Rapid prediction of key residues for foldability by machine learning model enables the design of highly functional libraries with hyperstable constrained peptide scaffolds von Cai, Fei, Wei, Yuehua, Kirchhofer, Daniel, Chang, Andrew, Zhang, Yingnan

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Disulfide-constrained peptide scaffolds enable a robust peptide-therapeutic discovery platform von Zhou, Lijuan, Cai, Fei, Li, Yanjie, Gao, Xinxin, Wei, Yuehua, Fedorova, Anna, Kirchhofer, Daniel, Hannoush, Rami N, Zhang, Yingnan

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Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis von Witkowski, Marco, Witkowski, Mario, Friebel, Julian, Buffa, Jennifer A, Li, Xinmin S, Wang, Zeneng, Sangwan, Naseer, Li, Lin, DiDonato, Joseph A, Tizian, Caroline, Haghikia, Arash, Kirchhofer, Daniel, Mach, François, Räber, Lorenz, Matter, Christian M, Tang, W H Wilson, Landmesser, Ulf, Lüscher, Thomas F, Rauch, Ursula, Hazen, Stanley L

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Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes von Hewings, David S., Heideker, Johanna, Ma, Taylur P., AhYoung, Andrew P., El Oualid, Farid, Amore, Alessia, Costakes, Gregory T., Kirchhofer, Daniel, Brasher, Bradley, Pillow, Thomas, Popovych, Nataliya, Maurer, Till, Schwerdtfeger, Carsten, Forrest, William F., Yu, Kebing, Flygare, John, Bogyo, Matthew, Wertz, Ingrid E.

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Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists von Zhang, Yingnan, Ultsch, Mark, Skelton, Nicholas J, Burdick, Daniel J, Beresini, Maureen H, Li, Wei, Kong-Beltran, Monica, Peterson, Andrew, Quinn, John, Chiu, Cecilia, Wu, Yan, Shia, Steven, Moran, Paul, Di Lello, Paola, Eigenbrot, Charles, Kirchhofer, Daniel

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Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region von Li, Yanjie, Wei, Yuehua, Ultsch, Mark, Li, Wei, Tang, Wanjian, Tombling, Benjamin, Gao, Xinxin, Dimitrova, Yoana, Gampe, Christian, Fuhrmann, Jakob, Zhang, Yingnan, Hannoush, Rami N., Kirchhofer, Daniel

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Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets von Hitchcock, Jessica R, Cook, Charlotte N, Bobat, Saeeda, Ross, Ewan A, Flores-Langarica, Adriana, Lowe, Kate L, Khan, Mahmood, Dominguez-Medina, C Coral, Lax, Sian, Carvalho-Gaspar, Manuela, Hubscher, Stefan, Rainger, G Ed, Cobbold, Mark, Buckley, Christopher D, Mitchell, Tim J, Mitchell, Andrea, Jones, Nick D, Van Rooijen, N, Kirchhofer, Daniel, Henderson, Ian R, Adams, David H, Watson, Steve P, Cunningham, Adam F

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Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody–induced fetal injury von Redecha, Patricia, Tilley, Rachel, Tencati, Michael, Salmon, Jane E., Kirchhofer, Daniel, Mackman, Nigel, Girardi, Guillermina

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Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy von Tom, Irene, Pham, Victoria C., Katschke, Kenneth J., Li, Wei, Liang, Wei-Ching, Gutierrez, Johnny, Young, Andrew Ah, Figueroa, Isabel, Eshghi, Shadi Toghi, Lee, ChingWei V., Kanodia, Jitendra, Snipas, Scott J., Salvesen, Guy S., Lai, Phillip, Honigberg, Lee, van Lookeren Campagne, Menno, Kirchhofer, Daniel, Baruch, Amos, Lill, Jennie R.

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Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration von Gerhardy, Stefan, Ultsch, Mark, Tang, Wanjian, Green, Evan, Holden, Jeffrey K., Li, Wei, Estevez, Alberto, Arthur, Chris, Tom, Irene, Rohou, Alexis, Kirchhofer, Daniel

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Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer von Wang, Jian-Guo, Geddings, Julia E., Aleman, Maria M., Cardenas, Jessica C., Chantrathammachart, Pichika, Williams, Julie C., Kirchhofer, Daniel, Bogdanov, Vladimir Y., Bach, Ronald R., Rak, Janusz, Church, Frank C., Wolberg, Alisa S., Pawlinski, Rafal, Key, Nigel S., Yeh, Jen Jen, Mackman, Nigel

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Excess of heme induces tissue factor-dependent activation of coagulation in mice von Sparkenbaugh, Erica M, Chantrathammachart, Pichika, Wang, Shaobin, Jonas, Will, Kirchhofer, Daniel, Gailani, David, Gruber, Andras, Kasthuri, Raj, Key, Nigel S, Mackman, Nigel, Pawlinski, Rafal

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Extracellular Histones Trigger Disseminated Intravascular Coagulation by Lytic Cell Death von Zhang, Yan, Wu, Congqing, Li, Lan, Pandeya, Ankit, Zhang, Guoying, Cui, Jian, Kirchhofer, Daniel, Wood, Jeremy P., Smyth, Susan S., Wei, Yinan, Li, Zhenyu

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Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4 von Kasperkiewicz, Paulina, Poreba, Marcin, Snipas, Scott J, Lin, S Jack, Kirchhofer, Daniel, Salvesen, Guy S, Drag, Marcin

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Proprotein convertase 7 (PCSK7) reduces apoA‐V levels von Ashraf, Yahya, Duval, Stéphanie, Sachan, Vatsal, Essalmani, Rachid, Susan‐Resiga, Delia, Roubtsova, Anna, Hamelin, Josée, Gerhardy, Stefan, Kirchhofer, Daniel, Tagliabracci, Vincent S., Prat, Annik, Kiss, Robert Scott, Seidah, Nabil G.

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Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin von Owens, 3rd, A Phillip, Passam, Freda H, Antoniak, Silvio, Marshall, Stephanie M, McDaniel, Allison L, Rudel, Lawrence, Williams, Julie C, Hubbard, Brian K, Dutton, Julie-Ann, Wang, Jianguo, Tobias, Peter S, Curtiss, Linda K, Daugherty, Alan, Kirchhofer, Daniel, Luyendyk, James P, Moriarty, Patrick M, Nagarajan, Shanmugam, Furie, Barbara C, Furie, Bruce, Johns, Douglas G, Temel, Ryan E, Mackman, Nigel

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Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease von Chantrathammachart, Pichika, Mackman, Nigel, Sparkenbaugh, Erica, Wang, Jian-Guo, Parise, Leslie V., Kirchhofer, Daniel, Key, Nigel S., Pawlinski, Rafal

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PAR-1 contributes to the innate immune response during viral infection von Antoniak, Silvio, Owens, 3rd, A Phillip, Baunacke, Martin, Williams, Julie C, Lee, Rebecca D, Weithäuser, Alice, Sheridan, Patricia A, Malz, Ronny, Luyendyk, James P, Esserman, Denise A, Trejo, JoAnn, Kirchhofer, Daniel, Blaxall, Burns C, Pawlinski, Rafal, Beck, Melinda A, Rauch, Ursula, Mackman, Nigel

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Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge von Maun, Henry R., Vij, Rajesh, Walters, Benjamin T., Morando, Ashley, Jackman, Janet K., Wu, Ping, Estevez, Alberto, Chen, Xiaocheng, Franke, Yvonne, Lipari, Michael T., Dennis, Mark S., Kirchhofer, Daniel, Ciferri, Claudio, Loyet, Kelly M., Yi, Tangsheng, Eigenbrot, Charles, Lazarus, Robert A., Koerber, James T.

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Matriptase activation connects tissue factor–dependent coagulation initiation to epithelial proteolysis and signaling von Le Gall, Sylvain M., Szabo, Roman, Lee, Melody, Kirchhofer, Daniel, Craik, Charles S., Bugge, Thomas H., Camerer, Eric

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