Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results von Rovite, Vita, Wolff-Sagi, Yael, Zaharenko, Linda, Nikitina-Zake, Liene, Grens, Elmars, Klovins, Janis

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Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues von Zake, Darta Maija, Kurlovics, Janis, Zaharenko, Linda, Komasilovs, Vitalijs, Klovins, Janis, Stalidzans, Egils

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Hydroxycarboxylic Acid Receptor Ligands Modulate Proinflammatory Cytokine Expression in Human Macrophages and Adipocytes without Affecting Adipose Differentiation von Mandrika, Ilona, Tilgase, Andra, Petrovska, Ramona, Klovins, Janis

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Association of metformin administration with gut microbiome dysbiosis in healthy volunteers von Elbere, Ilze, Kalnina, Ineta, Silamikelis, Ivars, Konrade, Ilze, Zaharenko, Linda, Sekace, Kristine, Radovica-Spalvina, Ilze, Fridmanis, Davids, Gudra, Dita, Pirags, Valdis, Klovins, Janis

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ACTH Receptor (MC2R) Specificity: What Do We Know About Underlying Molecular Mechanisms? von Fridmanis, Davids, Roga, Ance, Klovins, Janis

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Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients von Elbere, Ilze, Silamikelis, Ivars, Dindune, Ilze Izabella, Kalnina, Ineta, Ustinova, Monta, Zaharenko, Linda, Silamikele, Laila, Rovite, Vita, Gudra, Dita, Konrade, Ilze, Sokolovska, Jelizaveta, Pirags, Valdis, Klovins, Janis

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Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations von Tambets, Kristiina, Yunusbayev, Bayazit, Hudjashov, Georgi, Ilumäe, Anne-Mai, Rootsi, Siiri, Honkola, Terhi, Vesakoski, Outi, Atkinson, Quentin, Skoglund, Pontus, Kushniarevich, Alena, Litvinov, Sergey, Reidla, Maere, Metspalu, Ene, Saag, Lehti, Rantanen, Timo, Karmin, Monika, Parik, Jüri, Zhadanov, Sergey I, Gubina, Marina, Damba, Larisa D, Bermisheva, Marina, Reisberg, Tuuli, Dibirova, Khadizhat, Evseeva, Irina, Nelis, Mari, Klovins, Janis, Metspalu, Andres, Esko, Tõnu, Balanovsky, Oleg, Balanovska, Elena, Khusnutdinova, Elza K, Osipova, Ludmila P, Voevoda, Mikhail, Villems, Richard, Kivisild, Toomas, Metspalu, Mait

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Evaluating the Efficacy of Type 2 Diabetes Polygenic Risk Scores in an Independent European Population von Brīvība, Monta, Atava, Ivanna, Pečulis, Raitis, Elbere, Ilze, Ansone, Laura, Rozenberga, Maija, Silamiķelis, Ivars, Kloviņš, Jānis

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Whole exome sequencing reveals novel risk genes of pituitary neuroendocrine tumors von Peculis, Raitis, Rovite, Vita, Megnis, Kaspars, Balcere, Inga, Breiksa, Austra, Nazarovs, Jurijs, Stukens, Janis, Konrade, Ilze, Sokolovska, Jelizaveta, Pirags, Valdis, Klovins, Janis

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Amino Acid Metabolism is Significantly Altered at the Time of Admission in Hospital for Severe COVID-19 Patients: Findings from Longitudinal Targeted Metabolomics Analysis von Ansone, Laura, Briviba, Monta, Silamikelis, Ivars, Terentjeva, Anna, Perkons, Ingus, Birzniece, Liga, Rovite, Vita, Rozentale, Baiba, Viksna, Ludmila, Kolesova, Oksana, Klavins, Kristaps, Klovins, Janis

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Exploring disease-specific metabolite signatures in hereditary angioedema patients von Kanepa, Adine, Fan, Jingzhi, Rots, Dmitrijs, Vaska, Annija, Ansone, Laura, Briviba, Monta, Klovins, Janis, Kurjane, Natalja, Klavins, Kristaps

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Metformin Strongly Affects Gut Microbiome Composition in High-Fat Diet-Induced Type 2 Diabetes Mouse Model of Both Sexes von Silamikele, Laila, Silamikelis, Ivars, Ustinova, Monta, Kalnina, Zane, Elbere, Ilze, Petrovska, Ramona, Kalnina, Ineta, Klovins, Janis

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Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals von Ustinova, Monta, Silamikelis, Ivars, Kalnina, Ineta, Ansone, Laura, Rovite, Vita, Elbere, Ilze, Radovica-Spalvina, Ilze, Fridmanis, Davids, Aladyeva, Jekaterina, Konrade, Ilze, Pirags, Valdis, Klovins, Janis

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Whole-blood transcriptome profiling reveals signatures of metformin and its therapeutic response von Ustinova, Monta, Ansone, Laura, Silamikelis, Ivars, Rovite, Vita, Elbere, Ilze, Silamikele, Laila, Kalnina, Ineta, Fridmanis, Davids, Sokolovska, Jelizaveta, Konrade, Ilze, Pirags, Valdis, Klovins, Janis

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Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation von Ansone, Laura, Rovite, Vita, Brīvība, Monta, Jagare, Lauma, Pelcmane, Līva, Borisova, Daniella, Thews, Anne, Leiminger, Roland, Kloviņš, Jānis

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Changes in the type 2 diabetes gut mycobiome associate with metformin treatment across populations von Van Syoc, Emily, Nixon, Michelle Pistner, Silverman, Justin D, Luo, Yuhong, Gonzalez, Frank J, Elbere, Ilze, Klovins, Janis, Patterson, Andrew D, Rogers, Connie J, Ganda, Erika

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Genetic structure of Europeans: a view from the North-East von Nelis, Mari, Esko, Tõnu, Mägi, Reedik, Zimprich, Fritz, Zimprich, Alexander, Toncheva, Draga, Karachanak, Sena, Piskácková, Tereza, Balascák, Ivan, Peltonen, Leena, Jakkula, Eveliina, Rehnström, Karola, Lathrop, Mark, Heath, Simon, Galan, Pilar, Schreiber, Stefan, Meitinger, Thomas, Pfeufer, Arne, Wichmann, H-Erich, Melegh, Béla, Polgár, Noémi, Toniolo, Daniela, Gasparini, Paolo, D'Adamo, Pio, Klovins, Janis, Nikitina-Zake, Liene, Kucinskas, Vaidutis, Kasnauskiene, Jūrate, Lubinski, Jan, Debniak, Tadeusz, Limborska, Svetlana, Khrunin, Andrey, Estivill, Xavier, Rabionet, Raquel, Marsal, Sara, Julià, Antonio, Antonarakis, Stylianos E, Deutsch, Samuel, Borel, Christelle, Attar, Homa, Gagnebin, Maryline, Macek, Milan, Krawczak, Michael, Remm, Maido, Metspalu, Andres

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Case Report: Micro-RNAs in Plasma From Bilateral Inferior Petrosal Sinus Sampling and Peripheral Blood From Corticotroph Pituitary Neuroendocrine Tumors von Niedra, Helvijs, Peculis, Raitis, Konrade, Ilze, Balcere, Inga, Romanovs, Mihails, Steina, Liva, Stukens, Janis, Sokolovska, Jelizaveta, Klovins, Janis, Rovite, Vita

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Single-Cell RNA Sequencing Reveals Alterations in Patient Immune Cells with Pulmonary Long COVID-19 Complications von Vaivode, Kristīne, Saksis, Rihards, Litvina, Helēna Daiga, Niedra, Helvijs, Spriņģe, Marta Līva, Krūmiņa, Una, Kloviņš, Jānis, Rovite, Vita

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Metformin targets intestinal immune system signaling pathways in a high-fat diet-induced mouse model of obesity and insulin resistance von Brīvība, Monta, Silamiķele, Laila, Kalniņa, Ineta, Silamiķelis, Ivars, Birzniece, Līga, Ansone, Laura, Jagare, Lauma, Elbere, Ilze, Kloviņš, Jānis

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