Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2 von Knutson, Sarah K., Warholic, Natalie M., Wigle, Tim J., Klaus, Christine R., Allain, Christina J., Raimondi, Alejandra, Scott, Margaret Porter, Chesworth, Richard, Moyer, Mikel P., Copeland, Robert A., Richon, Victoria M., Pollock, Roy M., Kuntz, Kevin W., Keilhack, Heike

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Potent inhibition of DOT1L as treatment of MLL-fusion leukemia von Daigle, Scott R., Olhava, Edward J., Therkelsen, Carly A., Basavapathruni, Aravind, Jin, Lei, Boriack-Sjodin, P. Ann, Allain, Christina J., Klaus, Christine R., Raimondi, Alejandra, Scott, Margaret Porter, Waters, Nigel J., Chesworth, Richard, Moyer, Mikel P., Copeland, Robert A., Richon, Victoria M., Pollock, Roy M.

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Exploring the Reservoir Hosts of Tick-Borne Encephalitis Virus von Michelitsch, Anna, Wernike, Kerstin, Klaus, Christine, Dobler, Gerhard, Beer, Martin

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Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma von Knutson, Sarah K, Kawano, Satoshi, Minoshima, Yukinori, Warholic, Natalie M, Huang, Kuan-Chun, Xiao, Yonghong, Kadowaki, Tadashi, Uesugi, Mai, Kuznetsov, Galina, Kumar, Namita, Wigle, Tim J, Klaus, Christine R, Allain, Christina J, Raimondi, Alejandra, Waters, Nigel J, Smith, Jesse J, Porter-Scott, Margaret, Chesworth, Richard, Moyer, Mikel P, Copeland, Robert A, Richon, Victoria M, Uenaka, Toshimitsu, Pollock, Roy M, Kuntz, Kevin W, Yokoi, Akira, Keilhack, Heike

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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells von Knutson, Sarah K, Wigle, Tim J, Warholic, Natalie M, Sneeringer, Christopher J, Allain, Christina J, Klaus, Christine R, Sacks, Joelle D, Raimondi, Alejandra, Majer, Christina R, Song, Jeffrey, Scott, Margaret Porter, Jin, Lei, Smith, Jesse J, Olhava, Edward J, Chesworth, Richard, Moyer, Mikel P, Richon, Victoria M, Copeland, Robert A, Keilhack, Heike, Pollock, Roy M, Kuntz, Kevin W

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Control of Innate Immunity by Sialic Acids in the Nervous Tissue von Liao, Huan, Klaus, Christine, Neumann, Harald

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Initial testing (stage 1) of tazemetostat (EPZ‐6438), a novel EZH2 inhibitor, by the Pediatric Preclinical Testing Program von Kurmasheva, Raushan T., Sammons, Melissa, Favours, Edward, Wu, Jianwrong, Kurmashev, Dias, Cosmopoulos, Katherine, Keilhack, Heike, Klaus, Christine R., Houghton, Peter J., Smith, Malcolm A.

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TREM2 triggers microglial density and age‐related neuronal loss von Linnartz‐Gerlach, Bettina, Bodea, Liviu‐Gabriel, Klaus, Christine, Ginolhac, Aurélien, Halder, Rashi, Sinkkonen, Lasse, Walter, Jochen, Colonna, Marco, Neumann, Harald

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Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas von Knutson, Sarah K, Warholic, Natalie M, Johnston, L Danielle, Klaus, Christine R, Wigle, Tim J, Iwanowicz, Dorothy, Littlefield, Bruce A, Porter-Scott, Margaret, Smith, Jesse J, Moyer, Mikel P, Copeland, Robert A, Pollock, Roy M, Kuntz, Kevin W, Raimondi, Alejandra, Keilhack, Heike

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Whole animal matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry of ticks - Are spectra of Ixodes ricinus nymphs influenced by environmental, s... von Karger, Axel, Bettin, Barbara, Gethmann, Joern M, Klaus, Christine

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A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks von Mukherjee, Shradha, Klaus, Christine, Pricop-Jeckstadt, Mihaela, Miller, Jeremy A, Struebing, Felix L

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DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells von Klaus, Christine R, Iwanowicz, Dorothy, Johnston, Danielle, Campbell, Carly A, Smith, Jesse J, Moyer, Mikel P, Copeland, Robert A, Olhava, Edward J, Scott, Margaret Porter, Pollock, Roy M, Daigle, Scott R, Raimondi, Alejandra

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Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B‑Cell Lymphoma von Weiss, Matthew M., Zheng, Xiaozhang, Ji, Nan, Browne, Chris M., Campbell, Veronica, Chen, Dapeng, Enerson, Brad, Fei, Xue, Huang, Xin, Klaus, Christine R., Li, Haoran, Mayo, Michele, McDonald, Alice A., Paul, Atanu, Rong, Haojing, Sharma, Kirti, Shi, Yatao, Slavin, Anthony, Walther, Dirk M., Yuan, Karen, Zhang, Yi, Zhu, Xiao, Kelleher, Joe, Walker, Duncan, Mainolfi, Nello

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Discovery of KT-474a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases von Zheng, Xiaozhang, Ji, Nan, Campbell, Veronica, Slavin, Anthony, Zhu, Xiao, Chen, Dapeng, Rong, Haojing, Enerson, Brad, Mayo, Michele, Sharma, Kirti, Browne, Chris M., Klaus, Christine R., Li, Haoran, Massa, Ginny, McDonald, Alice A., Shi, Yatao, Sintchak, Mike, Skouras, Stephanie, Walther, Dirk M., Yuan, Karen, Zhang, Yi, Kelleher, Joe, Liu, Guang, Luo, Xinbo, Mainolfi, Nello, Weiss, Matthew M.

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6'-sialyllactose ameliorates the ototoxic effects of the aminoglycoside antibiotic neomycin in susceptible mice von Abou Assale, Tawfik, Kuenzel, Thomas, Schink, Tamara, Shahraz, Anahita, Neumann, Harald, Klaus, Christine

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Prevalence of tick-borne bacterial pathogens in Germany-has the situation changed after a decade? von Mertens-Scholz, Katja, Hoffmann, Bernd, Gethmann, Jörn M, Brangsch, Hanka, Pletz, Mathias W, Klaus, Christine

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Tick-borne encephalitis virus (TBEV) antibodies in animal sera - occurrence in goat flocks in Germany, longevity and ability to recall immunological information after more than six... von Klaus, Christine, Ziegler, Ute, Hoffmann, Donata, Press, Franziska, Fast, Christine, Beer, Martin

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EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity von Campbell, John E, Kuntz, Kevin W, Knutson, Sarah K, Warholic, Natalie M, Keilhack, Heike, Wigle, Tim J, Raimondi, Alejandra, Klaus, Christine R, Rioux, Nathalie, Yokoi, Akira, Kawano, Satoshi, Minoshima, Yukinori, Choi, Hyeong-Wook, Porter Scott, Margaret, Waters, Nigel J, Smith, Jesse J, Chesworth, Richard, Moyer, Mikel P, Copeland, Robert A

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In Vivo Characterization of Tick-Borne Encephalitis Virus in Bank Voles ( Myodes glareolus ) von Michelitsch, Anna, Tews, Birke Andrea, Klaus, Christine, Bestehorn-Willmann, Malena, Dobler, Gerhard, Beer, Martin, Wernike, Kerstin

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Goats as sentinel hosts for the detection of tick-borne encephalitis risk areas in the Canton of Valais, Switzerland von Rieille, Nadia, Klaus, Christine, Hoffmann, Donata, Péter, Olivier, Voordouw, Maarten J

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