Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants von Walton, Russell T, Christie, Kathleen A, Whittaker, Madelynn N, Kleinstiver, Benjamin P

Volltext

Precise cut-and-paste DNA insertion using engineered type V-K CRISPR-associated transposases von Tou, Connor J., Orr, Benno, Kleinstiver, Benjamin P.

Volltext

Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition von Kleinstiver, Benjamin P, Prew, Michelle S, Tsai, Shengdar Q, Nguyen, Nhu T, Topkar, Ved V, Zheng, Zongli, Joung, J Keith

Volltext

Enhanced proofreading governs CRISPR–Cas9 targeting accuracy von Chen, Janice S., Dagdas, Yavuz S., Kleinstiver, Benjamin P., Welch, Moira M., Sousa, Alexander A., Harrington, Lucas B., Sternberg, Samuel H., Joung, J. Keith, Yildiz, Ahmet, Doudna, Jennifer A.

Volltext

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects von Kleinstiver, Benjamin P., Pattanayak, Vikram, Prew, Michelle S., Tsai, Shengdar Q., Nguyen, Nhu T., Zheng, Zongli, Joung, J. Keith

Volltext

Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells von Wünnemann, Florian, Fotsing Tadjo, Thierry, Beaudoin, Mélissa, Lalonde, Simon, Lo, Ken Sin, Kleinstiver, Benjamin P, Lettre, Guillaume

Volltext

Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells von Kleinstiver, Benjamin P, Tsai, Shengdar Q, Prew, Michelle S, Nguyen, Nhu T, Welch, Moira M, Lopez, Jose M, McCaw, Zachary R, Aryee, Martin J, Joung, J Keith

Volltext

Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease von McAlpine, Cameron S., Park, Joseph, Griciuc, Ana, Kim, Eunhee, Choi, Se Hoon, Iwamoto, Yoshiko, Kiss, Máté G., Christie, Kathleen A., Vinegoni, Claudio, Poller, Wolfram C., Mindur, John E., Chan, Christopher T., He, Shun, Janssen, Henrike, Wong, Lai Ping, Downey, Jeffrey, Singh, Sumnima, Anzai, Atsushi, Kahles, Florian, Jorfi, Mehdi, Feruglio, Paolo Fumene, Sadreyev, Ruslan I., Weissleder, Ralph, Kleinstiver, Benjamin P., Nahrendorf, Matthias, Tanzi, Rudolph E., Swirski, Filip K.

Volltext

Discovery of widespread type I and type V CRISPR-Cas inhibitors von Marino, Nicole D, Zhang, Jenny Y, Borges, Adair L, Sousa, Alexander A, Leon, Lina M, Rauch, Benjamin J, Walton, Russell T, Berry, Joel D, Joung, J Keith, Kleinstiver, Benjamin P, Bondy-Denomy, Joseph

Volltext

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss von György, Bence, Nist-Lund, Carl, Pan, Bifeng, Asai, Yukako, Karavitaki, K. Domenica, Kleinstiver, Benjamin P., Garcia, Sara P., Zaborowski, Mikołaj P., Solanes, Paola, Spataro, Sofia, Schneider, Bernard L., Joung, J. Keith, Géléoc, Gwenaëlle S. G., Holt, Jeffrey R., Corey, David P.

Volltext

High levels of AAV vector integration into CRISPR-induced DNA breaks von Hanlon, Killian S., Kleinstiver, Benjamin P., Garcia, Sara P., Zaborowski, Mikołaj P., Volak, Adrienn, Spirig, Stefan E., Muller, Alissa, Sousa, Alexander A., Tsai, Shengdar Q., Bengtsson, Niclas E., Lööv, Camilla, Ingelsson, Martin, Chamberlain, Jeffrey S., Corey, David P., Aryee, Martin J., Joung, J. Keith, Breakefield, Xandra O., Maguire, Casey A., György, Bence

Volltext

Recent Advances in Double-Strand Break-Free Kilobase-Scale Genome Editing Technologies von Tou, Connor J., Kleinstiver, Benjamin P.

Volltext

Engineered CRISPR-Cas9 nucleases with altered PAM specificities von Kleinstiver, Benjamin P., Prew, Michelle S., Tsai, Shengdar Q., Topkar, Ved V., Nguyen, Nhu T., Zheng, Zongli, Gonzales, Andrew P. W., Li, Zhuyun, Peterson, Randall T., Yeh, Jing-Ruey Joanna, Aryee, Martin J., Joung, J. Keith

Volltext

Activities and specificities of CRISPR/Cas9 and Cas12a nucleases for targeted mutagenesis in maize von Lee, Keunsub, Zhang, Yingxiao, Kleinstiver, Benjamin P., Guo, Jimmy A., Aryee, Martin J., Miller, Jonah, Malzahn, Aimee, Zarecor, Scott, Lawrence‐Dill, Carolyn J., Joung, J. Keith, Qi, Yiping, Wang, Kan

Volltext

Programmable RNA-guided enzymes for next-generation genome editing von Tou, Connor J., Kleinstiver, Benjamin P.

Volltext

Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo von Tao, Yong, Lamas, Veronica, Du, Wan, Zhu, Wenliang, Li, Yiran, Whittaker, Madelynn N., Zuris, John A., Thompson, David B., Rameshbabu, Arun Prabhu, Shu, Yilai, Gao, Xue, Hu, Johnny H., Pei, Charles, Kong, Wei-Jia, Liu, Xuezhong, Wu, Hao, Kleinstiver, Benjamin P., Liu, David R., Chen, Zheng-Yi

Volltext

Optimization of AsCas12a for combinatorial genetic screens in human cells von DeWeirdt, Peter C., Sanson, Kendall R., Sangree, Annabel K., Hegde, Mudra, Hanna, Ruth E., Feeley, Marissa N., Griffith, Audrey L., Teng, Teng, Borys, Samantha M., Strand, Christine, Joung, J. Keith, Kleinstiver, Benjamin P., Pan, Xuewen, Huang, Alan, Doench, John G.

Volltext

Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing von Kleinstiver, Benjamin P., Sousa, Alexander A., Walton, Russell T., Tak, Y. Esther, Hsu, Jonathan Y., Clement, Kendell, Welch, Moira M., Horng, Joy E., Malagon-Lopez, Jose, Scarfò, Irene, Maus, Marcela V., Pinello, Luca, Aryee, Martin J., Joung, J. Keith

Volltext

Inducible and multiplex gene regulation using CRISPR–Cpf1-based transcription factors von Tak, Y Esther, Kleinstiver, Benjamin P, Nuñez, James K, Hsu, Jonathan Y, Horng, Joy E, Gong, Jingyi, Weissman, Jonathan S, Joung, J Keith

Volltext

Making the cut with PAMless CRISPR-Cas enzymes von Christie, Kathleen A., Kleinstiver, Benjamin P.

Volltext