Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in murine heart allograft rejection von Khattar, Mithun, Baum, Caitlin E, Schroder, Paul, Breidenbach, Joshua D, Haller, Steven T, Chen, Wenhao, Stepkowski, Stanislaw

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Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions von Khattar, Mithun, Miyahara, Yoshihiro, Schroder, Paul M, Xie, Aini, Chen, Wenhao, Stepkowski, Stanislaw M

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Abstract LB-294: Synergy of an anti-HER2 ADC TAK-522 (XMT-1522) in combination with anti-PD1 monoclonal antibody (mAb) in a syngeneic breast cancer model expressing human HER2 von Traore, Tary, Khattar, Mithun

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Transient combination therapy targeting the immune synapse abrogates T cell responses and prolongs allograft survival in mice von Schroder, Paul M, Khattar, Mithun, Deng, Ronghai, Xie, Aini, Chen, Wenhao, Stepkowski, Stanislaw M

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166 Genetically engineered tumor-infiltrating lymphocytes (cytoTIL15) exhibit IL-2-independent persistence and anti-tumor efficacy against melanoma in vivo von Burga, Rachel, Khattar, Mithun, Lajoie, Scott, Pedro, Kyle, Foley, Colleen, Ocando, Alonso Villasmil, Tremblay, Jack, Primack, Benjamin, Langley, Meghan, Thornton, Dan, Tam, Stanley, Brideau, Emily, Ross, Theresa, Wilmes, Gwen, Saha, Sunandan, Helmlinger, Gabriel, Tchaicha, Jeremy, Sethi, Dhruv, Ols, Michelle, Vanasse, Gary, Subramanian, Shyam, Meulen, Jan ter

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"Default" generation of neonatal regulatory T cells von Wang, Guohua, Miyahara, Yoshihiro, Guo, Zhiyong, Khattar, Mithun, Stepkowski, Stanislaw M, Chen, Wenhao

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Abstract 3252: TAK-981: A first in class SUMO inhibitor in Phase 1 trials that promotes dendritic cell activation, antigen-presentation, and T cell priming von Khattar, Mithun, Song, Keli, Grossman, Stephen, Xega, Kristina, He, Xingyue, Idamakanti, Neeraja, Huszar, Dennis

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Interleukin 21 von Khattar, Mithun, Baum, Caitlin E, Schroder, Paul, Breidenbach, Joshua D, Haller, Steven T, Chen, Wenhao, Stepkowski, Stanislaw

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Interleukin 21 in murine heart allograft rejection von Khattar, Mithun, Baum, Caitlin E, Schroder, Paul, Breidenbach, Joshua D, Haller, Steven T, Chen, Wenhao, Stepkowski, Stanislaw

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Synergy of an anti-HER2 ADC TAK-522 (XMT-1522) in combination with anti-PD1 monoclonal antibody (mAb) in a syngeneic breast cancer model expressing human HER2 von Khattar, Mithun, Traore, Tary, Horton, Kristin, Gallery, Melissa, Brauer, Pamela, Riceberg, Jessica, Bodyak, Natalya, Protopopova, Marina, Zhang, Qingxiu, Lowinger, Timothy B., Veiby, Petter, Huszar, Dennis, Wang, Frank

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TCR stimulation without co-stimulatory signals induces expression of “tolerogenic” genes in memory CD4 T cells but does not compromise cell proliferation von Xie, Aini, Zheng, Xiong, Khattar, Mithun, Schroder, Paul, Stepkowski, Stanislaw, Xia, Jiahong, Chen, Wenhao

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Anti-TCR mAb Induces Peripheral Tolerance to Alloantigens and Delays Islet Allograft Rejection in Autoimmune Diabetic NOD Mice von Deng, Ronghai, Khattar, Mithun, Xie, Aini, Schroder, Paul M, He, Xiaoshun, Chen, Wenhao, Stepkowski, Stanislaw M

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A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells von Guo, Zhiyong, Khattar, Mithun, Schroder, Paul M, Miyahara, Yoshihiro, Wang, Guohua, He, Xiaoshung, Chen, Wenhao, Stepkowski, Stanislaw M

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IL21 is a critical regulator of chronic/persistent but not acute/accelerated auto-immune and allo-immune responses von Mithun, Khattar, Wenhao, Chen, Stanislaw, Stepkowski

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IL21 is a critical regulator of chronic/persistent auto-immune and allo-immune responses (P5162) von Khattar, Mithun, Schroder, Paul, Baum, Caitlin, Deng, Ronghai, Chen, Wenhao, Stepkowski, Stanislaw

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Novel sphingosine-1-phosphate receptor modulator KRP203 combined with locally delivered regulatory T cells induces permanent acceptance of pancreatic islet allografts von Khattar, Mithun, Deng, Ronghai, Kahan, Barry D, Schroder, Paul M, Phan, Tammy, Rutzky, Lynne P, Stepkowski, Stanislaw M

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Abstract LB212: Allogeneic, IL-2-independent tumor-infiltrating lymphocytes expressing membrane-bound IL-15 (cytoTIL15࣪) eradicate tumors in a melanoma PDX model through recognitio... von Tchaicha, Jeremy H., Lajoie, Scott, Burga, Rachel, Ross, Theresa, Primack, Benjamin, Langley, Meghan, Young, Violet, Ocando, Alonso Villasmil, Pedro, Kyle, Tremblay, Jack, Kulkarni, Gauri, Khattar, Mithun, Sethi, Dhruv, Ols, Michelle, Helmlinger, Gabriel, Vanasse, Gary, Subramanian, Shyam, ter Meulen, Jan

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PD-1-dependent restoration of self-tolerance in the NOD mouse model of diabetes after transient anti-TCR[beta] mAb therapy von Schroder, Paul M, Khattar, Mithun, Baum, Caitlin E, Miyahara, Yoshihiro, Chen, Wenhao, Vyas, Rohit, Muralidharan, Shravan, Mierzejewska, Beata, Stepkowski, Stanislaw M

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Abstract 3654: AGEN1884, an IgG1 anti-CTLA-4 antibody, combines effectively with PD-1 blockade in primary human T cell assays and in a non-human primate pharmacodynamic (PD) model von Drouin, Elise E., Savitsky, David, Gonzalez, Ana M., Gombos, Randi, Chand, Dhan, Waight, Jeremy, Yang, Xia, Khattar, Mithun, Morin, Benjamin, Findeis, Mark, Schaer, David, Merghoub, Taha, Ritter, Gerd, Tanne, Antoine, Dijk, Marc van, Goldberg, John M., Levey, Daniel, Castle, John, Cuillerot, Jean-Marie, Buell, Jennifer S., Stein, Robert, Wilson, Nicholas S.

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Abstract 4609: Agenus’ next generation cancer vaccine platforms von Uduman, Mohamed, Khattar, Mithun, Joshi, Bishnu, Tanne, Antoine, Morin, Benjamin, Karapetyan, Armen, Drouin, Elise, Craig, Sandra, Myers, Paisley, Jeffery, Erin, Wilson, Nicholas, Yang, Amy, Engelhard, Victor H., Cobbold, Mark, Hunt, Donald F., Underwood, Dennis, Lin, Shiwen, Findeis, Mark, Raizer, Jeffrey, Goldberg, John, Buell, Jennifer S., Stein, Robert, Levey, Daniel L., Castle, John

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