Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma von Iorgulescu, J Bryan, Gokhale, Prafulla C, Speranza, Maria C, Eschle, Benjamin K, Poitras, Michael J, Wilkens, Margaret K, Soroko, Kara M, Chhoeu, Chhayheng, Knott, Aine, Gao, Yan, Lim-Fat, Mary Jane, Baker, Gregory J, Bonal, Dennis M, Nguyen, Quang-Dé, Grant, Gareth R L, Ligon, Keith L, Sorger, Peter K, Chiocca, E Antonio, Anderson, Ana C, Kirschmeier, Paul T, Sharpe, Arlene H, Freeman, Gordon J, Reardon, David A

Volltext

The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition von Parmar, Kalindi, Kochupurakkal, Bose S, Lazaro, Jean-Bernard, Wang, Zhigang C, Palakurthi, Sangeetha, Kirschmeier, Paul T, Yang, Chunyu, Sambel, Larissa A, Färkkilä, Anniina, Reznichenko, Elizaveta, Reavis, Hunter D, Dunn, Connor E, Zou, Lee, Do, Khanh T, Konstantinopoulos, Panagiotis A, Matulonis, Ursula A, Liu, Joyce F, D'Andrea, Alan D, Shapiro, Geoffrey I

Volltext

Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer von Kitajima, Shunsuke, Ivanova, Elena, Guo, Sujuan, Yoshida, Ryohei, Campisi, Marco, Sundararaman, Shriram K, Tange, Shoichiro, Mitsuishi, Yoichiro, Thai, Tran C, Masuda, Sayuri, Piel, Brandon P, Sholl, Lynette M, Kirschmeier, Paul T, Paweletz, Cloud P, Watanabe, Hideo, Yajima, Mamiko, Barbie, David A

Volltext

Noninvasive Detection of Response and Resistance in EGFR-Mutant Lung Cancer Using Quantitative Next-Generation Genotyping of Cell-Free Plasma DNA von OXNARD, Geoffrey R, PAWELETZ, Cloud P, JÄNNE, Pasi A, YANAN KUANG, MACH, Stacy L, O'CONNELL, Allison, MESSINEO, Melissa M, LUKE, Jason J, BUTANEY, Mohit, KIRSCHMEIER, Paul, JACKMAN, David M

Volltext

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway von Kurppa, Kari J., Liu, Yao, To, Ciric, Zhang, Tinghu, Fan, Mengyang, Vajdi, Amir, Knelson, Erik H., Xie, Yingtian, Lim, Klothilda, Cejas, Paloma, Portell, Andrew, Lizotte, Patrick H., Ficarro, Scott B., Li, Shuai, Chen, Ting, Haikala, Heidi M., Wang, Haiyun, Bahcall, Magda, Gao, Yang, Shalhout, Sophia, Boettcher, Steffen, Shin, Bo Hee, Thai, Tran, Wilkens, Margaret K., Tillgren, Michelle L., Mushajiang, Mierzhati, Xu, Man, Choi, Jihyun, Bertram, Arrien A., Ebert, Benjamin L., Beroukhim, Rameen, Bandopadhayay, Pratiti, Awad, Mark M., Gokhale, Prafulla C., Kirschmeier, Paul T., Marto, Jarrod A., Camargo, Fernando D., Haq, Rizwan, Paweletz, Cloud P., Wong, Kwok-Kin, Barbie, David A., Long, Henry W., Gray, Nathanael S., Jänne, Pasi A.

Volltext

Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics von Liu, Joyce F, Palakurthi, Sangeetha, Zeng, Qing, Zhou, Shan, Ivanova, Elena, Huang, Wei, Zervantonakis, Ioannis K, Selfors, Laura M, Shen, Yiping, Pritchard, Colin C, Zheng, Mei, Adleff, Vilmos, Papp, Eniko, Piao, Huiying, Novak, Marian, Fotheringham, Susan, Wulf, Gerburg M, English, Jessie, Kirschmeier, Paul T, Velculescu, Victor E, Paweletz, Cloud, Mills, Gordon B, Livingston, David M, Brugge, Joan S, Matulonis, Ursula A, Drapkin, Ronny

Volltext

Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13 von Zeng, Mei, Kwiatkowski, Nicholas P, Zhang, Tinghu, Nabet, Behnam, Xu, Mousheng, Liang, Yanke, Quan, Chunshan, Wang, Jinhua, Hao, Mingfeng, Palakurthi, Sangeetha, Zhou, Shan, Zeng, Qing, Kirschmeier, Paul T, Meghani, Khyati, Leggett, Alan L, Qi, Jun, Shapiro, Geoffrey I, Liu, Joyce F, Matulonis, Ursula A, Lin, Charles Y, Konstantinopoulos, Panagiotis A, Gray, Nathanael S

Volltext

EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody-Drug Conjugate HER3-DXd von Haikala, Heidi M, Lopez, Timothy, Köhler, Jens, Eser, Pinar O, Xu, Man, Zeng, Qing, Teceno, Tyler J, Ngo, Kenneth, Zhao, Yutong, Ivanova, Elena V, Bertram, Arrien A, Leeper, Brittaney A, Chambers, Emily S, Adeni, Anika E, Taus, Luke J, Kuraguchi, Mari, Kirschmeier, Paul T, Yu, Channing, Shiose, Yoshinobu, Kamai, Yasuki, Qiu, Yang, Paweletz, Cloud P, Gokhale, Prafulla C, Jänne, Pasi A

Volltext

Amplification of Wild-type KRAS Imparts Resistance to Crizotinib in MET Exon 14 Mutant Non-Small Cell Lung Cancer von Bahcall, Magda, Awad, Mark M, Sholl, Lynette M, Wilson, Frederick H, Xu, Man, Wang, Stephen, Palakurthi, Sangeetha, Choi, Jihyun, Ivanova, Elena V, Leonardi, Giulia C, Ulrich, Bryan C, Paweletz, Cloud P, Kirschmeier, Paul T, Watanabe, Masayuki, Baba, Hideo, Nishino, Mizuki, Nagy, Rebecca J, Lanman, Richard B, Capelletti, Marzia, Chambers, Emily S, Redig, Amanda J, VanderLaan, Paul A, Costa, Daniel B, Imamura, Yu, Jänne, Pasi A

Volltext

The Combined Effect of FGFR Inhibition and PD-1 Blockade Promotes Tumor-Intrinsic Induction of Antitumor Immunity von Palakurthi, Sangeetha, Kuraguchi, Mari, Zacharek, Sima J, Zudaire, Enrique, Huang, Wei, Bonal, Dennis M, Liu, Jeffrey, Dhaneshwar, Abha, DePeaux, Kristin, Gowaski, Martha R, Bailey, Dyane, Regan, Samuel N, Ivanova, Elena, Ferrante, Catherine, English, Jessie M, Khosla, Aditya, Beck, Andrew H, Rytlewski, Julie A, Sanders, Catherine, Laquerre, Sylvie, Bittinger, Mark A, Kirschmeier, Paul T, Packman, Kathryn, Janne, Pasi A, Moy, Christopher, Wong, Kwok-Kin, Verona, Raluca I, Lorenzi, Matthew V

Volltext

Bias-Corrected Targeted Next-Generation Sequencing for Rapid, Multiplexed Detection of Actionable Alterations in Cell-Free DNA from Advanced Lung Cancer Patients von Paweletz, Cloud P, Sacher, Adrian G, Raymond, Chris K, Alden, Ryan S, O'Connell, Allison, Mach, Stacy L, Kuang, Yanan, Gandhi, Leena, Kirschmeier, Paul, English, Jessie M, Lim, Lee P, Jänne, Pasi A, Oxnard, Geoffrey R

Volltext

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS von Kitajima, Shunsuke, Asahina, Hajime, Chen, Ting, Guo, Sujuan, Quiceno, Laura Gutierrez, Cavanaugh, Jillian D., Merlino, Ashley A., Tange, Shoichiro, Terai, Hideki, Kim, Jong Wook, Wang, Xiaoen, Zhou, Shan, Xu, Man, Wang, Stephen, Zhu, Zehua, Thai, Tran C., Takahashi, Chiaki, Wang, Yujin, Neve, Richard, Stinson, Susanna, Tamayo, Pablo, Watanabe, Hideo, Kirschmeier, Paul T., Wong, Kwok-Kin, Barbie, David A.

Volltext

Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor von Parry, David, Guzi, Timothy, Shanahan, Frances, Davis, Nicole, Prabhavalkar, Deepa, Wiswell, Derek, Seghezzi, Wolfgang, Paruch, Kamil, Dwyer, Michael P, Doll, Ronald, Nomeir, Amin, Windsor, William, Fischmann, Thierry, Wang, Yaolin, Oft, Martin, Chen, Taiying, Kirschmeier, Paul, Lees, Emma M

Volltext

Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade von Sehgal, Kartik, Portell, Andrew, Ivanova, Elena V, Lizotte, Patrick H, Mahadevan, Navin R, Greene, Jonathan R, Vajdi, Amir, Gurjao, Carino, Teceno, Tyler, Taus, Luke J, Thai, Tran C, Kitajima, Shunsuke, Liu, Derek, Tani, Tetsuo, Noureddine, Moataz, Lau, Christie J, Kirschmeier, Paul T, Liu, David, Giannakis, Marios, Jenkins, Russell W, Gokhale, Prafulla C, Goldoni, Silvia, Pinzon-Ortiz, Maria, Hastings, William D, Hammerman, Peter S, Miret, Juan J, Paweletz, Cloud P, Barbie, David A

Volltext

Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells von Bhanot, H, Reddy, M M, Nonami, A, Weisberg, E L, Bonal, D, Kirschmeier, P T, Salgia, S, Podar, K, Galinsky, I, Chowdary, T K, Neuberg, D, Tonon, G, Stone, R M, Asara, J, Griffin, J D, Sattler, M

Volltext

Combination of Type I and Type II MET Tyrosine Kinase Inhibitors as Therapeutic Approach to Prevent Resistance von Bahcall, Magda, Paweletz, Cloud P, Kuang, Yanan, Taus, Luke J, Sim, Taebo, Kim, Nam Doo, Dholakia, Kshiti H, Lau, Christie J, Gokhale, Prafulla C, Chopade, Pratik R, Hong, Fangxin, Wei, Zihan, Köhler, Jens, Kirschmeier, Paul T, Guo, Jiannan, Guo, Sujuan, Wang, Stephen, Jänne, Pasi A

Volltext

Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity von Miret, Juan J, Kirschmeier, Paul, Koyama, Shohei, Zhu, Mingrui, Li, Yvonne Y, Naito, Yujiro, Wu, Min, Malladi, Venkat S, Huang, Wei, Walker, William, Palakurthi, Sangeetha, Dranoff, Glenn, Hammerman, Peter S, Pecot, Chad V, Wong, Kwok-Kin, Akbay, Esra A

Volltext

Rho Family GTPase Modification and Dependence on CAAX Motif-signaled Posttranslational Modification von Roberts, Patrick J., Mitin, Natalia, Keller, Patricia J., Chenette, Emily J., Madigan, James P., Currin, Rachel O., Cox, Adrienne D., Wilson, Oswald, Kirschmeier, Paul, Der, Channing J.

Volltext

A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing von Lizotte, Patrick H, Hong, Ruey-Long, Luster, Troy A, Cavanaugh, Megan E, Taus, Luke J, Wang, Stephen, Dhaneshwar, Abha, Mayman, Naomi, Yang, Aaron, Kulkarni, Meghana, Badalucco, Lauren, Fitzpatrick, Erica, Kao, Hsiang-Fong, Kuraguchi, Mari, Bittinger, Mark, Kirschmeier, Paul T, Gray, Nathanael S, Barbie, David A, Jänne, Pasi A

Volltext

Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C von Kedves, Alexia T, Gleim, Scott, Liang, Xiaoyou, Bonal, Dennis M, Sigoillot, Frederic, Harbinski, Fred, Sanghavi, Sneha, Benander, Christina, George, Elizabeth, Gokhale, Prafulla C, Nguyen, Quang-De, Kirschmeier, Paul T, Distel, Robert J, Jenkins, Jeremy, Goldberg, Michael S, Forrester, William C

Volltext