Albumin-bound nanoparticle (nab) paclitaxel exhibits enhanced paclitaxel tissue distribution and tumor penetration von Chen, Nianhang, Brachmann, Carrie, Liu, Xiping, Pierce, Daniel W., Dey, Joyoti, Kerwin, William S., Li, Yan, Zhou, Simon, Hou, Shihe, Carleton, Michael, Klinghoffer, Richard A., Palmisano, Maria, Chopra, Rajesh

Volltext

Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition von Dey, Joyoti, Deckwerth, Thomas L., Kerwin, William S., Casalini, Joseph R., Merrell, Angela J., Grenley, Marc O., Burns, Connor, Ditzler, Sally H., Dixon, Chantel P., Beirne, Emily, Gillespie, Kate C., Kleinman, Edward F., Klinghoffer, Richard A.

Volltext

Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment von Derry, Jonathan M J, Burns, Connor, Frazier, Jason P, Beirne, Emily, Grenley, Marc, DuFort, Christopher C, Killingbeck, Emily, Leon, Michael, Williams, Claire, Gregory, Mark, Houlton, Jeffrey, Clayburgh, Daniel, Swiecicki, Paul, Huszar, Dennis, Berger, Allison, Klinghoffer, Richard A

Volltext

Combination of the mTOR inhibitor ridaforolimus and the anti-IGF1R monoclonal antibody dalotuzumab: preclinical characterization and phase I clinical trial von Di Cosimo, Serena, Sathyanarayanan, Sriram, Bendell, Johanna C, Cervantes, Andrés, Stein, Mark N, Braña, Irene, Roda, Desamparados, Haines, Brian B, Zhang, Theresa, Winter, Christopher G, Jha, Sharda, Xu, Youyuan, Frazier, Jason, Klinghoffer, Richard A, Leighton-Swayze, Ann, Song, Yang, Ebbinghaus, Scot, Baselga, José

Volltext

Evolutionary Divergence of Platelet-Derived Growth Factor Alpha Receptor Signaling Mechanisms von Hamilton, T. Guy, Klinghoffer, Richard A., Corrin, Philip D., Soriano, Philippe

Volltext

Protein Tyrosine Phosphatase Epsilon Affects Body Weight by Downregulating Leptin Signaling in a Phosphorylation-Dependent Manner von Rousso-Noori, Liat, Knobler, Hilla, Levy-Apter, Einat, Kuperman, Yael, Neufeld-Cohen, Adi, Keshet, Yonat, Akepati, Vasudheva R., Klinghoffer, Richard A., Chen, Alon, Elson, Ari

Volltext

A Platform for Rapid, Quantitative Assessment of Multiple Drug Combinations Simultaneously in Solid Tumors In Vivo von Dey, Joyoti, Kerwin, William S, Grenley, Marc O, Casalini, Joseph R, Tretyak, Ilona, Ditzler, Sally H, Thirstrup, Derek J, Frazier, Jason P, Pierce, Daniel W, Carleton, Michael, Klinghoffer, Richard A

Volltext

Multidrug Analyses in Patients Distinguish Efficacious Cancer Agents Based on Both Tumor Cell Killing and Immunomodulation von Frazier, Jason P, Bertout, Jessica A, Kerwin, William S, Moreno-Gonzalez, Alicia, Casalini, Joey R, Grenley, Marc O, Beirne, Emily, Watts, Kori L, Keener, Andy, Thirstrup, Derek J, Tretyak, Ilona, Ditzler, Sally H, Tripp, Chelsea D, Choy, Kevin, Gillings, Sarah, Breit, Megan N, Meleo, Karri A, Rizzo, Vanessa, Herrera, Chamisa L, Perry, James A, Amaravadi, Ravi K, Olson, James M, Klinghoffer, Richard A

Volltext

Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients with Soft Tissue Sarcoma von Gundle, Kenneth R, Deutsch, Gary B, Goodman, Howard J, Pollack, Seth M, Thompson, Matthew J, Davis, Jessica L, Lee, Mee-Young, Ramirez, Daniel C, Kerwin, William, Bertout, Jessica A, Grenley, Marc O, Sottero, Kimberly H W, Beirne, Emily, Frazier, Jason, Dey, Joyoti, Ellison, Micah, Klinghoffer, Richard A, Maki, Robert G

Volltext

Early, precise, and safe clinical evaluation of the pharmacodynamic effects of novel agents in the intact human tumor microenvironment von Gundle, Kenneth R, Rajasekaran, Karthik, Houlton, Jeffrey, Deutsch, Gary B, Ow, Thomas J, Maki, Robert G, Pang, John, Nathan, Cherie-Ann O, Clayburgh, Daniel, Newman, Jason G, Brinkmann, Elyse, Wagner, Michael J, Pollack, Seth M, Thompson, Matthew J, Li, Ryan J, Mehta, Vikas, Schiff, Bradley A, Wenig, Barry I, Swiecicki, Paul L, Tang, Alice L, Davis, Jessica L, van Zante, Annemieke, Bertout, Jessica A, Jenkins, Wendy, Turner, Atticus, Grenley, Marc, Burns, Connor, Frazier, Jason P, Merrell, Angela, Sottero, Kimberly H W, Derry, Jonathan M J, Gillespie, Kate C, Mills, Bre, Klinghoffer, Richard A

Volltext

Src family kinases are required for integrin but not PDGFR signal transduction von Klinghoffer, Richard A., Sachsenmaier, Christoph, Cooper, Jonathan A., Soriano, Philippe

Volltext

A modified gene trap approach for improved high-throughput cancer drug discovery von Morris, Shelli M., Mhyre, Andrew J., Carmack, Savanna S., Myers, Carrie H., Burns, Connor, Ye, Wenjuan, Ferrer, Marc, Olson, James M., Klinghoffer, Richard A.

Volltext

Minimally invasive in tumor multidrug comparative analysis with contrast-enhanced MRI in mice von Kerwin, William S., Tretyak, Ilona, Grenley, Marc O., You, Sheng, Hatton, Beryl A., Moreno-Gonzalez, Alicia, Thirstrup, Derek J., Klinghoffer, Richard A.

Volltext

Src Catalytic but Not Scaffolding Function Is Needed for Integrin-Regulated Tyrosine Phosphorylation, Cell Migration, and Cell Spreading von Cary, Leslie A., Klinghoffer, Richard A., Sachsenmaier, Christoph, Cooper, Jonathan A.

Volltext

Reduced seed region-based off-target activity with lentivirus-mediated RNAi von Klinghoffer, Richard A, Magnus, Jill, Schelter, Janell, Mehaffey, Michele, Coleman, Casey, Cleary, Michele A

Volltext

Growth factor signaling pathways in vascular development von Tallquist, M D, Soriano, P, Klinghoffer, R A

Volltext

722 Evaluation of the effects of pembrolizumab alone and in combination(s) with MDSC-targeting agents MK-0482 and MK-4830 on the native cancer patient TME via functional spatial pr... von Gundle, Kenneth, Rajasekaran, Karthik, Houlton, Jeffrey, Clayburgh, Daniel, Wagner, Michael, Brinkmann, Elyse, Nathan, Cherie-Ann, Pang, John, Zante, Annemieke Van, Davis, Jessica, Burns, Connor, Frazier, Jason, Beirne, Emily, Merrell, Angela, Mills, Bre, Derry, Jonathan, Sang, Hanrong, Turner, Atticus, Grenley, Marc, Schauer, Nathan, Jenkins, Wendy, Klinghoffer, Richard

Volltext

The Two PDGF Receptors Maintain Conserved Signaling In Vivo despite Divergent Embryological Functions von Klinghoffer, Richard A, Mueting-Nelsen, Peter F, Faerman, Alexander, Shani, Moshe, Soriano, Philippe

Volltext

A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling von Klinghoffer, Richard A, Frazier, Jason, Annis, James, Berndt, Jason D, Roberts, Brian S, Arthur, William T, Lacson, Raul, Zhang, Xiaohua Douglas, Ferrer, Marc, Moon, Randall T, Cleary, Michele A

Volltext

Predicting responses to chemotherapy in the context that matters - the patient von Moreno-Gonzalez, Alicia, Olson, James M., Klinghoffer, Richard A.

Volltext