High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein von Klumpp, Klaus, Lam, Angela M., Lukacs, Christine, Vogel, Robert, Ren, Suping, Espiritu, Christine, Baydo, Ruth, Atkins, Kateri, Abendroth, Jan, Liao, Guochun, Efimov, Andrey, Hartman, George, Flores, Osvaldo A.

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In Vivo Emergence of a Novel Mutant L159F/L320F in the NS5B Polymerase Confers Low-Level Resistance to the HCV Polymerase Inhibitors Mericitabine and Sofosbuvir von Tong, Xiao, Le Pogam, Sophie, Li, Lewyn, Haines, Kristin, Piso, Katherine, Baronas, Victoria, Yan, Jun-Mei, So, Sung-Sau, Klumpp, Klaus, Nájera, Isabel

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Assembly, Purification, and Pre-steady-state Kinetic Analysis of Active RNA-dependent RNA Polymerase Elongation Complex von Jin, Zhinan, Leveque, Vincent, Ma, Han, Johnson, Kenneth A., Klumpp, Klaus

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Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage von Datta, Kausiki, Wolkerstorfer, Andrea, Szolar, Oliver H J, Cusack, Stephen, Klumpp, Klaus

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NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase von Jin, Zhinan, Leveque, Vincent, Ma, Han, Johnson, Kenneth A, Klumpp, Klaus

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Determination of neuraminidase kinetic constants using whole influenza virus preparations and correction for spectroscopic interference by a fluorogenic substrate von Marathe, Bindumadhav M, Lévêque, Vincent, Klumpp, Klaus, Webster, Robert G, Govorkova, Elena A

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Transcriptomic analysis of the woodchuck model of chronic hepatitis B von Fletcher, Simon P., Chin, Daniel J., Ji, Yongmei, Iniguez, A. Leonardo, Taillon, Bruce, Swinney, David C., Ravindran, Palanikumar, Cheng, Donavan T., Bitter, Hans, Lopatin, Uri, Ma, Han, Klumpp, Klaus, Menne, Stephan

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Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479 von ALI, Samir, LEVEQUE, Vincent, KLUMPP, Klaus, SYMONS, Julian, CAMMACK, Nick, JIANG, Wen-Rong, LE POGAM, Sophie, HAN MA, PHILIPP, Friederike, INOCENCIO, Nicole, SMITH, Mark, ALKER, Andre, KANG, Hyunsoon, NAJERA, Isabel

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The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture von Klumpp, Klaus, Lévêque, Vincent, Le Pogam, Sophie, Ma, Han, Jiang, Wen-Rong, Kang, Hyunsoon, Granycome, Caroline, Singer, Margaret, Laxton, Carl, Hang, Julie Qi, Sarma, Keshab, Smith, David B., Heindl, Dieter, Hobbs, Chris J., Merrett, John H., Symons, Julian, Cammack, Nick, Martin, Joseph A., Devos, Rene, Nájera, Isabel

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H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load von Boon, Adrianus C M, Finkelstein, David, Zheng, Ming, Liao, Guochun, Allard, John, Klumpp, Klaus, Webster, Robert, Peltz, Gary, Webby, Richard J

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A Serine Palmitoyltransferase Inhibitor Blocks Hepatitis C Virus Replication in Human Hepatocytes von Katsume, Asao, Tokunaga, Yuko, Hirata, Yuichi, Munakata, Tsubasa, Saito, Makoto, Hayashi, Hitohisa, Okamoto, Koichi, Ohmori, Yusuke, Kusanagi, Isamu, Fujiwara, Shinya, Tsukuda, Takuo, Aoki, Yuko, Klumpp, Klaus, Tsukiyama–Kohara, Kyoko, El–Gohary, Ahmed, Sudoh, Masayuki, Kohara, Michinori

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Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus von Hang, Julie Qi, Yang, Yanli, Harris, Seth F., Leveque, Vincent, Whittington, Hannah J., Rajyaguru, Sonal, Ao-Ieong, Gloria, McCown, Matthew F., Wong, April, Giannetti, Anthony M., Le Pogam, Sophie, Talamás, Francisco, Cammack, Nick, Nájera, Isabel, Klumpp, Klaus

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In vitro selected Con1 subgenomic replicons resistant to 2′-C-Methyl-Cytidine or to R1479 show lack of cross resistance von Le Pogam, Sophie, Jiang, Wen-Rong, Leveque, Vincent, Rajyaguru, Sonal, Ma, Han, Kang, Hyunsoon, Jiang, Sharon, Singer, Margaret, Ali, Samir, Klumpp, Klaus, Smith, Dave, Symons, Julian, Cammack, Nick, Nájera, Isabel

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Essential Role of the N-terminal Domain in the Regulation of RIG-I ATPase Activity von Gee, Peter, Chua, Pong Kian, Gevorkyan, Jirair, Klumpp, Klaus, Najera, Isabel, Swinney, David C., Deval, Jerome

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Structure of the Unphosphorylated STAT5a Dimer von Neculai, Dante, Neculai, Ana Mirela, Verrier, Sophie, Straub, Kenneth, Klumpp, Klaus, Pfitzner, Edith, Becker, Stefan

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Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus von LE POGAM, Sophie, KANG, Hyunsoon, HENDRICKS, Than, KLUMPP, Klaus, SYMONS, Julian, BROWNER, Michelle F, CAMMACK, Nick, NAJERA, Isabel, HARRIS, Seth F, LEVEQUE, Vincent, GIANNETTI, Anthony M, ALI, Samir, JIANG, Wen-Rong, RAJYAGURU, Sonal, TAVARES, Gisele, OSHIRO, Connie

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First Example of Phosphoramidate Approach Applied to a 4‘-Substituted Purine Nucleoside (4‘-Azidoadenosine):  Conversion of an Inactive Nucleoside to a Submicromolar Compound versu... von Perrone, Plinio, Daverio, Felice, Valente, Rocco, Rajyaguru, Sonal, Martin, Joseph A, Lévêque, Vincent, Pogam, Sophie Le, Najera, Isabel, Klumpp, Klaus, Smith, David B, McGuigan, Christopher

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Use of a Pharmacophore Model To Discover a New Class of Influenza Endonuclease Inhibitors von Parkes, Kevin E. B, Ermert, Philipp, Fässler, Jürg, Ives, Jane, Martin, Joseph A, Merrett, John H, Obrecht, Daniel, Williams, Glyn, Klumpp, Klaus

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Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs) von Hang, Julie Q., Li, Yu, Yang, Yanli, Cammack, Nick, Mirzadegan, Tara, Klumpp, Klaus

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Target-mediated drug disposition and prolonged liver accumulation of a novel humanized anti-CD81 monoclonal antibody in cynomolgus monkeys von Vexler, Vladimir, Yu, Li, Pamulapati, Chandrasena, Garrido, Rosario, Grimm, Hans Peter, Sriraman, Priya, Bohini, Sandhya, Schraeml, Michael, Singh, Usha, Brandt, Michael, Ries, Stefan, Ma, Han, Klumpp, Klaus, Ji, Changhua

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