The Selective Oral Immunomodulator Vidofludimus in Patients with Active Rheumatoid Arthritis: Safety Results from the COMPONENT Study von Muehler, Andreas, Kohlhof, Hella, Groeppel, Manfred, Vitt, Daniel

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Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner von Mishra, Vivek Kumar, Wegwitz, Florian, Kosinsky, Robyn Laura, Sen, Madhobi, Baumgartner, Roland, Wulff, Tanja, Siveke, Jens T, Schildhaus, Hans-Ulrich, Najafova, Zeynab, Kari, Vijayalakshmi, Kohlhof, Hella, Hessmann, Elisabeth, Johnsen, Steven A

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Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC‐202 blocks oncogenic hedgehog‐GLI signaling and overcomes smoothened inhibitor resistance von Gruber, Wolfgang, Peer, Elisabeth, Elmer, Dominik P., Sternberg, Christina, Tesanovic, Suzana, del Burgo, Pedro, Coni, Sonia, Canettieri, Gianluca, Neureiter, Daniel, Bartz, René, Kohlhof, Hella, Vitt, Daniel, Aberger, Fritz

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IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro von Hahn, Friedrich, Wangen, Christina, Häge, Sigrun, Peter, Antonia Sophia, Dobler, Gerhard, Hurst, Brett, Julander, Justin, Fuchs, Jonas, Ruzsics, Zsolt, Überla, Klaus, Jäck, Hans-Martin, Ptak, Roger, Muehler, Andreas, Gröppel, Manfred, Vitt, Daniel, Peelen, Evelyn, Kohlhof, Hella, Marschall, Manfred

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Evaluation of the Therapeutic Potential of the Novel Isotype Specific HDAC Inhibitor 4SC-202 in Urothelial Carcinoma Cell Lines von Pinkerneil, Maria, Hoffmann, Michèle J., Kohlhof, Hella, Schulz, Wolfgang A., Niegisch, Günter

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Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells von Wobser, Marion, Weber, Alexandra, Glunz, Amelie, Tauch, Saskia, Seitz, Kristina, Butelmann, Tobias, Hesbacher, Sonja, Goebeler, Matthias, Bartz, René, Kohlhof, Hella, Schrama, David, Houben, Roland

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Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro von Kim, Yu-Jin, Cubitt, Beatrice, Cai, Yingyun, Kuhn, Jens H, Vitt, Daniel, Kohlhof, Hella, de la Torre, Juan C

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Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication von Stegmann, Kim M., Dickmanns, Antje, Heinen, Natalie, Blaurock, Claudia, Karrasch, Tim, Breithaupt, Angele, Klopfleisch, Robert, Uhlig, Nadja, Eberlein, Valentina, Issmail, Leila, Herrmann, Simon T., Schreieck, Amelie, Peelen, Evelyn, Kohlhof, Hella, Sadeghi, Balal, Riek, Alexander, Speakman, John R., Groß, Uwe, Görlich, Dirk, Vitt, Daniel, Müller, Thorsten, Grunwald, Thomas, Pfaender, Stephanie, Balkema-Buschmann, Anne, Dobbelstein, Matthias

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Methodological Development of a Multi-Readout Assay for the Assessment of Antiviral Drugs against SARS-CoV-2 von Hahn, Friedrich, Häge, Sigrun, Herrmann, Alexandra, Wangen, Christina, Kicuntod, Jintawee, Jungnickl, Doris, Tillmanns, Julia, Müller, Regina, Fraedrich, Kirsten, Überla, Klaus, Kohlhof, Hella, Ensser, Armin, Marschall, Manfred

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A novel microtubule inhibitor 4SC-207 with anti-proliferative activity in taxane-resistant cells von Bausch, Elena, Kohlhof, Hella, Hamm, Svetlana, Krauss, Rolf, Baumgartner, Roland, Sironi, Lucia

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Notch Signaling Induces Multilineage Myeloid Differentiation and Up-Regulates PU.1 Expression von Schroeder, Timm, Kohlhof, Hella, Rieber, Nikolaus, Just, Ursula

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4SC-202 as a Potential Treatment for the Pediatric Brain Tumor Medulloblastoma von Messerli, Shanta M, Hoffman, Mariah M, Gnimpieba, Etienne Z, Kohlhof, Hella, Bhardwaj, Ratan D

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RPPApipe: A pipeline for the analysis of reverse-phase protein array data von Eichner, Johannes, Heubach, Yvonne, Ruff, Manuel, Kohlhof, Hella, Strobl, Stefan, Mayer, Barbara, Pawlak, Michael, Templin, Markus F., Zell, Andreas

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Molecular analysis of the 2022 mpox outbreak and antiviral activity of dihydroorotate dehydrogenase inhibitors against orthopoxviruses von Cordsmeier, Arne, Herrmann, Alexandra, Gege, Christian, Kohlhof, Hella, Korn, Klaus, Ensser, Armin

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788 FIRST IN HUMAN TRIAL OF IMU-856, AN ORALLY AVAILABLE EPIGENETIC MODULATOR OF BARRIER REGENERATION FOR THE TREATMENT OF CELIAC DISEASE von Buriánek, Franziska, Pröbstl, Doris, Peelen, Evelyn, Fonseca, Juliano, Schreieck, Amelie, Wirth, Martina, Kehler, Inge, Vitt, Daniel, Kohlhof, Hella, Muehler, Andreas

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Safety, Tolerability and Pharmacokinetics of Vidofludimus calcium (IMU-838) After Single and Multiple Ascending Oral Doses in Healthy Male Subjects von Muehler, Andreas, Kohlhof, Hella, Groeppel, Manfred, Vitt, Daniel

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Validation of nuclear receptor RORγ isoform 1 as a novel host-directed antiviral target based on the modulation of cholesterol levels von Wangen, Christina, Raithel, Andrea, Tillmanns, Julia, Gege, Christian, Herrmann, Alexandra, Vitt, Daniel, Kohlhof, Hella, Marschall, Manfred, Hahn, Friedrich

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EP63 FIRST IN HUMAN TRIAL OF IMU-856, AN ORALLY AVAILABLE REGULATOR OF BARRIER FUNCTION FOR THE TREATMENT OF CELIAC DISEASE von Buriánek, Franziska, Polasek, Thomas, Mihajlovic, Jelena, Peelen, Evelyn, Fonseca, Juliano, Wirth, Martina, Kehler, Inge, Vitt, Daniel, Kohlhof, Hella, Muehler, Andreas

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Development of a Potent Nurr1 Agonist Tool for In Vivo Applications von Vietor, Jan, Gege, Christian, Stiller, Tanja, Busch, Romy, Schallmayer, Espen, Kohlhof, Hella, Höfner, Georg, Pabel, Jörg, Marschner, Julian A., Merk, Daniel

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Vidofludimus calcium, a next generation DHODH inhibitor for the Treatment of relapsing-remitting multiple sclerosis von Muehler, Andreas, Peelen, Evelyn, Kohlhof, Hella, Gröppel, Manfred, Vitt, Daniel

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