Drugging an undruggable pocket on KRAS von Kesslera, Dirk, Gmachla, Michael, Mantoulidisa, Andreas, Martin, Laetitia J., Zoephel, Andreas, Mayer, Moriz, Gollner, Andreas, Covini, David, Fischer, Silke, Gerstberger, Thomas, Gmaschitz, Teresa, Goodwin, Craig, Greb, Peter, Häring, Daniela, Hela, Wolfgang, Hoffmann, Johann, Karolyi-Oezguer, Jale, Knesl, Petr, Kornigg, Stefan, Koegl, Manfred, Kousek, Roland, Lamarre, Lyne, Moser, Franziska, Munico-Martinez, Silvia, Peinsipp, Christoph, Phan, Jason, Rinnenthal, Jörg, Sai, Jiqing, Salamon, Christian, Scherbantin, Yvonne, Schipany, Katharina, Schnitzer, Renate, Schrenk, Andreas, Sharps, Bernadette, Siszler, Gabriella, Sun, Qi, Waterson, Alex, Wolkerstorfer, Bernhard, Zeeb, Markus, Pearson, Mark, Fesik, Stephen W., McConnell, Darryl B.

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BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition von Hofmann, Marco H., Gmachl, Michael, Ramharter, Juergen, Savarese, Fabio, Gerlach, Daniel, Marszalek, Joseph R., Sanderson, Michael P., Kessler, Dirk, Trapani, Francesca, Arnhof, Heribert, Rumpel, Klaus, Botesteanu, Dana-Adriana, Ettmayer, Peter, Gerstberger, Thomas, Kofink, Christiane, Wunberg, Tobias, Zoephel, Andreas, Fu, Szu-Chin, Teh, Jessica L., Boettcher, Jark, Pototschnig, Nikolai, Schachinger, Franziska, Schipany, Katharina, Lieb, Simone, Vellano, Christopher P., O'Connell, Jonathan C., Mendes, Rachel L., Moll, Jurgen, Petronczki, Mark, Heffernan, Timothy P., Pearson, Mark, McConnell, Darryl B., Kraut, Norbert

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Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy von Beveridge, Rebecca, Kessler, Dirk, Rumpel, Klaus, Ettmayer, Peter, Meinhart, Anton, Clausen, Tim

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Direct NMR Probing of Hydration Shells of Protein Ligand Interfaces and Its Application to Drug Design von Geist, Leonhard, Mayer, Moriz, Cockcroft, Xiao-Ling, Wolkerstorfer, Bernhard, Kessler, Dirk, Engelhardt, Harald, McConnell, Darryl B, Konrat, Robert

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A ligand discovery toolbox for the WWE domain family of human E3 ligases von Münzker, Lena, Kimani, Serah W., Fowkes, Milan M., Dong, Aiping, Zheng, Hong, Li, Yanjun, Dasovich, Morgan, Zak, Krzysztof M., Leung, Anthony K. L., Elkins, Jonathan M., Kessler, Dirk, Arrowsmith, Cheryl H., Halabelian, Levon, Böttcher, Jark

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The hanging heart: How KRAS lures its prey to themembrane von Kessler, Dirk, McConnell, Darryl B.

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Stopping the beating heart of cancer: KRAS reviewed von Herdeis, Lorenz, Gerlach, Daniel, McConnell, Darryl B., Kessler, Dirk

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The hanging heart: How KRAS lures its prey to the membrane von Kessler, Dirk, McConnell, Darryl B.

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PI by NMR: Probing CH–π Interactions in Protein–Ligand Complexes by NMR Spectroscopy von Platzer, Gerald, Mayer, Moriz, Beier, Andreas, Brüschweiler, Sven, Fuchs, Julian E., Engelhardt, Harald, Geist, Leonhard, Bader, Gerd, Schörghuber, Julia, Lichtenecker, Roman, Wolkerstorfer, Bernhard, Kessler, Dirk, McConnell, Darryl B., Konrat, Robert

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One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS von Ramharter, Juergen, Kessler, Dirk, Ettmayer, Peter, Hofmann, Marco H, Gerstberger, Thomas, Gmachl, Michael, Wunberg, Tobias, Kofink, Christiane, Sanderson, Michael, Arnhof, Heribert, Bader, Gerd, Rumpel, Klaus, Zöphel, Andreas, Schnitzer, Renate, Böttcher, Jark, O’Connell, Jonathan C, Mendes, Rachel L, Richard, David, Pototschnig, Nikolai, Weiner, Irene, Hela, Wolfgang, Hauer, Katja, Haering, Daniela, Lamarre, Lyne, Wolkerstorfer, Bernhard, Salamon, Christian, Werni, Patrick, Munico-Martinez, Silvia, Meyer, Reiner, Kennedy, Matthew D, Kraut, Norbert, McConnell, Darryl B

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Drugging all RAS isoforms with one pocket von Kessler, Dirk, Bergner, Andreas, Boettcher, Jark, Fischer, Gerhard, Doebel, Sandra, Hinkel, Melanie, Muellauer, Barbara, Weiss-Puxbaum, Alexander, McConnell, Darryl B.

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KRAS Binders Hidden in Nature von Bergner, Andreas, Cockcroft, Xiaoling, Fischer, Gerhard, Gollner, Andreas, Hela, Wolfgang, Kousek, Roland, Mantoulidis, Andreas, Martin, Laetitia J., Mayer, Moriz, Müllauer, Barbara, Siszler, Gabriella, Wolkerstorfer, Bernhard, Kessler, Dirk, McConnell, Darryl B.

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Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor von Bröker, Joachim, Waterson, Alex G., Smethurst, Chris, Kessler, Dirk, Böttcher, Jark, Mayer, Moriz, Gmaschitz, Gerhard, Phan, Jason, Little, Andrew, Abbott, Jason R., Sun, Qi, Gmachl, Michael, Rudolph, Dorothea, Arnhof, Heribert, Rumpel, Klaus, Savarese, Fabio, Gerstberger, Thomas, Mischerikow, Nikolai, Treu, Matthias, Herdeis, Lorenz, Wunberg, Tobias, Gollner, Andreas, Weinstabl, Harald, Mantoulidis, Andreas, Krämer, Oliver, McConnell, Darryl B., W. Fesik, Stephen

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Neo- and Paleopolyploidy contribute to the species diversity of Asplenium the most species-rich genus of ferns von Schneider, Harald, Liu, Hong‐Mei, Chang, Yan‐Fen, Ohlsen, Daniel, Perrie, Leon R., Shepherd, Lara, Kessler, Michael, Karger, Dirk N., Hennequin, Sabine, Marquardt, Jeannine, Russell, Stephen, Ansell, Stephen, Lu, Ngan Thi, Kamau, Peris, Lóriga, Josmaily, Regalado, Ledis, Heinrichs, Jochen, Ebihara, Atsushi, Smith, Alan R., Gibby, Mary

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Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods von Kessler, Dirk, Mayer, Moriz, Zahn, Stephan K., Zeeb, Markus, Wöhrle, Simon, Bergner, Andreas, Bruchhaus, Jens, Ciftci, Tuncay, Dahmann, Georg, Dettling, Maike, Döbel, Sandra, Fuchs, Julian E., Geist, Leonhard, Hela, Wolfgang, Kofink, Christiane, Kousek, Roland, Moser, Franziska, Puchner, Teresa, Rumpel, Klaus, Scharnweber, Maximilian, Werni, Patrick, Wolkerstorfer, Bernhard, Breitsprecher, Dennis, Baaske, Philipp, Pearson, Mark, McConnell, Darryl B., Böttcher, Jark

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KRAS Binders Hidden in Nature von Bergner, Andreas, Cockcroft, Xiaoling, Fischer, Gerhard, Gollner, Andreas, Hela, Wolfgang, Kousek, Roland, Mantoulidis, Andreas, Martin, Laetitia J., Mayer, Moriz, Müllauer, Barbara, Siszler, Gabriella, Wolkerstorfer, Bernhard, Kessler, Dirk, McConnell, Darryl B.

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REPLY TO TRAN ET AL: Dimeric KRAS protein–protein interaction stabilizers von Kessler, Dirk, Gollner, Andreas, Gmachl, Michael, Mantoulidis, Andreas, Martin, Laetitia J., Zoephel, Andreas, Mayer, Moriz, Covini, David, Fischer, Silke, Gerstberger, Thomas, Gmaschitz, Teresa, Goodwin, Craig, Greb, Peter, Häring, Daniela, Hela, Wolfgang, Hoffmann, Johann, Karolyi-Oezguer, Jale, Knesl, Petr, Kornigg, Stefan, Koegl, Manfred, Kousek, Roland, Lamarre, Lyne, Moser, Franziska, Munico-Martinez, Silvia, Peinsipp, Christoph, Phan, Jason, Rinnenthal, Jörg, Sai, Jiqing, Salamon, Christian, Scherbantin, Yvonne, Schipany, Katharina, Schnitzer, Renate, Schrenk, Andreas, Sharps, Bernadette, Siszler, Gabriella, Sun, Qi, Waterson, Alex, Wolkerstorfer, Bernhard, Zeeb, Markus, Pearson, Mark, Fesik, Stephen W., McConnell, Darryl B.

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Abstract C133: Effective targeting of KRAS-driven tumors by the first-in-class, orally bioavailable SOS1::KRAS inhibitor BI-3406 von Hofmann, Marco H, Gmachl, Michael, Ramharter, Jürgen, Savarese, Fabio, Sanderson, Michael P, Gerlach, Daniel, Trapani, Francesca, Botesteanu, Dana-Adriana, Kessler, Dirk, Ettmayer, Peter, Arnhof, Heribert, Gerstberger, Thomas, Schnitzer, Renate, Kofink, Christiane, Stadtmueller, Heinz, Wunberg, Tobias, O’Connell, Jonathan C., Mendes, Rachel L, Richard, David, Saldanha, Adrian S, Moll, Juergen, Pearson, Mark, McConnell, Darryl B, Kraut, Norbert

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Front Cover: Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods (9/2021) von Kessler, Dirk, Mayer, Moriz, Zahn, Stephan K., Zeeb, Markus, Wöhrle, Simon, Bergner, Andreas, Bruchhaus, Jens, Ciftci, Tuncay, Dahmann, Georg, Dettling, Maike, Döbel, Sandra, Fuchs, Julian E., Geist, Leonhard, Hela, Wolfgang, Kofink, Christiane, Kousek, Roland, Moser, Franziska, Puchner, Teresa, Rumpel, Klaus, Scharnweber, Maximilian, Werni, Patrick, Wolkerstorfer, Bernhard, Breitsprecher, Dennis, Baaske, Philipp, Pearson, Mark, McConnell, Darryl B., Böttcher, Jark

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Abstract 3354: Chemically induced degradation of the transcription factor BCL6 von Kerres, Nina, Steurer, Steffen, Schlager, Stefanie, Bader, Gerd, Caligiuri, Maureen, Dank, Christian, Engen, John R., Ettmayer, Peter, Gerlach, Daniel, Gerstberger, Thomas, Han, Bingsong, Iacob, Roxana E., Kessler, Dirk, Lancia, David R., Moriz, Mayer, Mischerikow, Nikolai, Rumpel, Klaus, Schnitzer, Renate, Voss, Tilman, Zheng, Xiaozhang, Zoephel, Andreas, Kraut, Norbert, McConnell, Darryl, Pearson, Mark, Koegl, Manfred

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