Dynamic balance of pro‐ and anti‐inflammatory signals controls disease and limits pathology von Cicchese, Joseph M., Evans, Stephanie, Hult, Caitlin, Joslyn, Louis R., Wessler, Timothy, Millar, Jess A., Marino, Simeone, Cilfone, Nicholas A., Mattila, Joshua T., Linderman, Jennifer J., Kirschner, Denise E.

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Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation von Evans, Stephanie, Butler, J. Russell, Mattila, Joshua T., Kirschner, Denise E.

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Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization von Gideon, Hannah Priyadarshini, Phuah, JiaYao, Myers, Amy J, Bryson, Bryan D, Rodgers, Mark A, Coleman, M Teresa, Maiello, Pauline, Rutledge, Tara, Marino, Simeone, Fortune, Sarah M, Kirschner, Denise E, Lin, Philana Ling, Flynn, JoAnne L

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Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms von Mattila, Joshua T, Ojo, Olabisi O, Kepka-Lenhart, Diane, Marino, Simeone, Kim, Jin Hee, Eum, Seok Yong, Via, Laura E, Barry, 3rd, Clifton E, Klein, Edwin, Kirschner, Denise E, Morris, Jr, Sidney M, Lin, Philana Ling, Flynn, Joanne L

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Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection von Marino, Simeone, Cilfone, Nicholas A, Mattila, Joshua T, Linderman, Jennifer J, Flynn, JoAnne L, Kirschner, Denise E

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Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens von Budak, Maral, Cicchese, Joseph M, Maiello, Pauline, Borish, H Jacob, White, Alexander G, Chishti, Harris B, Tomko, Jaime, Frye, L James, Fillmore, Daniel, Kracinovsky, Kara, Sakal, Jennifer, Scanga, Charles A, Lin, Philana Ling, Dartois, Véronique, Linderman, Jennifer J, Flynn, JoAnne L, Kirschner, Denise E

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Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach von Pienaar, Elsje, Sarathy, Jansy, Prideaux, Brendan, Dietzold, Jillian, Dartois, Véronique, Kirschner, Denise E, Linderman, Jennifer J

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Concomitant immunity to M. tuberculosis infection von Joslyn, Louis R., Flynn, JoAnne L., Kirschner, Denise E., Linderman, Jennifer J.

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Neutrophil Dynamics Affect Mycobacterium tuberculosis Granuloma Outcomes and Dissemination von Hult, Caitlin, Mattila, Joshua T., Gideon, Hannah P., Linderman, Jennifer J., Kirschner, Denise E.

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Multi-scale modeling predicts a balance of tumor necrosis factor-α and interleukin-10 controls the granuloma environment during Mycobacterium tuberculosis infection von Cilfone, Nicholas A, Perry, Cory R, Kirschner, Denise E, Linderman, Jennifer J

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Emergence and selection of isoniazid and rifampin resistance in tuberculosis granulomas von Pienaar, Elsje, Linderman, Jennifer J, Kirschner, Denise E

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Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo von Repasy, Teresa, Lee, Jinhee, Marino, Simeone, Martinez, Nuria, Kirschner, Denise E, Hendricks, Gregory, Baker, Stephen, Wilson, Andrew A, Kotton, Darrell N, Kornfeld, Hardy

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A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination von Wessler, Timothy, Joslyn, Louis R., Borish, H. Jacob, Gideon, Hannah P., Flynn, JoAnne L., Kirschner, Denise E., Linderman, Jennifer J.

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Differential risk of tuberculosis reactivation among anti-TNF therapies is due to drug binding kinetics and permeability von Fallahi-Sichani, Mohammad, Flynn, JoAnne L, Linderman, Jennifer J, Kirschner, Denise E

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Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model von Warsinske, Hayley C, Pienaar, Elsje, Linderman, Jennifer J, Mattila, Joshua T, Kirschner, Denise E

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Calibration methods to fit parameters within complex biological models von Nanda, Pariksheet, Kirschner, Denise E

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Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas von Cicchese, Joseph M., Dartois, Veronique, Kirschner, Denise E., Linderman, Jennifer J.

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Computational and Empirical Studies Predict Mycobacterium tuberculosis-Specific T Cells as a Biomarker for Infection Outcome von Marino, Simeone, Gideon, Hannah P, Gong, Chang, Mankad, Shawn, McCrone, John T, Lin, Philana Ling, Linderman, Jennifer J, Flynn, JoAnne L, Kirschner, Denise E

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NF-κB Signaling Dynamics Play a Key Role in Infection Control in Tuberculosis von Fallahi-Sichani, Mohammad, Kirschner, Denise E, Linderman, Jennifer J

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T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques von Grant, Nicole L., Maiello, Pauline, Klein, Edwin, Lin, Philana Ling, Borish, H. Jacob, Tomko, Jaime, Frye, L. James, White, Alexander G., Kirschner, Denise E., Mattila, Joshua T., Flynn, JoAnne L.

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