Polysorbates 20 and 80 Used in the Formulation of Protein Biotherapeutics: Structure and Degradation Pathways von Kerwin, Bruce A.

Volltext

Protect from Light: Photodegradation and Protein Biologics von Kerwin, Bruce A., Remmele, Richard L.

Volltext

Quantitative Evaluation of Colloidal Stability of Antibody Solutions using PEG-Induced Liquid–Liquid Phase Separation von Wang, Ying, Latypov, Ramil F, Lomakin, Aleksey, Meyer, Julie A, Kerwin, Bruce A, Vunnum, Suresh, Benedek, George B

Volltext

Effect of Sugar Molecules on the Viscosity of High Concentration Monoclonal Antibody Solutions von He, Feng, Woods, Christopher E., Litowski, Jennifer R., Roschen, Lauren A., Gadgil, Himanshu S., Razinkov, Vladimir I., Kerwin, Bruce A.

Volltext

Shocking Data on Parcel Shipments of Protein Solutions von Siska, Christine, Harber, Paul, Kerwin, Bruce A.

Volltext

Characterization of Site-Specific Glycation During Process Development of a Human Therapeutic Monoclonal Antibody von Miller, Amanda K., Hambly, David M., Kerwin, Bruce A., Treuheit, Michael J., Gadgil, Himanshu S.

Volltext

Biochemical Assessment of Erythropoietin Products From Asia Versus US Epoetin alfa Manufactured by Amgen von Park, Sungae S., Park, Jihea, Ko, Jason, Chen, Louise, Meriage, David, Crouse-Zeineddini, Jill, Wong, Wendy, Kerwin, Bruce A.

Volltext

Linking the Solution Viscosity of an IgG2 Monoclonal Antibody to Its Structure as a Function of pH and Temperature von Cheng, Weiqiang, Joshi, Sangeeta B., Jain, Nishant Kumar, He, Feng, Kerwin, Bruce A., Volkin, David B., Russell Middaugh, C.

Volltext

Highly Aggregated Antibody Therapeutics Can Enhance the in Vitro Innate and Late-stage T-cell Immune Responses von Joubert, Marisa K., Hokom, Martha, Eakin, Catherine, Zhou, Lei, Deshpande, Meghana, Baker, Matthew P., Goletz, Theresa J., Kerwin, Bruce A., Chirmule, Naren, Narhi, Linda O., Jawa, Vibha

Volltext

Entanglement Model of Antibody Viscosity von Schmit, Jeremy D, He, Feng, Mishra, Shradha, Ketchem, Randal R, Woods, Christopher E, Kerwin, Bruce A

Volltext

Osmolyte Effects on Monoclonal Antibody Stability and Concentration-Dependent Protein Interactions with Water and Common Osmolytes von Barnett, Gregory V, Razinkov, Vladimir I, Kerwin, Bruce A, Blake, Steven, Qi, Wei, Curtis, Robin A, Roberts, Christopher J

Volltext

Reversible Hydrogen Transfer Reactions of Cysteine Thiyl Radicals in Peptides: the Conversion of Cysteine into Dehydroalanine and Alanine, and of Alanine into Dehydroalanine von Mozziconacci, Olivier, Kerwin, Bruce A, Schöneich, Christian

Volltext

The Photolysis of Disulfide Bonds in IgG1 and IgG2 Leads to Selective Intramolecular Hydrogen Transfer Reactions of Cysteine Thiyl Radicals, Probed by Covalent H/D Exchange and RPL... von Zhou, Shuxia, Mozziconacci, Olivier, Kerwin, Bruce A., Schöneich, Christian

Volltext

Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity von Kerwin, Bruce A., Bennett, Chelsey, Brodsky, Yan, Clark, Rutilio, Floyd, J. Alaina, Gillespie, Alison, Mayer, Bryan T., McClure, Megan, Siska, Christine, Seaman, Michael S., Seaton, Kelly E., Shaver, Jeremy, Tomaras, Georgia D., Yates, Nicole L., Ketchem, Randal R.

Volltext

Coformulation of Broadly Neutralizing Antibodies 3BNC117 and PGT121: Analytical Challenges During Preformulation Characterization and Storage Stability Studies von Patel, Ashaben, Gupta, Vineet, Hickey, John, Nightlinger, Nancy S., Rogers, Richard S., Siska, Christine, Joshi, Sangeeta B., Seaman, Michael S., Volkin, David B., Kerwin, Bruce A.

Volltext

Photolysis of an Intrachain Peptide Disulfide Bond: Primary and Secondary Processes, Formation of H2S, and Hydrogen Transfer Reactions von Mozziconacci, Olivier, Kerwin, Bruce A, Schöneich, Christian

Volltext

Effect of pH and Light on Aggregation and Conformation of an IgG1 mAb von Mason, Bruce D, Schöneich, Christian, Kerwin, Bruce A

Volltext

Evaluation of Crystal Zenith Microtiter Plates for High-Throughput Formulation Screening von Floyd, J. Alaina, Shaver, Jeremy M., Gillespie, Alison J., Park, Unjy, Rogers, Richard S., Nightlinger, Nancy S., Ogata, Yuko, James, Jeffrey J., Kerwin, Bruce A.

Volltext

Comparison of High-Throughput Biophysical Methods to Identify Stabilizing Excipients for a Model IgG2 Monoclonal Antibody: Conformational Stability and Kinetic Aggregation Measurem... von Cheng, Weiqiang, Joshi, Sangeeta B., He, Feng, Brems, David N., He, Bing, Kerwin, Bruce A., Volkin, David B., Middaugh, C. Russell

Volltext

Fluorogenic Tagging Methodology Applied to Characterize Oxidized Tyrosine and Phenylalanine in an Immunoglobulin Monoclonal Antibody von Zhou, Shuxia, Mozziconacci, Olivier, Kerwin, Bruce A., Schöneich, Christian

Volltext