Perspectives on the Designation of Oligonucleotide Starting Materials von Kiesman, William F, McPherson, Andrew K, Diorazio, Louis J, Van den Bergh, Leo, Smith, Peter D, Northall, John M, Fettes, Alec, Wang, Tiejun, Mehlmann, Martin, Raza, Syed, Held, Gary

Volltext

Development of Kilogram-Scale Convergent Liquid-Phase Synthesis of Oligonucleotides von Zhou, Xuan, Kiesman, William F, Yan, Wuming, Jiang, Hong, Antia, Firoz D, Yang, Jing, Fillon, Yannick A, Xiao, Li, Shi, Xianglin

Volltext

The Chelate Effect Rationalizes Observed Rate Acceleration and Enantioselectivity in BINOL‐Catalyzed Petasis Reactions von Haeffner, Fredrik, Pickel, Thomas C., Hou, April, Walker, Donald G., Kiesman, William F., Shi, Xianglin

Volltext

Solid-Phase Synthesis of Phosphorothioate Oligonucleotides Using Sulfurization Byproducts for in Situ Capping von Yang, Jimin, Stolee, Jessica A, Jiang, Hong, Xiao, Li, Kiesman, William F, Antia, Firoz D, Fillon, Yannick A, Ng, Austen, Shi, Xianglin

Volltext

Catalytic Asymmetric Petasis Reactions of Vinylboronates von Shi, Xianglin, Kiesman, William F, Levina, Anna, Xin, Zhili

Volltext

Synthesis of Vixotrigine, a Voltage- and Use-Dependent Sodium Channel Blocker. Part 2: Development of a Late-Stage Process von Chen, Robbie, Couming, Vincent, Guzowski, John, Irdam, Erwin, Kiesman, William F, Kwok, Daw-Iong Albert, Liang, Wenli, Mack, Tamera, O’Brien, Erin M, Opalka, Suzanne M, Patience, Daniel, Sahli, Stefan, Walker, Donald G, Osei-Yeboah, Frederick, Gu, Chaozhan, Zhang, Xin, Stöckli, Markus, Stucki, Thiemo, Matzinger, Hanspeter, Kuhn, Roman, Thut, Michael, Grohmann, Markus, Haefner, Benjamin, Lotz, Joerg, Nonnenmacher, Michael, Cerea, Paolangelo

Volltext

Acceleration of Petasis Reactions of Salicylaldehyde Derivatives with Molecular Sieves von Shi, Xianglin, Hebrault, Dominique, Humora, Michael, Kiesman, William F, Peng, Hairuo, Talreja, Tina, Wang, Zezhou, Xin, Zhili

Volltext

Process Development of an N‑Benzylated Chloropurine at the Kilogram Scale von Shi, Xianglin, Chang, Hexi, Grohmann, Markus, Kiesman, William F, Kwok, Daw-Iong Albert

Volltext

Case Studies in the Applicability of Drug Substance Design Spaces Developed on the Laboratory Scale to Commercial Manufacturing von Thomson, Nicholas M, Seibert, Kevin D, Tummala, Srinivas, Bordawekar, Shailendra, Kiesman, William F, Irdam, Erwin A, Phenix, Brian, Kumke, Daniel

Volltext

Case Studies in the Development of Drug Substance Control Strategies von Thomson, Nicholas M, Singer, Robert, Seibert, Kevin D, Luciani, Carla V, Srivastava, Sushil, Kiesman, William F, Irdam, Erwin A, Lepore, John V, Schenck, Luke

Volltext

Part 1: A Review and Perspective of the Regulatory Guidance to Support Designation and Justification of API Starting Material von Faul, Margaret M, Kiesman, William F, Smulkowski, Maciej, Pfeiffer, Steven, Busacca, Carl A, Eriksson, Magnus C, Hicks, Fred, Orr, John D

Volltext

Part 2: Designation and Justification of API Starting Materials: Current Practices across Member Companies of the IQ Consortium von Faul, Margaret M, Busacca, Carl A, Eriksson, Magnus C, Hicks, Fred, Kiesman, William F, Smulkowski, Maciej, Orr, John D, Pfeiffer, Steven

Volltext

Part 3: Designation and Justification of API Starting Materials: Proposed Framework for Alignment from an Industry Perspective von Faul, Margaret M, Argentine, Mark D, Egan, Marjorie, Eriksson, Magnus C, Ge, Zhihong, Hicks, Fred, Kiesman, William F, Mergelsberg, Ingrid, Orr, John D, Smulkowski, Maciej, Wächter, Gerald A

Volltext

Tricyclic Imidazoline Derivatives as Potent and Selective Adenosine A1 Receptor Antagonists von Vu, Chi B, Kiesman, William F, Conlon, Patrick R, Lin, Ko-Chung, Tam, Melissa, Petter, Russell C, Smits, Glenn, Lutterodt, Frank, Jin, Xiaowei, Chen, Liqing, Zhang, Jianbo

Volltext

Understanding and Control of Dimethyl Sulfate in a Manufacturing Process: Kinetic Modeling of a Fischer Esterification Catalyzed by H2SO4 von Guzowski, John P, Delaney, Edward J, Humora, Michael J, Irdam, Erwin, Kiesman, William F, Kwok, Albert, Moran, Amy D

Volltext

Potent and Orally Bioavailable 8-Bicyclo[2.2.2]octylxanthines as Adenosine A1 Receptor Antagonists von Kiesman, William F, Zhao, Jin, Conlon, Patrick R, Dowling, James E, Petter, Russell C, Lutterodt, Frank, Jin, Xiaowei, Smits, Glenn, Fure, Mary, Jayaraj, Andrew, Kim, John, Sullivan, Gail, Linden, Joel

Volltext

Detection of Aryl Radicals in Hydrodediazoniations von Wassmundt, Frederick W, Kiesman, William F

Volltext

Soluble Catalysts for Improved Pschorr Cyclizations von Wassmundt, Frederick W, Kiesman, William F

Volltext

Highly Regio- and Enantioselective Catalytic Hydrogenation of Enamides in Conjugated Diene Systems:  Synthesis and Application of γ,δ-Unsaturated Amino Acids von Burk, Mark J, Allen, John G, Kiesman, William F

Volltext

Synthesis of alkyne derivatives of a novel triazolopyrazine as A2A adenosine receptor antagonists von YAO, Gang, HAQUE, Serajul, PETTER, Russell C, LI SHA, KUMARAVEL, Gnanasambandam, WANG, Joy, ENGBER, Thomas M, WHALLEY, Eric T, CONLON, Patrick R, HEXI CHANG, KIESMAN, William F

Volltext