Engineered CAR-Macrophages as Adoptive Immunotherapies for Solid Tumors von Sloas, Christopher, Gill, Saar, Klichinsky, Michael

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Human chimeric antigen receptor macrophages for cancer immunotherapy von Klichinsky, Michael, Ruella, Marco, Shestova, Olga, Lu, Xueqing Maggie, Best, Andrew, Zeeman, Martha, Schmierer, Maggie, Gabrusiewicz, Konrad, Anderson, Nicholas R., Petty, Nicholas E., Cummins, Katherine D., Shen, Feng, Shan, Xinhe, Veliz, Kimberly, Blouch, Kristin, Yashiro-Ohtani, Yumi, Kenderian, Saad S., Kim, Miriam Y., O’Connor, Roddy S., Wallace, Stephen R., Kozlowski, Miroslaw S., Marchione, Dylan M., Shestov, Maksim, Garcia, Benjamin A., June, Carl H., Gill, Saar

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Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies von Ruella, Marco, Barrett, David M, Kenderian, Saad S, Shestova, Olga, Hofmann, Ted J, Perazzelli, Jessica, Klichinsky, Michael, Aikawa, Vania, Nazimuddin, Farzana, Kozlowski, Miroslaw, Scholler, John, Lacey, Simon F, Melenhorst, Jan J, Morrissette, Jennifer J D, Christian, David A, Hunter, Christopher A, Kalos, Michael, Porter, David L, June, Carl H, Grupp, Stephan A, Gill, Saar

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EBV latency types adopt alternative chromatin conformations von Tempera, Italo, Klichinsky, Michael, Lieberman, Paul M

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An Atlas of the Epstein-Barr Virus Transcriptome and Epigenome Reveals Host-Virus Regulatory Interactions von Arvey, Aaron, Tempera, Italo, Tsai, Kevin, Chen, Horng-Shen, Tikhmyanova, Nadezhda, Klichinsky, Michael, Leslie, Christina, Lieberman, Paul M.

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Chimeric antigen receptor macrophages (CAR-M) sensitize HER2+ solid tumors to PD1 blockade in pre-clinical models von Pierini, Stefano, Gabbasov, Rashid, Oliveira-Nunes, Maria Cecilia, Qureshi, Rehman, Worth, Alison, Huang, Shuo, Nagar, Karan, Griffin, Crystal, Lian, Lurong, Yashiro-Ohtani, Yumi, Ross, Kayleigh, Sloas, Christopher, Ball, Michael, Schott, Benjamin, Sonawane, Poonam, Cornell, Linara, Blumenthal, Daniel, Chhum, Sotheavy, Minutolo, Nicholas, Ciccaglione, Kerri, Shaw, Lauren, Zentner, Isaac, Levitsky, Hyam, Shestova, Olga, Gill, Saar, Varghese, Bindu, Cushing, Daniel, Ceeraz DeLong, Sabrina, Abramson, Sascha, Condamine, Thomas, Klichinsky, Michael

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Macrophage-Based Approaches for Cancer Immunotherapy von Anderson, Nicholas R, Minutolo, Nicholas G, Gill, Saar, Klichinsky, Michael

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389 Engineered microenvironment converters (EM-C): macrophages expressing synthetic cytokine receptors reverse immunosuppressive signals in solid tumors von Sloas, Chris, Huangfu, Yuhao, Beghi, Silvia, Qureshi, Rehman, Ball, Michael, Blumenthal, Daniel, Condamine, Thomas, Klichinsky, Michael, Ohtani, Yumi

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132 CAR macrophages (CAR-M) elicit a systemic anti-tumor immune response and synergize with PD1 blockade in immunocompetent mouse models of HER2+ solid tumors von Pierini, Stefano, Gabbasov, Rashid, Gabitova, Linara, Ohtani, Yumi, Klichinsky, Michael

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A fungal protease allergen provokes airway hyper-responsiveness in asthma von Balenga, Nariman A., Klichinsky, Michael, Xie, Zhihui, Chan, Eunice C., Zhao, Ming, Jude, Joseph, Laviolette, Michel, Panettieri, Reynold A., Druey, Kirk M.

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951 A phase 1 first in human study of adenovirally transduced anti-HER2 CAR macrophages in subjects with HER2 overexpressing solid tumors: preliminary safety, pharmacokinetics, and... von Reiss, Kim, Yuan, Yuan, Barton, Debora, Ronczka, Amy, Cushing, Daniel, Klichinsky, Michael, Abramson, Sascha, Qureshi, Rehman, Condamine, Thomas, Dees, Elizabeth

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307 CAR-Macrophages with custom intronic shRNA exhibit enhanced efficacy against solid tumors von Sloas, Chris, Gabbasov, Rashid, Anderson, Nicholas, Huangfu, Yuhao, Nagar, Karan, Ciccaglione, Kerri, Tobin, Tierra, Minutolo, Nicholas, Condamine, Thomas, Klichinsky, Michael, Ohtani, Yumi

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635 A phase 1, first in human (FIH) study of autologous macrophages engineered to express an anti-HER2 chimeric antigen receptor (CAR) in participants (pts) with HER2 overexpressin... von Reiss, Kim, Mortimer, Joanne, Pohlmann, Paula R, Johnson, Melissa, Maziarz, Richard T, Specht, Jennifer, Claire Dees, E, Yuan, Yuan, Ueno, Naoto, Angelos, Mathew, Gill, Saar, Condamine, Thomas, Cushing, Daniel, Barton, Debora, Klichinsky, Michael, Swaby, Ramona F, Abdou, Yara

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1514 In vivo CAR-M: redirecting endogenous myeloid cells with mRNA for cancer immunotherapy von Varghese, Bindu, Mori, Simone, Pierini, Stefano, Bagashev, Asen, Ohtani, Yumi, Gabbasov, Rashid, Ross, Kayleigh, Huang, Shuo, Bona, Amanda, Merdiana, Sherly, Slovik, Kate, Worth, Alison, Nagar, Karan, Saporito, Robert, Shaw, Lauren, Ball, Michael, Qureshi, Rehman, Minutolo, Nicholas, Tosh, Kevin, Lee, Claudia, Lukacs, Christine, Guey, Lin, Klichinsky, Michael, Condamine, Thomas

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139 Chimeric antigen receptor macrophages (CAR-M) elicit a systemic anti-tumor immune response and synergize with PD1 blockade in immunocompetent mouse models of HER2+ solid tumors... von Pierini, Stefano, Klichinsky, Michael, Gabbasov, Rashid, Worth, Alison, Ramos, Ilyssa, Blumenthal, Daniel, Gabitova, Linara, Abramson, Sascha, Condamine, Thomas, Ball, Michael, Ohtani, Yumi

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104 Development and characterization of human chimeric antigen receptor monocytes (CAR-Mono), a novel cell therapy platform von Blumenthal, Daniel, Gabitova, Linara, Menchel, Brett, Reyes-Uribe, Patricia, Best, Andrew, Lynch, Michael, Chhum, Sotheavy, Schmierer, Maggie, Abramson, Sascha, Klichinsky, Michael

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Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells von Ruella, Marco, Klichinsky, Michael, Kenderian, Saad S, Shestova, Olga, Ziober, Amy, Kraft, Daniel O, Feldman, Michael, Wasik, Mariusz A, June, Carl H, Gill, Saar

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Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell von Ruella, Marco, Xu, Jun, Barrett, David M., Fraietta, Joseph A., Reich, Tyler J., Ambrose, David E., Klichinsky, Michael, Shestova, Olga, Patel, Prachi R., Kulikovskaya, Irina, Nazimuddin, Farzana, Bhoj, Vijay G., Orlando, Elena J., Fry, Terry J., Bitter, Hans, Maude, Shannon L., Levine, Bruce L., Nobles, Christopher L., Bushman, Frederic D., Young, Regina M., Scholler, John, Gill, Saar I., June, Carl H., Grupp, Stephan A., Lacey, Simon F., Melenhorst, J. Joseph

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Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia von Kim, Miriam Y., Yu, Kyung-Rok, Kenderian, Saad S., Ruella, Marco, Chen, Shirley, Shin, Tae-Hoon, Aljanahi, Aisha A., Schreeder, Daniel, Klichinsky, Michael, Shestova, Olga, Kozlowski, Miroslaw S., Cummins, Katherine D., Shan, Xinhe, Shestov, Maksim, Bagg, Adam, Morrissette, Jennifer J.D., Sekhri, Palak, Lazzarotto, Cicera R., Calvo, Katherine R., Kuhns, Douglas B., Donahue, Robert E., Behbehani, Gregory K., Tsai, Shengdar Q., Dunbar, Cynthia E., Gill, Saar

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Abstract OT1-03-01: A phase 1, first in human (FIH) study of adenovirally transduced autologous macrophages engineered to contain an anti-HER2 chimeric antigen receptor (CAR) in su... von Abdou, Yara George, Barton, Debora, Ronczka, Amy, Cushing, Daniel, Klichinsky, Michael, Binder, Kim Reiss

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