Managing the sequence-specificity of antisense oligonucleotides in drug discovery von Hagedorn, Peter H, Hansen, Bo R, Koch, Troels, Lindow, Morten

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Locked nucleic acid: modality, diversity, and drug discovery von Hagedorn, Peter H., Persson, Robert, Funder, Erik D., Albæk, Nanna, Diemer, Sanna L., Hansen, Dennis J., Møller, Marianne R., Papargyri, Natalia, Christiansen, Helle, Hansen, Bo R., Hansen, Henrik F., Jensen, Mads A., Koch, Troels

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Silencing of microRNA families by seed-targeting tiny LNAs von Obad, Susanna, dos Santos, Camila O, Petri, Andreas, Heidenblad, Markus, Broom, Oliver, Ruse, Cristian, Fu, Cexiong, Lindow, Morten, Stenvang, Jan, Straarup, Ellen Marie, Hansen, Henrik Frydenlund, Koch, Troels, Pappin, Darryl, Hannon, Gregory J, Kauppinen, Sakari

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Refining LNA safety profile by controlling phosphorothioate stereochemistry von Funder, Erik Daa, Albæk, Nanna, Moisan, Annie, Sewing, Sabine, Koch, Troels

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Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents von Stein, C.A, Hansen, J. Bo, Lai, Johnathan, Wu, SiJian, Voskresenskiy, Anatoliy, Høg, Anja, Worm, Jesper, Hedtjärn, Maj, Souleimanian, Naira, Miller, Paul, Soifer, Harris S, Castanotto, Daniella, Benimetskaya, Luba, Ørum, Henrik, Koch, Troels

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A cytoplasmic pathway for gapmer antisense oligonucleotide-mediated gene silencing in mammalian cells von Castanotto, Daniela, Lin, Min, Kowolik, Claudia, Wang, LiAnn, Ren, Xiao-Qin, Soifer, Harris S, Koch, Troels, Hansen, Bo Rode, Oerum, Henrik, Armstrong, Brian, Wang, Zhigang, Bauer, Paul, Rossi, John, Stein, C A

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In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3' and 5' thiophosphate linkages von Duschmalé, Jörg, Hansen, Henrik Frydenlund, Duschmalé, Martina, Koller, Erich, Albaek, Nanna, Møller, Marianne Ravn, Jensen, Klaus, Koch, Troels, Wengel, Jesper, Bleicher, Konrad

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Chemical Diversity of Locked Nucleic Acid-Modified Antisense Oligonucleotides Allows Optimization of Pharmaceutical Properties von Papargyri, Natalia, Pontoppidan, Malene, Andersen, Mikael R., Koch, Troels, Hagedorn, Peter H.

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In vivo uptake of antisense oligonucleotide drugs predicted by ab initio quantum mechanical calculations von Hansen, Henrik Frydenlund, Albaek, Nanna, Hansen, Bo Rode, Shim, Irene, Bohr, Henrik, Koch, Troels

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Silencing of Gene Expression by Gymnotic Delivery of Antisense Oligonucleotides von Soifer, Harris S., Koch, Troels, Lai, Johnathan, Hansen, Bo, Hoeg, Anja, Oerum, Henrik, Stein, C. A.

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Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe von Lamers, Fieke, van der Ploeg, Ida, Schild, Linda, Ebus, Marli E, Koster, Jan, Hansen, Bo R, Koch, Troels, Versteeg, Rogier, Caron, Huib N, Molenaar, Jan J

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Electronic Structures of LNA Phosphorothioate Oligonucleotides von Bohr, Henrik G., Shim, Irene, Stein, Cy, Ørum, Henrik, Hansen, Henrik F., Koch, Troels

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A Multifunctional LNA Oligonucleotide-Based Strategy Blocks AR Expression and Transactivation Activity in PCa Cells von Castanotto, Daniela, Zhang, Xiaowei, Rüger, Jacqueline, Alluin, Jessica, Sharma, Ritin, Pirrotte, Patrick, Joenson, Lars, Ioannou, Silvia, Nelson, Michael S., Vikeså, Jonas, Hansen, Bo Rode, Koch, Troels, Jensen, Mads Aaboe, Rossi, John J., Stein, Cy A.

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Investigating discovery strategies and pharmacological properties of stereodefined phosphorodithioate LNA gapmers von Duschmalé, Jörg, Schäublin, Adrian, Funder, Erik, Schmidt, Steffen, Kiełpiński, Łukasz J., Nymark, Helle, Jensen, Klaus, Koch, Troels, Duschmalé, Martina, Koller, Erich, Møller, Marianne Ravn, Schadt, Simone, Husser, Christophe, Brink, Andreas, Sewing, Sabine, Minz, Tanja, Wengel, Jesper, Bleicher, Konrad, Li, Meiling

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SPC3042: a proapoptotic survivin inhibitor von Hansen, Jens Bo, Fisker, Niels, Westergaard, Majken, Kjaerulff, Lene Sønderby, Hansen, Henrik Frydenlund, Thrue, Charlotte Albaek, Rosenbohm, Christoph, Wissenbach, Margit, Orum, Henrik, Koch, Troels

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The synergism of MCL1 and glycolysis on pediatric acute lymphoblastic leukemia cell survival and prednisolone resistance von Ariës, Ingrid M, Hansen, Bo R, Koch, Troels, van den Dungen, Rosanna, Evans, William E, Pieters, Rob, den Boer, Monique L

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Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides von Anderson, Brian R., Jensen, Marianne L., Hagedorn, Peter H., Little, Sean C., Olson, Richard E., Ammar, Ron, Kienzle, Bernadette, Thompson, John, McDonald, Ivar, Mercer, Stephen, Vikesaa, Jonas, Nordbo, Bettina, Iben, Larry, Cao, Yang, Natale, Joanne, Dalton-Kay, Greg, Cacace, Angela, Hansen, Bo R., Hedtjärn, Maj, Koch, Troels, Bristow, Linda J.

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Photochemical Immobilization of Anthraquinone Conjugated Oligonucleotides and PCR Amplicons on Solid Surfaces von Koch, Troels, Jacobsen, Nana, Fensholdt, Jef, Boas, Ulrich, Fenger, Mogens, Jakobsen, Mogens H

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Stopped-flow kinetics of locked nucleic acid (LNA)-oligonucleotide duplex formation: studies of LNA-DNA and DNA-DNA interactions von Christensen, U, Jacobsen, N, Rajwanshi, V K, Wengel, J, Koch, T

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Identifying Suitable Target Regions and Analyzing Off-Target Effects of Therapeutic Oligonucleotides von Pedersen, Lykke, Hagedorn, Peter H., Koch, Troels

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