The effect of Bruton's tyrosine kinase (BTK) inhibitors on collagen‐induced platelet aggregation, BTK, and tyrosine kinase expressed in hepatocellular carcinoma (TEC) von Chen, Jun, Kinoshita, Taisei, Gururaja, Tarikere, Sukbuntherng, Juthamas, James, Danelle, Lu, Daniel, Whang, Jennifer, Versele, Matthias, Chang, Betty Y.

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Oncostatin M and hepatocyte growth factor induce hepatic maturation via distinct signaling pathways von Kamiya, Akihide, Kinoshita, Taisei, Miyajima, Atsushi

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Downregulation of Bim, a Proapoptotic Relative of Bcl-2, Is a Pivotal Step in Cytokine-Initiated Survival Signaling in Murine Hematopoietic Progenitors von Shinjyo, Tetsuharu, Kuribara, Ryoko, Inukai, Takeshi, Hosoi, Hajime, Kinoshita, Taisei, Miyajima, Atsushi, Houghton, Peter J., Look, A. Thomas, Ozawa, Keiya, Inaba, Toshiya

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Noninvasive imaging of in vivo MuRF1 expression during muscle atrophy von Li, Wei, Claypool, Mark D, Friera, Annabelle M, McLaughlin, John, Baltgalvis, Kristen A, Smith, Ira J, Kinoshita, Taisei, White, Kathy, Lang, Wayne, Godinez, Guillermo, Payan, Donald G, Kinsella, Todd M

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Ibrutinib Inhibits ERBB Receptor Tyrosine Kinases and HER2-Amplified Breast Cancer Cell Growth von Chen, Jun, Kinoshita, Taisei, Sukbuntherng, Juthamas, Chang, Betty Y, Elias, Laurence

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Role of Oncostatin M in hematopoiesis and liver development von Miyajima, Atsushi, Kinoshita, Taisei, Tanaka, Minoru, Kamiya, Akihide, Mukouyama, Yousuke, Hara, Takahiko

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STAT3 Down-regulates the Expression of Cyclin D during Liver Development von Matsui, Takaaki, Kinoshita, Taisei, Hirano, Toshio, Yokota, Takashi, Miyajima, Atsushi

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Hepatic Differentiation Induced by Oncostatin M Attenuates Fetal Liver Hematopoiesis von Kinoshita, Taisei, Sekiguchi, Takashi, Xu, Ming-jiang, Ito, Yoshiaki, Kamiya, Akihide, Tsuji, Koh-ichiro, Nakahata, Tatsutoshi, Miyajima, Atsushi

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851-P: Oral Long-Acting Menin Inhibitor Normalizes Type 2 Diabetes Mellitus (T2DM) in Two Rat Models von BUTLER, THOMAS, LI, WEIQUN, LAW, BRIAN, ARCHER, TENLEY, KINOSHITA, TAISEI, SOMANATH, PRIYANKA

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Relative Selectivity of Covalent Inhibitors Requires Assessment of Inactivation Kinetics and Cellular Occupancy: A Case Study of Ibrutinib and Acalabrutinib von Hopper, Melissa, Gururaja, Tarikere, Kinoshita, Taisei, Dean, James P., Hill, Ronald J., Mongan, Ann

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Raf/MAPK and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells von KINOSHITA, T, SHIROUZU, M, KAMIYA, A, HASHIMOTO, K, YOKOYAMA, S, MIYAJIMA, A

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Preclinical activity of irreversible Menin inhibitor, BMF-219, in chronic lymphocytic leukemia von Somanath, Priyanka, Lu, Daniel, Law, Brian, Archer, Tenley, Rughwani, Tripta, Kumar, Lekha, Kinoshita, Taisei, Balakrishnan, Mini, Butler, Thomas

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Novel Irreversible Menin Inhibitor, BMF-219, Shows Potent Single Agent Activity in Clinically Relevant DLBCL Cells von Somanath, Priyanka, Lu, Daniel, Law, Brian, Archer, Tenley C., Cacovean, Alexandru, Palmer, James T., Kinoshita, Taisei, Butler, Thomas

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Cultivation of aorta-gonad-mesonephros–derived hematopoietic stem cells in the fetal liver microenvironment amplifies long-term repopulating activity and enhances engraftment to th... von Takeuchi, Masaki, Sekiguchi, Takashi, Hara, Takahiko, Kinoshita, Taisei, Miyajima, Atsushi

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R-253 Disrupts Microtubule Networks in Multiple Tumor Cell Lines von GURURAJA, Tarikere L, GOFF, Dane, HITOSHI, Yasumichi, COOPER, R. D. G, PAYAN, Donald G, KINOSHITA, Taisei, GOLDSTEIN, Eileen, YUNG, Stephanie, MCLAUGHLIN, John, PALI, Erlina, JIANING HUANG, SINGH, Rajinder, DANIEL-ISSAKANI, Sarkiz

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P-107: Anti-tumor activity of covalent menin inhibitor, BMF-219, in high-grade B-cell lymphoma and multiple myeloma preclinical models von Lu, Daniel, Somanath, Priyanka, Law, Brian, Kumar, Lekha, Palmer, James, Kinoshita, Taisei, Balakrishnan, Mini, Butler, Thomas

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Kinetic Catalytic Inhibition and Cell-Based Analysis, Not Just Target Binding, Are Required to Assess Kinase Selectivity of Covalent Inhibitors: Comparable BTK vs TEC Selectivity P... von Hopper, Melissa, Gururaja, Tarikere, Kinoshita, Taisei, Dean, James P., Hill, Ronald, Mongan, Ann

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113-LB: Oral Menin Inhibitor, BMF-219, Displays a Significant and Durable Reduction in HbA1c in a Type 2 Diabetes Mellitus Rat Model von SOMANATH, PRIYANKA, MOURYA, SANCHITA, LI, WEIQUN, ARCHER, TENLEY C., LAW, BRIAN, LU, DANIEL, RUGHWANI, TRIPTA, KUMAR, LEKHA, KINOSHITA, TAISEI, BALAKRISHNAN, MINI, BUTLER, THOMAS

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Requirement of the Caspase-3/CPP32 Protease Cascade for Apoptotic Death following Cytokine Deprivation in Hematopoietic Cells von Ohta, Takayuki, Kinoshita, Taisei, Naito, Mikihiko, Nozaki, Tadashige, Masutani, Mitsuko, Tsuruo, Takashi, Miyajima, Atsushi

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Abstract 167: Ibrutinib regulates tumor microenvironment and enhances response to everolimus in renal cell carcinoma mouse models von Chen, Jun, Chen, Chun-Te, Liu, Jing, Hsu, Jeff, Kinoshita, Taisei, Chang, Betty Y.

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