Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120) von Roth, Gerald J, Heckel, Armin, Colbatzky, Florian, Handschuh, Sandra, Kley, Jörg, Lehmann-Lintz, Thorsten, Lotz, Ralf, Tontsch-Grunt, Ulrike, Walter, Rainer, Hilberg, Frank

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The azulene scaffold from a medicinal chemist's perspective: Physicochemical and in vitro parameters relevant for drug discovery von Leino, Teppo O., Sieger, Peter, Yli-Kauhaluoma, Jari, Wallén, Erik A.A., Kley, Jörg T.

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Discovery and development of BI 1265162, an ENaC inhibitor for the treatment of cystic fibrosis von Betzemeier, Bodo, Braun, Clemens, Sieger, Peter, Heckel, Armin, Linz, Günter, Linehan, Brian, Veser, Thomas, Wiedenmayer, Dieter, Kley, Jörg T.

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Discovery of BI 99179, a potent and selective inhibitor of type I fatty acid synthase with central exposure von Kley, Jörg T., Mack, Jürgen, Hamilton, Bradford, Scheuerer, Stefan, Redemann, Norbert

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Chemical Derivatization Enables MALDI-TOF-Based High-Throughput Screening for Microbial Trimethylamine (TMA)-Lyase Inhibitors von Winter, Martin, Bretschneider, Tom, Thamm, Sven, Kleiner, Carola, Grabowski, Daniel, Chandler, Sarah, Ries, Robert, Kley, Jörg T., Fowler, Danielle, Bartlett, Christina, Binetti, Ralph, Broadwater, John, Luippold, Andreas H., Bischoff, Daniel, Büttner, Frank H.

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Design, synthesis and evaluation of MCH receptor 1 antagonists—Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition von Roth, Gerald J., Heckel, Armin, Kley, Jörg T., Lehmann, Thorsten, Müller, Stephan G., Oost, Thorsten, Rudolf, Klaus, Arndt, Kirsten, Budzinski, Ralph, Lenter, Martin, Lotz, Ralf R.H., Schindler, Marcus, Thomas, Leo, Stenkamp, Dirk

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Design, synthesis and evaluation of MCH receptor 1 antagonists—Part III: Discovery of pre-clinical development candidate BI 186908 von Oost, Thorsten, Heckel, Armin, Kley, Jörg T., Lehmann, Thorsten, Müller, Stephan, Roth, Gerald J., Rudolf, Klaus, Arndt, Kirsten, Budzinski, Ralph, Lenter, Martin, Lotz, Ralf R.H., Maier, Gerd-Michael, Markert, Michael, Thomas, Leo, Stenkamp, Dirk

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Design, synthesis and evaluation of MCH receptor 1 antagonists—Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414 von Müller, Stephan G., Heckel, Armin, Kley, Jörg T., Lehmann, Thorsten, Lustenberger, Philipp, Oost, Thorsten, Roth, Gerald J., Rudolf, Klaus, Arndt, Kirsten, Lenter, Martin, Lotz, Ralf R.H., Maier, Gerd-Michael, Markert, Michael, Schindler, Marcus, Stenkamp, Dirk

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Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability von Heine, Niklas, Weber, Alexander, Pautsch, Alexander, Gottschling, Dirk, Uphues, Ingo, Bauer, Margit, Ebenhoch, Rebecca, Magarkar, Aniket, Nosse, Bernd, Kley, Jörg Thomas

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Crystal structures of human and mouse ketohexokinase provide a structural basis for species- and isoform-selective inhibitor design von Ebenhoch, Rebecca, Bauer, Margit, Romig, Helmut, Gottschling, Dirk, Kley, Jörg Thomas, Heine, Niklas, Weber, Alexander, Uphues, Ingo, Nar, Herbert, Pautsch, Alexander

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Cytotoxic Efficacy and Influence on Cellular Phospholipid Metabolism of 2-Hydroxy- and 2-O-Acetyl-Octadecylphosphocholines von HILDENBRAND, Bernd, KLEY, Jörg T, HABERSTROH, Frank, FREUDENBERG, Marina A, AZEMAR, Marc, UNGER, Clemens, MASSING, Ulrich

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Targeting of endothelial KDR receptors with 3G2 immunoliposomes in vitro von Benzinger, Petra, Martiny-Baron, Georg, Reusch, Petra, Siemeister, Gerd, Kley, Jörg T, Marmé, Dieter, Unger, Clemens, Massing, Ulrich

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Heteroaromatic Decarboxylative Claisen Rearrangement Reactions von Craig, Donald, King, N. Paul, Kley, Jörg T., Mountford, David M.

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AMILORIDE-TYPE COMPOUNDS AS INHIBITORS IN EPITHELIAL SODIUM CHANNELS FOR THE TREATMENT OF DISEASES OF THE LUNGS AND AIRWAYS von HECKEL, Armin, KLEY, Jörg

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AMILORIDE-TYPE COMPOUNDS AS INHIBITORS IN EPITHELIAL SODIUM CHANNELS FOR THE TREATMENT OF DISEASES OF THE LUNGS AND AIRWAYS von HECKEL, ARMIN, KLEY, JÖRG

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AMILORIDE-TYPE COMPOUNDS AS INHIBITORS IN EPITHELIAL SODIUM CHANNELS FOR THE TREATMENT OF DISEASES OF THE LUNGS AND AIRWAYS von HECKEL, ARMIN, KLEY, JÖRG

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A simple approach to DOTAP and its analogs bearing different fatty acids von Massing, Ulrich, Kley, Jörg T., Gürtesch, Laura, Fankhaenel, Stefan

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NOVEL 5-SUBSTITUTED BENZIMIDAZOLIUM COMPOUNDS von HECKEL, Armin, KLEY, Jörg, FRATTINI, Sara, HAMPRECHT, Dieter

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NOVEL TETRA- AND PENTASUBSTITUTED BENZIMIDAZOLIUM COMPOUNDS von KLEY, Jörg, FRATTINI, Sara, HAMPRECHT, Dieter

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NOVEL BENZIMIDAZOLIUM COMPOUNDS von KLEY, Jörg, FRATTINI, Sara, HAMPRECHT, Dieter

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