy-like phenotypes in mouse models von Mitsukawa, Kayo, Terada, Michiko, Yamada, Ryuji, Monjo, Taku, Hiyoshi, Tetsuaki, Nakakariya, Masanori, Kajita, Yuichi, Ando, Tatsuya, Koike, Tatsuki, Kimura, Haruhide

Volltext

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice von Nishi, Toshiya, Kondo, Shinichi, Miyamoto, Maki, Watanabe, Sayuri, Hasegawa, Shigeo, Kondo, Shigeru, Yano, Jason, Watanabe, Etsurou, Ishi, Tsuyoshi, Yoshikawa, Masato, Ando, Haruhi Kamisaki, Farnaby, William, Fujimoto, Shinji, Sunahara, Eiji, Ohori, Momoko, During, Matthew J., Kuroita, Takanobu, Koike, Tatsuki

Volltext

Discovery of a Novel and Brain-Penetrant O‑GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization von Tawada, Michiko, Fushimi, Makoto, Masuda, Kei, Sun, Huikai, Uchiyama, Noriko, Kosugi, Yohei, Lane, Weston, Tjhen, Richard, Endo, Satoshi, Koike, Tatsuki

Volltext

Molecular mechanism of the wake-promoting agent TAK-925 von Yin, Jie, Kang, Yanyong, McGrath, Aaron P., Chapman, Karen, Sjodt, Megan, Kimura, Eiji, Okabe, Atsutoshi, Koike, Tatsuki, Miyanohana, Yuhei, Shimizu, Yuji, Rallabandi, Rameshu, Lian, Peng, Bai, Xiaochen, Flinspach, Mack, De Brabander, Jef K., Rosenbaum, Daniel M.

Volltext

Design, Synthesis, and Evaluation of (4R)‑1-{3-[2‑(18F)Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one ([18F]T‑401) as a Novel Po... von Hattori, Yasushi, Aoyama, Kazunobu, Maeda, Jun, Arimura, Naoto, Takahashi, Yasuko, Sasaki, Masako, Fujinaga, Masayuki, Seki, Chie, Nagai, Yuji, Kawamura, Kazunori, Yamasaki, Tomoteru, Zhang, Ming-Rong, Higuchi, Makoto, Koike, Tatsuki

Volltext

Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors von Kajita, Yuichi, Ikeda, Shuhei, Yoshikawa, Masato, Fukuda, Hiromi, Watanabe, Etsurou, Yano, Jason, Lane, Weston, Miyamoto, Maki, Ishii, Tsuyoshi, Nishi, Toshiya, Koike, Tatsuki

Volltext

Design, Synthesis, and Evaluation of (2-Aminocyclopropyl)phenyl Derivatives as Novel Positron Emission Tomography Imaging Agents for Lysine-Specific Demethylase 1 in the Brain von Hattori, Yasushi, Matsuda, Satoru, Baba, Rina, Matsumiya, Kouta, Iwasaki, Shinji, Constantinescu, Cristian C, Morley, Thomas J, Carroll, Vincent M, Papin, Caroline, Gouasmat, Alexandra, Alagille, David, Tamagnan, Gilles, Koike, Tatsuki

Volltext

Preclinical characterization of [18F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase von Koike, Tatsuki, Constantinescu, Cristian C., Ikeda, Shuhei, Nishi, Toshiya, Sunahara, Eiji, Miyamoto, Maki, Cole, Patricia, Barret, Olivier, Alagille, David, Papin, Caroline, Morley, Thomas, Fowles, Krista, Seibyl, John, Tamagnan, Gilles, Kuroita, Takanobu

Volltext

Reply to: The G protein preference of orexin receptors is currently an unresolved issue von Yin, Jie, Kang, Yanyong, McGrath, Aaron P., Chapman, Karen, Sjodt, Megan, Kimura, Eiji, Okabe, Atsutoshi, Koike, Tatsuki, Miyanohana, Yuhei, Shimizu, Yuji, Rallabandi, Rameshu, Lian, Peng, Bai, Xiaochen, Flinspach, Mack, De Brabander, Jef K., Rosenbaum, Daniel M.

Volltext

Design and synthesis of aryl-piperidine derivatives as potent and selective PET tracers for cholesterol 24-hydroxylase (CH24H) von Ikeda, Shuhei, Kajita, Yuichi, Miyamoto, Maki, Matsumiya, Kouta, Ishii, Tsuyoshi, Nishi, Toshiya, Gay, Sean C., Lane, Weston, Constantinescu, Cristian C., Alagille, David, Papin, Caroline, Tamagnan, Gilles, Kuroita, Takanobu, Koike, Tatsuki

Volltext

Design, Synthesis, and Evaluation of 11C‑Labeled 3‑Acetyl-Indole Derivatives as a Novel Positron Emission Tomography Imaging Agent for Diacylglycerol Kinase Gamma (DGKγ) in Brain... von Hattori, Yasushi, Yamasaki, Tomoteru, Ohashi, Tomohiro, Miyanohana, Yuhei, Kusumoto, Tomokazu, Maeda, Ryouta, Miyamoto, Maki, Debori, Yasuyuki, Hata, Akito, Zhang, Yiding, Wakizaka, Hidekatsu, Wakabayashi, Takeshi, Fujinaga, Masayuki, Yamashita, Ryo, Zhang, Ming-Rong, Koike, Tatsuki

Volltext

Deep learning for hetero–homo conversion in channel-domain for phase aberration correction in ultrasound imaging von Koike, Tatsuki, Tomii, Naoki, Watanabe, Yoshiki, Azuma, Takashi, Takagi, Shu

Volltext

TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcol... von Ishikawa, Takashi, Hara, Hiroe, Kawano, Ayumi, Tohyama, Kimio, Kajita, Yuichi, Miyanohana, Yuhei, Koike, Tatsuki, Kimura, Haruhide

Volltext

Synthesis of Low-Molecular-Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS-CoV-2 Infection von Sugimoto, Aoi, Koike, Tatsuki, Kuboki, Yuya, Komaba, Sumika, Kosono, Shuhei, Aswathy, Maniyamma, Anzai, Itsuki, Watanabe, Tokiko, Toshima, Kazunobu, Takahashi, Daisuke

Volltext

Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist von Hoashi, Yasutaka, Takai, Takafumi, Kosugi, Yohei, Nakashima, Masato, Nakayama, Masaharu, Hirai, Keisuke, Uchikawa, Osamu, Koike, Tatsuki

Volltext