Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia von Tron, Adriana E., Belmonte, Matthew A., Adam, Ammar, Aquila, Brian M., Boise, Lawrence H., Chiarparin, Elisabetta, Cidado, Justin, Embrey, Kevin J., Gangl, Eric, Gibbons, Francis D., Gregory, Gareth P., Hargreaves, David, Hendricks, J. Adam, Johannes, Jeffrey W., Johnstone, Ricky W., Kazmirski, Steven L., Kettle, Jason G., Lamb, Michelle L., Matulis, Shannon M., Nooka, Ajay K., Packer, Martin J., Peng, Bo, Rawlins, Philip B., Robbins, Daniel W., Schuller, Alwin G., Su, Nancy, Yang, Wenzhan, Ye, Qing, Zheng, Xiaolan, Secrist, J. Paul, Clark, Edwin A., Wilson, David M., Fawell, Stephen E., Hird, Alexander W.

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Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival von Kettle, Jason G, Alwan, Husam, Bista, Michal, Breed, Jason, Davies, Nichola L, Eckersley, Kay, Fillery, Shaun, Foote, Kevin M, Goodwin, Louise, Jones, David R, Käck, Helena, Lau, Alan, Nissink, J. Willem M, Read, Jon, Scott, James S, Taylor, Ben, Walker, Graeme, Wissler, Lisa, Wylot, Marta

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General synthetic strategies towards N-alkyl sulfoximine building blocks for medicinal chemistry and the use of dimethylsulfoximine as a versatile precursor von Goldberg, Frederick W., Kettle, Jason G., Xiong, Jian, Lin, Daoguang

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Expanding medicinal chemistry space von Barker, Andy, Kettle, Jason G., Nowak, Thorsten, Pease, J. Elizabeth

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Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology von Goldberg, Frederick W., Kettle, Jason G., Lamont, Gillian M., Buttar, David, Ting, Attilla K. T., McGuire, Thomas M., Cook, Calum R., Beattie, David, Morentin Gutierrez, Pablo, Kavanagh, Stefan L., Komen, Jasper C., Kawatkar, Aarti, Clark, Roger, Hopcroft, Lorna, Hughes, Gareth, Critchlow, Susan E.

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Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors von McAulay, Kirsten, Hoyt, Emily A., Thomas, Morgan, Schimpl, Marianne, Bodnarchuk, Michael S., Lewis, Hilary J., Barratt, Derek, Bhavsar, Deepa, Robinson, David M., Deery, Michael J., Ogg, Derek J., Bernardes, Goncalo J. L., Ward, Richard A., Waring, Michael J., Kettle, Jason G.

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Site-Specific Quadruple-Functionalised Antibodies von Journeaux, Toby, Geeson, Michael B, Murray, Thomas V, Papworth, Monika A, Gothard, Matt, Kettle, Jason G, Vasco, Aldrin V, Bernardes, Gonçalo J L

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Standing on the shoulders of giants: a retrospective analysis of kinase drug discovery at AstraZeneca von Kettle, Jason G., Wilson, David M.

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Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization von Nilsson, Magnus, Berggren, Kristina, Berglund, Susanne, Cerboni, Silvia, Collins, Mia, Dahl, Göran, Elmqvist, David, Grimster, Neil P., Hendrickx, Ramon, Johansson, Johan R., Kettle, Jason G., Lepistö, Matti, Rhedin, Magdalena, Smailagic, Amir, Su, Qibin, Wennberg, Tiiu, Wu, Allan, Österlund, Torben, Naessens, Thomas, Mitra, Suman

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Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation von Winter, Jon J. G, Anderson, Malcolm, Blades, Kevin, Brassington, Claire, Breeze, Alexander L, Chresta, Christine, Embrey, Kevin, Fairley, Gary, Faulder, Paul, Finlay, M. Raymond V, Kettle, Jason G, Nowak, Thorsten, Overman, Ross, Patel, S. Joe, Perkins, Paula, Spadola, Loredana, Tart, Jonathan, Tucker, Julie A, Wrigley, Gail

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Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR von Pemberton, Nils, Compagne, Nina, Argyrou, Argyrides, Evertsson, Emma, Gunnarsson, Anders, Kettle, Jason G., Orme, Jonathan P., Ward, Richard A.

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Effect of Tether Length on endo/exo Stereoselectivity in Alkene–Arene meta‐Photocycloaddition Reactions towards the Aphidocolin/Stemodin Scaffolds von Alshammari, Aljazy A. A., Boyd, Joseph W., Greaves, Nicola, Kettle, Jason G., McKendrick, John E., Parker, Lewis G., Russell, Andrew T., Sani, Abubakar, Smith, Christopher D.

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Discovery of (2R)‑N‑[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]‑1H‑indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kin... von Su, Qibin, Banks, Erica, Bebernitz, Geraldine, Bell, Kirsten, Borenstein, Cassandra F, Chen, Huawei, Chuaqui, Claudio E, Deng, Nanhua, Ferguson, Andrew D, Kawatkar, Sameer, Grimster, Neil P, Ruston, Linette, Lyne, Paul D, Read, Jon A, Peng, Xianyou, Pei, Xiaohui, Fawell, Stephen, Tang, Zhanlei, Throner, Scott, Vasbinder, Melissa M, Wang, Haoyu, Winter-Holt, Jon, Woessner, Richard, Wu, Allan, Yang, Wenzhan, Zinda, Michael, Kettle, Jason G

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Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3 von Boyd, Scott, Brookfield, Joanna L, Critchlow, Susan E, Cumming, Iain A, Curtis, Nicola J, Debreczeni, Judit, Degorce, Sébastien L, Donald, Craig, Evans, Nicola J, Groombridge, Sam, Hopcroft, Philip, Jones, Neil P, Kettle, Jason G, Lamont, Scott, Lewis, Hilary J, MacFaull, Philip, McLoughlin, Sheila B, Rigoreau, Laurent J. M, Smith, James M, St-Gallay, Steve, Stock, Julie K, Turnbull, Andrew P, Wheatley, Edward R, Winter, Jon, Wingfield, Jonathan

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Discovery of N‑(4-{[5-Fluoro-7-(2-methoxyethoxy)­quinazolin-4-yl]amino}­phenyl)-2-[4-(propan-2-yl)‑1H‑1,2,3-triazol-1-yl]­acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for... von Kettle, Jason G, Anjum, Rana, Barry, Evan, Bhavsar, Deepa, Brown, Crystal, Boyd, Scott, Campbell, Andrew, Goldberg, Kristin, Grondine, Michael, Guichard, Sylvie, Hardy, Christopher J, Hunt, Tom, Jones, Rhys D. O, Li, Xiuwei, Moleva, Olga, Ogg, Derek, Overman, Ross C, Packer, Martin J, Pearson, Stuart, Schimpl, Marianne, Shao, Wenlin, Smith, Aaron, Smith, James M, Stead, Darren, Stokes, Steve, Tucker, Michael, Ye, Yang

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Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1 von Lucas, Simon C. C., Milbradt, Alexander G., Blackwell, J. Henry, Bonomo, Silvia, Brierley, Andrew, Cassar, Doyle J., Freeman, Jared, Hadfield, Thomas E., Morrill, Lucas A., Riemens, Rick, Sarda, Sunil, Schiesser, Stefan, Wiktelius, Daniel, Ahmed, Samiyah, Bostock, Mark J., Börjesson, Ulf, De Fusco, Claudia, Guerot, Carine, Hargreaves, David, Hewitt, Sarah, Lamb, Michelle L., Su, Nancy, Whatling, Ryan, Wheeler, Matthew, Kettle, Jason G.

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AZD4625 is a Potent and Selective Inhibitor of KRASG12C von Chakraborty, Atanu, Hanson, Lyndsey, Robinson, David, Lewis, Hilary, Bickerton, Sue, Davies, Michael, Polanski, Radoslaw, Whiteley, Rebecca, Koers, Alex, Atkinson, James, Baker, Tamara, Del Barco Barrantes, Ivan, Ciotta, Giovanni, Kettle, Jason G, Magiera, Lukasz, Martins, Carla P, Peter, Alison, Wigmore, Eleanor, Underwood, Zoe, Cosulich, Sabina, Niedbala, Michael, Ross, Sarah

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Identification and optimization of a novel series of selective PIP5K inhibitors von Andrews, David M., Cartic, Sharon, Cosulich, Sabina, Divecha, Nullin, Faulder, Paul, Flemington, Vikki, Kern, Oliver, Kettle, Jason G., MacDonald, Ellen, McKelvie, Jennifer, Pike, Kurt G., Roberts, Bryan, Rowlinson, Rachel, Smith, James M., Stockley, Martin, Swarbrick, Martin E., Treinies, Iris, Waring, Michael J.

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The Pharmacokinetic-Pharmacodynamic (PKPD) Relationships of AZD3229, a Novel and Selective Inhibitor of KIT, in a Range of Mouse Xenograft Models of GIST von Reddy, Venkatesh Pilla, Anjum, Rana, Grondine, Michael, Smith, Aaron, Bhavsar, Deepa, Barry, Evan, Guichard, Sylvie M., Shao, Wenlin, Kettle, Jason G., Brown, Crystal, Banks, Erica, Jones, Rhys D. O.

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Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration von Kettle, Jason G., Bagal, Sharan K., Barratt, Derek, Bodnarchuk, Michael S., Boyd, Scott, Braybrooke, Erin, Breed, Jason, Cassar, Doyle J., Cosulich, Sabina, Davies, Michael, Davies, Nichola L., Deng, Chao, Eatherton, Andrew, Evans, Laura, Feron, Lyman J., Fillery, Shaun, Gleave, Emma S., Goldberg, Frederick W., Cortés González, Miguel A., Guerot, Carine, Haider, Afreen, Harlfinger, Stephanie, Howells, Rachel, Jackson, Anne, Johnström, Peter, Kemmitt, Paul D., Koers, Alex, Kondrashov, Mikhail, Lamont, Gillian M., Lamont, Scott, Lewis, Hilary J., Liu, Libin, Mylrea, Megan, Nash, Samuel, Niedbala, Michael J., Peter, Alison, Phillips, Christopher, Pike, Kurt, Raubo, Piotr, Robb, Graeme R., Ross, Sarah, Sanders, Matthew G., Schou, Magnus, Simpson, Iain, Steward, Oliver

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