Aneuploidy in children with relapsed B‐cell precursor acute lymphoblastic leukaemia: clinical importance of detecting a hypodiploid origin of relapse von Groeneveld‐Krentz, Stefanie, Schroeder, Michael P., Reiter, Michael, Pogodzinski, Malwine J., Pimentel‐Gutiérrez, Helia J., Vagkopoulou, Renia, Hof, Jana, Chen‐Santel, Christiane, Nebral, Karin, Bradtke, Jutta, Türkmen, Seval, Baldus, Claudia D., Gattenlöhner, Stefan, Haas, Oskar A., Stackelberg, Arend, Karawajew, Leonid, Eckert, Cornelia, Kirschner‐Schwabe, Renate

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Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition von Irving, Julie, Matheson, Elizabeth, Minto, Lynne, Blair, Helen, Case, Marian, Halsey, Christina, Swidenbank, Isabella, Ponthan, Frida, Kirschner-Schwabe, Renate, Groeneveld-Krentz, Stefanie, Hof, Jana, Allan, James, Harrison, Christine, Vormoor, Josef, von Stackelberg, Arend, Eckert, Cornelia

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Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL von Tzoneva, Gannie, Perez-Garcia, Arianne, Carpenter, Zachary, Khiabanian, Hossein, Tosello, Valeria, Allegretta, Maddalena, Paietta, Elisabeth, Racevskis, Janis, Rowe, Jacob M, Tallman, Martin S, Paganin, Maddalena, Basso, Giuseppe, Hof, Jana, Kirschner-Schwabe, Renate, Palomero, Teresa, Rabadan, Raul, Ferrando, Adolfo

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Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia von Oshima, Koichi, Khiabanian, Hossein, da Silva-Almeida, Ana C., Tzoneva, Gannie, Abate, Francesco, Ambesi-Impiombato, Alberto, Sanchez-Martin, Marta, Carpenter, Zachary, Penson, Alex, Perez-Garcia, Arianne, Eckert, Cornelia, Nicolas, Concepción, Balbin, Milagros, Sulis, Maria Luisa, Kato, Motohiro, Koh, Katsuyoshi, Paganin, Maddalena, Basso, Giuseppe, Gastier-Foster, Julie M., Devidas, Meenakshi, Loh, Mignon L., Kirschner-Schwabe, Renate, Palomero, Teresa, Rabadan, Raul, Ferrando, Adolfo A.

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Negative feedback–defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL von Li, Benshang, Li, Hui, Bai, Yun, Kirschner-Schwabe, Renate, Yang, Jun J, Chen, Yao, Lu, Gang, Tzoneva, Gannie, Ma, Xiaotu, Wu, Tongmin, Li, Wenjing, Lu, Haisong, Ding, Lixia, Liang, Huanhuan, Huang, Xiaohang, Yang, Minjun, Jin, Lei, Kang, Hui, Chen, Shuting, Du, Alicia, Shen, Shuhong, Ding, Jianping, Chen, Hongzhuan, Chen, Jing, von Stackelberg, Arend, Gu, Longjun, Zhang, Jinghui, Ferrando, Adolfo, Tang, Jingyan, Wang, Shengyue, Zhou, Bin-Bing S

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Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia von Dieck, Chelsea L., Tzoneva, Gannie, Forouhar, Farhad, Carpenter, Zachary, Ambesi-Impiombato, Alberto, Sánchez-Martín, Marta, Kirschner-Schwabe, Renate, Lew, Scott, Seetharaman, Jayaraman, Tong, Liang, Ferrando, Adolfo A.

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P333: SUBCLONAL AND CLONAL VARIANTS IN TP53 AND KRAS COMBINED WITH POOR TREATMENT RESPONSE IDENTIFY A SUBGROUP OF ULTRA‐HIGH‐RISK PATIENTS OF PEDIATRIC T‐LYMPHOBLASTIC LEUKEMIA (T‐... von Kempter, Tamara, Richter‐Pechanska, Paulina, Michel, Katarzyna, Rausch, Tobias, Erarslan‐Uysal, Büşra, Eckert, Cornelia, Zimmermann, Martin, Stanulla, Martin, Schrappe, Martin, Cario, Gunnar, Kirschner‐Schwabe, Renate, Koehrer, Stefan, Korbel, Jan, Kunz, Joachim, Kulozik, Andreas E

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Mutations and Deletions of the TP53 Gene Predict Nonresponse to Treatment and Poor Outcome in First Relapse of Childhood Acute Lymphoblastic Leukemia von HOF, Jana, KRENTZ, Stefanie, STACKELBERG, Arend Von, HAGEMEIER, Christian, ECKERT, Cornelia, KIRSCHNER-SCHWABE, Renate, SCHEWICK, Claudia Van, KÖRNER, Gabriele, SHALAPOUR, Shabnam, RHEIN, Peter, KARAWAJEW, Leonid, LUDWIG, Wolf-Dieter, SEEGER, Karl, HENZE, Günter

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Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism von Wellmann, Sven, Bührer, Christoph, Moderegger, Eva, Zelmer, Andrea, Kirschner, Renate, Koehne, Petra, Fujita, Jun, Seeger, Karl

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The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse von Bandapalli, Obul R, Schuessele, Stephanie, Kunz, Joachim B, Rausch, Tobias, Stütz, Adrian M, Tal, Noa, Geron, Ifat, Gershman, Nava, Izraeli, Shai, Eilers, Juliane, Vaezipour, Nina, Kirschner-Schwabe, Renate, Hof, Jana, von Stackelberg, Arend, Schrappe, Martin, Stanulla, Martin, Zimmermann, Martin, Koehler, Rolf, Avigad, Smadar, Handgretinger, Rupert, Frismantas, Viktoras, Bourquin, Jean Pierre, Bornhauser, Beat, Korbel, Jan O, Muckenthaler, Martina U, Kulozik, Andreas E

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Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation von Kunz, Joachim B, Rausch, Tobias, Bandapalli, Obul R, Eilers, Juliane, Pechanska, Paulina, Schuessele, Stephanie, Assenov, Yassen, Stütz, Adrian M, Kirschner-Schwabe, Renate, Hof, Jana, Eckert, Cornelia, von Stackelberg, Arend, Schrappe, Martin, Stanulla, Martin, Koehler, Rolf, Avigad, Smadar, Elitzur, Sarah, Handgretinger, Rupert, Benes, Vladimir, Weischenfeldt, Joachim, Korbel, Jan O, Muckenthaler, Martina U, Kulozik, Andreas E

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Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures von Schroeder, Michael P., Bastian, Lorenz, Eckert, Cornelia, Gökbuget, Nicola, James, Alva Rani, Tanchez, Jutta Ortiz, Schlee, Cornelia, Isaakidis, Konstandina, Häupl, Björn, Baum, Katharina, Migueles Lozano, Oscar Arturo, Kouidri, Khouloud, Pan, Kuan-Ting, Urlaub, Henning, Schwartz, Stefan, Burmeister, Thomas, von Stackelberg, Arend, Hoelzer, Dieter, Pfeiffer, Heike, Rieger, Michael A., Göllner, Stefanie, Oellerich, Thomas, Horstman, Martin, Schrappe, Martin, Wolf, Jana, Kirschner-Schwabe, Renate, Brüggemann, Monika, Müller-Tidow, Carsten, Serve, Hubert, Neumann, Martin, Baldus, Claudia D.

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Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia von James, Alva Rani, Schroeder, Michael P, Neumann, Martin, Bastian, Lorenz, Eckert, Cornelia, Gökbuget, Nicola, Tanchez, Jutta Ortiz, Schlee, Cornelia, Isaakidis, Konstandina, Schwartz, Stefan, Burmeister, Thomas, von Stackelberg, Arend, Rieger, Michael A, Göllner, Stefanie, Horstman, Martin, Schrappe, Martin, Kirschner-Schwabe, Renate, Brüggemann, Monika, Müller-Tidow, Carsten, Serve, Hubert, Akalin, Altuna, Baldus, Claudia D

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High VLA-4 expression is associated with adverse outcome and distinct gene expression changes in childhood B-cell precursor acute lymphoblastic leukemia at first relapse von SHALAPOUR, Shabnam, HOF, Jana, KIRSCHNER-SCHWABE, Renate, BASTIAN, Lorenz, ECKERT, Cornelia, PRADA, Javier, HENZE, Günter, VON STACKELBERG, Arend, SEEGER, Karl

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Clinical and genetic characteristics of children with acute lymphoblastic leukemia and Li–Fraumeni syndrome von Winter, Greta, Kirschner-Schwabe, Renate, Groeneveld-Krentz, Stefanie, Escherich, Gabriele, Möricke, Anja, von Stackelberg, Arend, Stanulla, Martin, Bailey, Simon, Richter, Lisa, Steinemann, Doris, Ripperger, Tim, Escudero, Adela, Farah, Roula, Lohi, Olli, Wadt, Karin, Jongmans, Marjolijn, van Engelen, Nienke, Eckert, Cornelia, Kratz, Christian Peter

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Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse von Yang, Fan, Brady, Samuel W, Tang, Chao, Sun, Huiying, Du, Lijuan, Barz, Malwine J, Ma, Xiaotu, Chen, Yao, Fang, Houshun, Li, Xiaomeng, Kolekar, Pandurang, Pathak, Omkar, Cai, Jiaoyang, Ding, Lixia, Wang, Tianyi, von Stackelberg, Arend, Shen, Shuhong, Eckert, Cornelia, Klco, Jeffery M, Chen, Hongzhuan, Duan, Caiwen, Liu, Yu, Li, Hui, Li, Benshang, Kirschner-Schwabe, Renate, Zhang, Jinghui, Zhou, Bin-Bing S

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The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia von Xu, Yan, Fang, Houshun, Chen, Yao, Tang, Yabin, Sun, Huiying, Kong, Ziqing, Yang, Fan, Kirschner-Schwabe, Renate, Zhu, Liang, Toker, Alex, Xiao, Ning, Zhou, Bin-Bing S., Li, Hui

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Positional cloning of the gene for X-linked retinitis pigmentosa 2 von Schwahn, Uwe, Lenzner, Steffen, Dong, Juan, Feil, Silke, Hinzmann, Bernd, van Duijnhoven, Gerard, Kirschner, Renate, Hemberger, Myriam, Bergen, Arthur A.B., Rosenberg, Thomas, Pinckers, Alfred J.L.G., Fundele, Reinald, Rosenthal, André, Cremers, Frans P.M., Ropers, H.-Hilger, Berger, Wolfgang

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NOTCH1 mutation, TP53 alteration and myeloid antigen expression predict outcome heterogeneity in children with first relapse of T-cell acute lymphoblastic leukemia von Hof, Jana, Kox, Corinne, Groeneveld-Krentz, Stefanie, Bandapalli, Obul R, Karawajew, Leonid, Schedel, Katharina, Kunz, Joachim B, Eckert, Cornelia, Ludwig, Wolf-Dieter, Ratei, Richard, Rhein, Peter, Henze, Günter, Muckenthaler, Martina U, Kulozik, Andreas E, von Stackelberg, Arend, Kirschner-Schwabe, Renate

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Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia von Meissner, Barbara, Bartram, Thies, Eckert, Cornelia, Trka, Jan, Panzer-Grümayer, Renate, Hermanova, Ivana, Ellinghaus, Eva, Franke, Andre, Möricke, Anja, Schrauder, André, Teigler-Schlegel, Andrea, Dörge, Petra, von Stackelberg, Arend, Basso, Giuseppe, Bartram, Claus R, Kirschner-Schwabe, Renate, Bornhäuser, Beat, Bourquin, Jean-Pierre, Cazzaniga, Giovanni, Hauer, Julia, Attarbaschi, Andishe, Izraeli, Shai, Zaliova, Marketa, Cario, Gunnar, Zimmermann, Martin, Avigad, Smadar, Sokalska-Duhme, Magdalena, Metzler, Markus, Schrappe, Martin, Koehler, Rolf, Te Kronnie, Geertruy, Stanulla, Martin

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