Large-Scale Adeno-Associated Viral Vector Production Using a Herpesvirus-Based System Enables Manufacturing for Clinical Studies von CLEMENT, Nathalie, KNOP, David R, BYRNE, Barry J

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Safety and Biodistribution Evaluation in Cynomolgus Macaques of rAAV2tYF-CB-hRS1, a Recombinant Adeno-Associated Virus Vector Expressing Retinoschisin von Ye, Guo-Jie, Budzynski, Ewa, Sonnentag, Peter, Miller, Paul E, Sharma, Alok K, Ver Hoeve, James N, Howard, Kellie, Knop, David R, Neuringer, Martha, McGill, Trevor, Stoddard, Jonathan, Chulay, Jeffrey D

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Ocular Inflammatory Response to Intravitreal Injection of Adeno-Associated Virus Vector: Relative Contribution of Genome and Capsid von Timmers, Adrian M., Newmark, Judith A., Turunen, Heikki T., Farivar, Tanaz, Liu, Jilin, Song, Chunjuan, Ye, Guo-Jie, Pennock, Steven, Gaskin, Chantelle, Knop, David R., Shearman, Mark S.

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Hydroaromatic Equilibration During Biosynthesis of Shikimic Acid von Knop, David R, Draths, K. M, Chandran, Sunil S, Barker, Jessica L, von Daeniken, Ralph, Weber, Wolfgang, Frost, J. W

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Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression von Mueller, Christian, Chulay, Jeffrey D, Trapnell, Bruce C, Humphries, Margaret, Carey, Brenna, Sandhaus, Robert A, McElvaney, Noel G, Messina, Louis, Tang, Qiushi, Rouhani, Farshid N, Campbell-Thompson, Martha, Fu, Ann Dongtao, Yachnis, Anthony, Knop, David R, Ye, Guo-Jie, Brantly, Mark, Calcedo, Roberto, Somanathan, Suryanarayan, Richman, Lee P, Vonderheide, Robert H, Hulme, Maigan A, Brusko, Todd M, Wilson, James M, Flotte, Terence R

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Dose Range Finding Studies with Two RPGR Transgenes in a Canine Model of X-Linked Retinitis Pigmentosa Treated with Subretinal Gene Therapy von Song, Chunjuan, Dufour, Valerie L., Cideciyan, Artur V., Ye, Guo-Jie, Swider, Malgorzata, Newmark, Judith A., Timmers, Adrian M., Robinson, Paulette M., Knop, David R., Chulay, Jeffrey D., Jacobson, Samuel G., Aguirre, Gustavo D., Beltran, William A., Shearman, Mark S.

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Toxicity and Efficacy Evaluation of an Adeno-Associated Virus Vector Expressing Codon-Optimized RPGR Delivered by Subretinal Injection in a Canine Model of X-linked Retinitis Pigme... von Dufour, Valerie L., Cideciyan, Artur V., Ye, Guo-jie, Song, Chunjuan, Timmers, Adrian, Habecker, Perry L., Pan, Wei, Weinstein, Nicole M., Swider, Malgorzata, Durham, Amy C., Ying, Gui-Shuang, Robinson, Paulette M., Jacobson, Samuel G., Knop, David R., Chulay, Jeffrey D., Shearman, Mark S., Aguirre, Gustavo D., Beltran, William A.

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Phase 2 Clinical Trial of a Recombinant Adeno-Associated Viral Vector Expressing α1-Antitrypsin: Interim Results von FLOTTE, Terence R, TRAPNELL, Bruce C, MUELLER, Christian, MESSINA, Louis M, WILSON, James M, BRANTLY, Mark, KNOP, David R, YE, Guo-Jie, CHULAY, Jeffrey D, HUMPHRIES, Margaret, CAREY, Brenna, CALCEDO, Roberto, ROUHANI, Farshid, CAMPBELL-THOMPSON, Martha, YACHNIS, Anthony T, SANDHAUS, Robert A, MCELVANEY, Noel G

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Scalable Recombinant Adeno-Associated Virus Production Using Recombinant Herpes Simplex Virus Type 1 Coinfection of Suspension-Adapted Mammalian Cells von THOMAS, Darby L, WANT, Lijun, NIAMKE, Justine, JILIN LIU, WEN KANG, SCOTTI, Marina M, YE, Guo-Jie, VERES, Gabor, KNOP, David R

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Preclinical Evaluation of a Recombinant Adeno-Associated Virus Vector Expressing Human Alpha-1 Antitrypsin Made Using a Recombinant Herpes Simplex Virus Production Method von CHULAY, Jeffrey D, YE, Guo-Jie, THOMAS, Darby L, KNOP, David R, BENSON, Janet M, HUTT, Julie A, GENSHENG WANG, HUMPHRIES, Margaret, FLOTTE, Terence R

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Safety and Efficacy Evaluation of rAAV2tYF-PR1.7-hCNGA3 Vector Delivered by Subretinal Injection in CNGA3 Mutant Achromatopsia Sheep von Gootwine, Elisha, Ofri, Ron, Banin, Eyal, Obolensky, Alexey, Averbukh, Edward, Ezra-Elia, Raaya, Ross, Maya, Honig, Hen, Rosov, Alexander, Yamin, Esther, Ye, Guo-Jie, Knop, David R, Robinson, Paulette M, Chulay, Jeffrey D, Shearman, Mark S

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Safety and Biodistribution Evaluation in Cynomolgus Macaques of rAAV2tYF-PR1.7-hCNGB3, a Recombinant AAV Vector for Treatment of Achromatopsia von Ye, Guo-jie, Budzynski, Ewa, Sonnentag, Peter, Nork, T Michael, Miller, Paul E, Sharma, Alok K, Ver Hoeve, James N, Smith, Leia M, Arndt, Tara, Calcedo, Roberto, Gaskin, Chantelle, Robinson, Paulette M, Knop, David R, Hauswirth, William W, Chulay, Jeffrey D

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Safety and Biodistribution Evaluation in CNGB3-Deficient Mice of rAAV2tYF-PR1.7-hCNGB3, a Recombinant AAV Vector for Treatment of Achromatopsia von Ye, Guo-jie, Budzynski, Ewa, Sonnentag, Peter, Nork, T Michael, Miller, Paul E, McPherson, Leslie, Ver Hoeve, James N, Smith, Leia M, Arndt, Tara, Mandapati, Savitri, Robinson, Paulette M, Calcedo, Roberto, Knop, David R, Hauswirth, William W, Chulay, Jeffrey D

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Safety and Biodistribution Evaluation of rAAV2tYF-CB-hRS1, a Recombinant Adeno-Associated Virus Vector Expressing Retinoschisin, in RS1-Deficient Mice von Ye, Guo-Jie, Conlon, Thomas, Erger, Kirsten, Sonnentag, Peter, Sharma, Alok K, Howard, Kellie, Knop, David R, Chulay, Jeffrey D

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Toxicology and Pharmacology of an AAV Vector Expressing Codon-Optimized RPGR in RPGR-Deficient Rd9 Mice von Song, Chunjuan, Conlon, Thomas J, Deng, Wen-Tao, Coleman, Kirsten E, Zhu, Ping, Plummer, Cayrn, Mandapati, Savitri, Van Hoosear, Mailin, Green, Kari B, Sonnentag, Peter, Sharma, Alok K, Timmers, Adrian, Robinson, Paulette M, Knop, David R, Hauswirth, William W, Chulay, Jeffrey D, Shearman, Mark S, Ye, Guo-Jie

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Bioreactor Production of Recombinant Herpes Simplex Virus Vectors von Knop, David R., Harrell, Heather

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Shikimic Acid and Quinic Acid:  Replacing Isolation from Plant Sources with Recombinant Microbial Biocatalysis von Draths, K. M, Knop, David R, Frost, J. W

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Benzene-Free Synthesis of Hydroquinone von Ran, Ningqing, Knop, David R, Draths, K. M, Frost, J. W

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Herpes simplex virus clearance during purification of a recombinant adeno-associated virus serotype 1 vector von Ye, Guo-jie, Scotti, Marina M, Thomas, Darby L, Wang, Lijun, Knop, David R, Chulay, Jeffrey D

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Herpes Simplex Virus Clearance during Purification of a Recombinant Adeno-associated Virus Serotype 1 Vector von Ye, Guo-Jie, Scotti, Marina M, Thomas, Darby L, Wang, Lijun, Knop, David R, Chulay, Jeffrey David

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