J147 Reduces tPA-Induced Brain Hemorrhage in Acute Experimental Stroke in Rats von Jin, Rong, Wang, Min, Zhong, Wei, Kissinger, Charles R, Villafranca, J Ernest, Li, Guohong

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Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex von Kissinger, Charles R, Parge, Hans E, Knighton, Daniel R, Lewis, Cristina T, Pelletier, Laura A, Tempczyk, Anna, Kalish, Vincent J, Tucker, Kathleen D, Showalter, Richard E, Moomaw, Ellen W, Gastinel, Louis N, Habuka, Noriyuki, Chen, Xinghai, Maldonado, Fausto, Barker, John E, Bacquet, Russell, Villafranca, J. Ernest

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Rapid automated molecular replacement by ­evolutionary search von Kissinger, Charles R., Gehlhaar, Daniel K., Fogel, David B.

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Intrinsically disordered protein von Dunker, A.Keith, Lawson, J.David, Brown, Celeste J, Williams, Ryan M, Romero, Pedro, Oh, Jeong S, Oldfield, Christopher J, Campen, Andrew M, Ratliff, Catherine M, Hipps, Kerry W, Ausio, Juan, Nissen, Mark S, Reeves, Raymond, Kang, ChulHee, Kissinger, Charles R, Bailey, Robert W, Griswold, Michael D, Chiu, Wah, Garner, Ethan C, Obradovic, Zoran

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Crystal Structure of Human ABAD/HSD10 with a Bound Inhibitor: Implications for Design of Alzheimer's Disease Therapeutics von Kissinger, Charles R., Rejto, Paul A., Pelletier, Laura A., Thomson, James A., Showalter, Richard E., Abreo, Melwyn A., Agree, Charles S., Margosiak, Stephen, Meng, Jerry J., Aust, Robert M., Vanderpool, Darin, Li, Bin, Tempczyk-Russell, Anna, Villafranca, J. Ernest

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Structure of hepatitis C virus IRES subdomain IIa von Zhao, Qiang, Han, Qing, Kissinger, Charles R., Hermann, Thomas, Thompson, Peggy A.

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Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase von RUEBSAM, Frank, MURPHY, Douglas E, BLAZEL, Julie K, SUN HEE KIM, YUEFEN ZHOU, QING HAN, KISSINGER, Charles R, WEBBER, Stephen E, SHOWALTER, Richard E, SHAH, Amit M, TSAN, Mei, PATEL, Rupal A, TRAN, Chinh V, THOMPSON, Peggy A, LEBRUN, Laurie A, HOU, Huiying J, KAMRAN, Ruhi, SERGEEVA, Maria V, BARTKOWSKI, Darian M, NOLAN, Thomas G, NORRIS, Daniel A, KHANDURINA, Julia, BROOKS, Jennifer, LI, Lian-Sheng, OKAMOTO, Ellen, KIRKOVSKY, Leo, JINGJING ZHAO, DRAGOVICH, Peter S, MCGUIRE, Helen M, XIANG, Alan X, ZHONGXIANG SUN, AYIDA, Benjamin K

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1' -dioxo-1' 4'-dihydro-1 λ6-benzoll 1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: Exploration of 7'-sub... von YUEFEN ZHOU, WEBBER, Stephen E, SHOWALTER, Richard E, PATEL, Rupal, BIN LI, QIANG ZHAO, QING HAN, HERMANN, Thomas, KISSINGER, Charles R, LEBRUN, Laurie, SERGEEVA, Maria V, KIRKOVSKY, Leo, MURPHY, Douglas E, LI, Lian-Sheng, DRAGOVICH, Peter S, TRAN, Chinh V, ZHONGXIANG SUN, RUEBSAM, Frank, SHAH, Amit M, TSAN, Mei

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Pyrrolo[1,2- b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase von Ruebsam, Frank, Webber, Stephen E., Tran, Martin T., Tran, Chinh V., Murphy, Douglas E., Zhao, Jingjing, Dragovich, Peter S., Kim, Sun Hee, Li, Lian-Sheng, Zhou, Yuefen, Han, Qing, Kissinger, Charles R., Showalter, Richard E., Lardy, Matthew, Shah, Amit M., Tsan, Mei, Patel, Rupal, LeBrun, Laurie A., Kamran, Ruhi, Sergeeva, Maria V., Bartkowski, Darian M., Nolan, Thomas G., Norris, Daniel A., Kirkovsky, Leo

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimizat... von Li, Lian-Sheng, Zhou, Yuefen, Murphy, Douglas E, Stankovic, Nebojsa, Zhao, Jingjing, Dragovich, Peter S, Bertolini, Thomas, Sun, Zhongxiang, Ayida, Benjamin, Tran, Chinh V, Ruebsam, Frank, Webber, Stephen E, Shah, Amit M, Tsan, Mei, Showalter, Richard E, Patel, Rupal, Lebrun, Laurie A, Bartkowski, Darian M, Nolan, Thomas G, Norris, Daniel A, Kamran, Ruhi, Brooks, Jennifer, Sergeeva, Maria V, Kirkovsky, Leo, Zhao, Qiang, Kissinger, Charles R

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1' ,4'-dihydro-1 λ6-benzoll[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2-an... von YUEFEN ZHOU, LI, Lian-Sheng, SHOWALTER, Richard E, PATEL, Rupal, QING HAN, QIANG ZHAO, HERMANN, Thomas, KISSINGER, Charles R, LEBRUN, Laurie, SERGEEVA, Maria V, DRAGOVICH, Peter S, MURPHY, Douglas E, TRAN, Chinh V, RUEBSAM, Frank, WEBBER, Stephen E, SHAH, Amit M, TSAN, Mei, AVERILL, April

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'λ6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5. Exploration of pyridazin... von DRAGOVICH, Peter S, BLAZEL, Julie K, PATEL, Rupal A, RUEBSAM, Frank, SERGEEVA, Maria V, SHAH, Amit M, SHOWALTER, Richard E, TRAN, Chinh V, TSAN, Mei, WEBBER, Stephen E, KIRKOVSKY, Leo, YUEFEN ZHOU, ELLIS, David A, QING HAN, KAMRAN, Ruhi, KISSINGER, Charles R, LEBRUN, Laurie A, LI, Lian-Sheng, MURPHY, Douglas E, NOBLE, Michael

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Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[ b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B po... von Kim, Sun Hee, Tran, Martin T., Ruebsam, Frank, Xiang, Alan X., Ayida, Benjamin, McGuire, Helen, Ellis, David, Blazel, Julie, Tran, Chinh V., Murphy, Douglas E., Webber, Stephen E., Zhou, Yuefen, Shah, Amit M., Tsan, Mei, Showalter, Richard E., Patel, Rupal, Gobbi, Alberto, LeBrun, Laurie A., Bartkowski, Darian M., Nolan, Thomas G., Norris, Daniel A., Sergeeva, Maria V., Kirkovsky, Leo, Zhao, Qiang, Han, Qing, Kissinger, Charles R.

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5,5'- and 6,6'-Dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase von ELLIS, David A, BLAZEL, Julie K, WEBBER, Stephen E, QIANG ZHAO, QING HAN, KISSINGER, Charles R, LARDY, Matthew, GOBBI, Alberto, SHOWALTER, Richard E, SHAH, Amit M, TSAN, Mei, PATEL, Rupal A, TRAN, Chinh V, LEBRUN, Laurie A, KAMRAN, Ruhi, BARTKOWSKI, Darian M, NOLAN, Thomas G, NORRIS, Daniel A, SERGEEVA, Maria V, KIRKOVSKY, Leo, RUEBSAM, Frank, MURPHY, Douglas E, LI, Lian-Sheng, JINGJING ZHAO, YUEFEN ZHOU, MCGUIRE, Helen M, XIANG, Alan X

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Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions von Kissinger, Charles R., Liu, Beishan, Martin-Blanco, Enrique, Kornberg, Thomas B., Pabo, Carl O.

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Hexahydro-pyrrolo-and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase von RUEBSAM, Frank, ZHONGXIANG SUN, PATEL, Rupal, LEBRUN, Laurie A, KAMRAN, Ruhi, SERGEEVA, Maria V, BARTKOWSKI, Darian M, NOLAN, Thomas G, NORRIS, Daniel A, KIRKOVSKY, Leo, AYIDA, Benjamin K, WEBBER, Stephen E, YUEFEN ZHOU, QIANG ZHAO, KISSINGER, Charles R, SHOWALTER, Richard E, SHAH, Amit M, TSAN, Mei

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4-(1,1-Dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase von ELLIS, David A, BLAZEL, Julie K, LI, Lian-Sheng, YUEFEN ZHOU, QING HAN, KISSINGER, Charles R, SHOWALTER, Richard E, LARDY, Matthew, SHAH, Amit M, TSAN, Mei, PATEL, Rupal, LEBRUN, Laurie A, WEBBER, Stephen E, KAMRAN, Ruhi, BARTKOWSKI, Darian M, NOLAN, Thomas G, NORRIS, Daniel A, SERGEEVA, Maria V, KIRKOVSKY, Leo, TRAN, Chinh V, DRAGOVICH, Peter S, ZHONGXIANG SUN, RUEBSAM, Frank, MCGUIRE, Helen M, XIANG, Alan X, JINGJING ZHAO

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Structural studies of the engrailed homeodomain von Clarke, Neil D., Kissinger, Charles R., Desjarlais, John, Gilliland, Gary L., Pabo, Carl O.

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Refined crystal structure of ferredoxin II from Desulfovibrio gigas at 1·7 Å von Kissinger, Charles R., Sieker, Larry C., Adman, Elinor T., Jensen, Lyle H.

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Interaction of a Novel GDP Exchange Inhibitor with the Ras Protein von Ganguly, Ashit K, Wang, Yu-Sen, Pramanik, Birendra N, Doll, Ronald J, Snow, Mark E, Taveras, Arthur G, Remiszewski, Stacy, Cesarz, David, del Rosario, J, Vibulbhan, Bancha, Brown, Joan E, Kirschmeier, Paul, Huang, Eric C, Heimark, Larry, Tsarbopoulos, Anthony, Girijavallabhan, Viyyoor M, Aust, Robert M, Brown, Edward L, DeLisle, Dorothy M, Fuhrman, Shella A, Hendrickson, Thomas F, Kissinger, Charles R, Love, Robert A, Sisson, Wess A, Villafranca, J. Ernest, Webber, Steve E

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