The discovery of zinc fingers and their applications in gene regulation and genome manipulation von Klug, Aaron

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The discovery of zinc fingers and their development for practical applications in gene regulation and genome manipulation von Klug, Aaron

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Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA von Minczuk, Michal, Papworth, Monika A, Miller, Jeffrey C, Murphy, Michael P, Klug, Aaron

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Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases von Santiago, Yolanda, Chan, Edmond, Liu, Pei-Qi, Orlando, Salvatore, Zhang, Lin, Urnov, Fyodor D, Holmes, Michael C, Guschin, Dmitry, Waite, Adam, Miller, Jeffrey C, Rebar, Edward J, Gregory, Philip D, Klug, Aaron, Collingwood, Trevor N

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Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase von Minczuk, Michal, Papworth, Monika A, Kolasinska, Paulina, Murphy, Michael P, Klug, Aaron

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Mutation in the Tau Gene in Familial Multiple System Tauopathy with Presenile Dementia von Spillantini, Maria Grazia, Murrell, Jill R., Goedert, Michel, Farlow, Martin R., Klug, Aaron, Ghetti, Bernardino

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Crystal structure of a zinc-finger–RNA complex reveals two modes of molecular recognition von Lu, Duo, Alexandra Searles, M., Klug, Aaron

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A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter von Isalan, Mark, Klug, Aaron, Choo, Yen

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The crystal structure of an AII-RNAhammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage von Scott, William G., Finch, John T., Klug, Aaron

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Improved DNA Binding Specificity from Polyzinc Finger Peptides by Using Strings of Two-Finger Units von Moore, Michael, Klug, Aaron, Choo, Yen

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Physical basis of a protein-DNA recognition code von Choo, Yen, Klug, Aaron

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From virus structure to chromatin: X-ray diffraction to three-dimensional electron microscopy von Klug, Aaron

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Repression of the HIV-1 5′ LTR Promoter and Inhibition of HIV-1 Replication by Using Engineered Zinc-Finger Transcription Factors von Reynolds, Lindsey, Ullman, Christopher, Moore, Michael, Isalan, Mark, West, Michelle J., Clapham, Paul, Klug, Aaron, Choo, Yen

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Structure of Tau Exon 10 Splicing Regulatory Element RNA and Destabilization by Mutations of Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 von Varani, Luca, Hasegawa, Masato, Spillantini, Maria Grazia, Smith, Michael J., Murrell, Jill R., Ghetti, Bernardino, Klug, Aaron, Goedert, Michel, Varani, Gabriele

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Inhibition of Herpes Simplex Virus 1 Gene Expression by Designer Zinc-Finger Transcription Factors von Papworth, Monika, Moore, Michael, Isalan, Mark, Minczuk, Michal, Choo, Yen, Klug, Aaron

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Capturing the Structure of a Catalytic RNA Intermediate: The Hammerhead Ribozyme von Scott, William G., Murray, James B., John R. P. Arnold, Stoddard, Barry L., Klug, Aaron

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Synergy between Adjacent Zinc Fingers in Sequence-Specific DNA Recognition von Isalan, Mark, Choo, Yen, Klug, Aaron

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Comprehensive DNA Recognition through Concerted Interactions from Adjacent Zinc Fingers von Isalan, Mark, Klug, Aaron, Choo, Yen

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Francis Crick (8th June 1916 – 28th July 2004) von Klug, Aaron

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Design of Polyzinc Finger Peptides with Structured Linkers von Moore, Michael, Choo, Yen, Klug, Aaron

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