CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice von Hammerschmidt, Philipp, Steculorum, Sophie M., Bandet, Cécile L., Del Río-Martín, Almudena, Steuernagel, Lukas, Kohlhaas, Vivien, Feldmann, Marvin, Varela, Luis, Majcher, Adam, Quatorze Correia, Marta, Klar, Rhena F. U., Bauder, Corinna A., Kaya, Ecem, Porniece, Marta, Biglari, Nasim, Sieben, Anna, Horvath, Tamas L., Hornemann, Thorsten, Brodesser, Susanne, Brüning, Jens C.

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Longitudinal analysis of cell-free mutated KRAS and CA 19-9 predicts survival following curative resection of pancreatic cancer von Hussung, Saskia, Akhoundova, Dilara, Hipp, Julian, Follo, Marie, Klar, Rhena F. U., Philipp, Ulrike, Scherer, Florian, von Bubnoff, Nikolas, Duyster, Justus, Boerries, Melanie, Wittel, Uwe, Fritsch, Ralph M.

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Plasma biomarkers for prediction of early tumor recurrence after resection of pancreatic ductal adenocarcinoma von Rittmann, Marie-Claire, Hussung, Saskia, Braun, Lukas M., Klar, Rhena F. U., Biesel, Esther A., Fichtner-Feigl, Stefan, Fritsch, Ralph, Wittel, Uwe A., Ruess, Dietrich A.

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Metabolic Profiling of Early and Late Recurrent Pancreatic Ductal Adenocarcinoma Using Patient-Derived Organoid Cultures von Braun, Lukas M., Lagies, Simon, Klar, Rhena F. U., Hussung, Saskia, Fritsch, Ralph M., Kammerer, Bernd, Wittel, Uwe A.

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Sensitivity and Resistance of Oncogenic RAS-Driven Tumors to Dual MEK and ERK Inhibition von Catalano, Antonella, Adlesic, Mojca, Kaltenbacher, Thorsten, Klar, Rhena F. U., Albers, Joachim, Seidel, Philipp, Brandt, Laura P., Hejhal, Tomas, Busenhart, Philipp, Roehner, Niklas, Zodel, Kyra, Fritsch, Kornelia, Wild, Peter J., Duyster, Justus, Fritsch, Ralph, Brummer, Tilman, Frew, Ian J.

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The anti-tumor agent sagopilone shows antiresorptive effects both in vitro and in vivo von Strube, A., Suominen, M. I., Rissanen, J. P., Mumberg, D., Klar, U., Halleen, J. M., Käkönen, S.-M.

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STAT3 signaling induced by the IL-6 family of cytokines modulates angiogenesis von Rapp, Julian, Jung, Malte, Klar, Rhena F U, Wolf, Julian, Arnold, Jakob, Gorka, Oliver, Groß, Olaf, Lange, Clemens, Agostini, Hansjürgen, Schlunck, Günther, Bucher, Felicitas

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Development and Clinical Validation of Discriminatory Multitarget Digital Droplet PCR Assays for the Detection of Hot Spot KRAS and NRAS Mutations in Cell-Free DNA von Hussung, Saskia, Follo, Marie, Klar, Rhena F.U., Michalczyk, Sandra, Fritsch, Kornelia, Nollmann, Friederike, Hipp, Julian, Duyster, Justus, Scherer, Florian, von Bubnoff, Nikolas, Boerries, Melanie, Wittel, Uwe, Fritsch, Ralph M.

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Subcellular Distribution of Epothilones in Human Tumor Cells von Lichtner, R. B., Rotgeri, A., Bunte, T., Buchmann, B., Hoffmann, J., Schwede, W., Skuballa, W., Klar, U.

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Improved Cellular Pharmacokinetics and Pharmacodynamics Underlie the Wide Anticancer Activity of Sagopilone von HOFFMANN, Jens, VILALE, Ilio, PANARETAKIS, Theocharis, SIEMEISTER, Gerhard, LAGE, Hermann, NANTY, Lisa, HAMMER, Stefanie, MITTELSTAEDT, Kevin, WINSEL, Sebastian, ESCHENBRENNER, Julia, CASTEDO, Maria, DEMARCHE, Carine, BUCHMANN, Bernd, KLAR, Ulrich, KROEMER, Guido, GALLUZZI, Lorenzo, SCHWEDE, Wolfgang, SENOVILLA, Laura, SKUBALLA, Werner, VIVET, Sonia, LICHTNER, Rosemarie B, VICENCIO, José M

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BRAF Δβ3-αC in-frame deletion mutants differ in their dimerization propensity, HSP90 dependence, and druggability von Lauinger, Manuel, Christen, Daniel, Klar, Rhena F. U., Roubaty, Carole, Heilig, Christoph E., Stumpe, Michael, Knox, Jennifer J., Radulovich, Nikolina, Tamblyn, Laura, Xie, Irene Y., Horak, Peter, Forschner, Andrea, Bitzer, Michael, Wittel, Uwe A., Boerries, Melanie, Ball, Claudia R., Heining, Christoph, Glimm, Hanno, Fröhlich, Martina, Hübschmann, Daniel, Gallinger, Steven, Fritsch, Ralph, Fröhling, Stefan, O’Kane, Grainne M., Dengjel, Jörn, Brummer, Tilman

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Evaluation of the BIOMIC video reader system for routine use in the clinical microbiology laboratory von Geiss, Heinrich K., Klar, Ulrich E.

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Post-mortem intake of lead in 11th century human bones and teeth studied by milli- and microbeam PIXE and RBS von Brenn, R, Haug, Ch, Klar, U, Zander, S, Alt, K.W, Jamieson, D.N, Lee, K.K, Schutkowski, H

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5009 ORAL Significant antitumour activity of the novel epothilone ZK-EPO against in vitro and in vivo models of ovarian cancer von Hammer, S, Arnold, N, Hilpert, F, Bräutigam, K, Sommer, A, Winsel, S, Klar, U, Hoffmann, J

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720 POSTER Subcellular distribution and cellular activity of the novel epothilone ZK-EPO von Winsel, S, Hammer, S, Eschenbrenner, J, Mittelstaedt, K, Buchmann, B, Schwede, W, Skuballa, W, Klar, U, Hoffmann, J

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Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors von LICHTNER, Rosemarie B, MENRAD, Andreas, SOMMER, Anette, KLAR, Ulrich, SCHNEIDER, Martin R

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Novel Time-Resolved Surface-Enhanced (Resonance) Raman Spectroscopic Technique for Studying the Dynamics of Interfacial Processes: Application to the Electron Transfer Reaction of... von Wackerbarth, Hainer, Klar, Udo, Günther, Walter, Hildebrandt, Peter

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Coordination of cytochrome bc1 complex assembly at MICOS von Zerbes, Ralf M, Colina-Tenorio, Lilia, Bohnert, Maria, von der Malsburg, Karina, Peikert, Christian D, Mehnert, Carola S, Perschil, Inge, Klar, Rhena F U, de Boer, Rinse, Kram, Anita, van der Klei, Ida, Oeljeklaus, Silke, Warscheid, Bettina, Rampelt, Heike, van der Laan, Martin

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CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice von Hammerschmidt, Philipp, Steculorum, Sophie M, Bandet, Cécile L, Del Río-Martín, Almudena, Steuernagel, Lukas, Kohlhaas, Vivien, Feldmann, Marvin, Varela, Luis, Majcher, Adam, Quatorze Correia, Marta, Klar, Rhena F U, Bauder, Corinna A, Kaya, Ecem, Porniece, Marta, Biglari, Nasim, Sieben, Anna, Horvath, Tamas L, Hornemann, Thorsten, Brodesser, Susanne, Brüning, Jens C

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New TXA2/PGH2 receptor antagonists based on the carbacyclin skeleton von Klar, U., Pletsch, A.

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