A hierarchy of timescales in protein dynamics is linked to enzyme catalysis von Kern, Dorothee, Henzler-Wildman, Katherine A, Lei, Ming, Thai, Vu, Kerns, S. Jordan, Karplus, Martin

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Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation von Riglar, David T, Giessen, Tobias W, Baym, Michael, Kerns, S Jordan, Niederhuber, Matthew J, Bronson, Roderick T, Kotula, Jonathan W, Gerber, Georg K, Way, Jeffrey C, Silver, Pamela A

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Programmable bacteria detect and record an environmental signal in the mammalian gut von Kotula, Jonathan W., Kerns, S. Jordan, Shaket, Lev A., Siraj, Layla, Collins, James J., Way, Jeffrey C., Silver, Pamela A.

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Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies von Kerns, S Jordan, Belgur, Chaitra, Petropolis, Debora, Kanellias, Marianne, Barrile, Riccardo, Sam, Johannes, Weinzierl, Tina, Fauti, Tanja, Freimoser-Grundschober, Anne, Eckmann, Jan, Hage, Carina, Geiger, Martina, Ng, Patrick Ray, Tien-Street, William, Manatakis, Dimitris V, Micallef, Virginie, Gerard, Regine, Bscheider, Michael, Breous-Nystrom, Ekaterina, Schneider, Anneliese, Giusti, Anna Maria, Bertinetti-Lapatki, Cristina, Grant, Heather Shannon, Roth, Adrian B, Hamilton, Geraldine A, Singer, Thomas, Karalis, Katia, Moisan, Annie, Bruenker, Peter, Klein, Christian, Bacac, Marina, Gjorevski, Nikolce, Cabon, Lauriane

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The energy landscape of adenylate kinase during catalysis von Kerns, S Jordan, Agafonov, Roman V, Cho, Young-Jin, Pontiggia, Francesco, Otten, Renee, Pachov, Dimitar V, Kutter, Steffen, Phung, Lien A, Murphy, Padraig N, Thai, Vu, Alber, Tom, Hagan, Michael F, Kern, Dorothee

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Enhanced Utilization of Induced Pluripotent Stem Cell–Derived Human Intestinal Organoids Using Microengineered Chips von Workman, Michael J, Gleeson, John P, Troisi, Elissa J, Estrada, Hannah Q, Kerns, S. Jordan, Hinojosa, Christopher D, Hamilton, Geraldine A, Targan, Stephan R, Svendsen, Clive N, Barrett, Robert J

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Probing the transition state in enzyme catalysis by high-pressure NMR dynamics von Stiller, John B., Jordan Kerns, S., Hoemberger, Marc, Cho, Young-Jin, Otten, Renee, Hagan, Michael F., Kern, Dorothee

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Safety Profiling of Tumor-targeted T Cell-Bispecific Antibodies with Alveolus Lung- and Colon-on-Chip von Kerns, Jordan S, Belgur, Chaitra, Kanellias, Marianne, Manatakis, Dimitris V, Barrile, Riccardo, Tien-Street, Will, Ewart, Lorna, Gjorevski, Nikolche, Cabon, Lauriane

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Mutations in the Fourth EGF-like Domain Affect Thrombomodulin-Induced Changes in the Active Site of Thrombin von Koeppe, Julia R, Beach, Muneera A, Baerga-Ortiz, Abel, Kerns, S. Jordan, Komives, Elizabeth A

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A Novel Microphysiological Colon Platform to Decipher Mechanisms Driving Human Intestinal Permeability von Apostolou, Athanasia, Panchakshari, Rohit A., Banerjee, Antara, Manatakis, Dimitris V., Paraskevopoulou, Maria D., Luc, Raymond, Abu-Ali, Galeb, Dimitriou, Alexandra, Lucchesi, Carolina, Kulkarni, Gauri, Maulana, Tengku Ibrahim, Kasendra, Magdalena, Kerns, Jordan S., Bleck, Bertram, Ewart, Lorna, Manolakos, Elias S., Hamilton, Geraldine A., Giallourakis, Cosmas, Karalis, Katia

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Inflamed Intestine-Chip: Mimicking the Mucosal Microenvironment to Understand the Pathogenesis of Ulcerative Colitis von Jordan Kerns, S, Umiker, Benjamin, Obrigewitch, Jenifer, Puerta, Jefferson, Salmon, Michael, Alves, Stephen, Hamilton, Geraldine A, Karalis, Katia P

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Quorum Sensing Can Be Repurposed To Promote Information Transfer between Bacteria in the Mammalian Gut von Kim, Suhyun, Kerns, S. Jordan, Ziesack, Marika, Bry, Lynn, Gerber, Georg K, Way, Jeffrey C, Silver, Pamela A

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Altered Gut Microbiome and Inflammasome Activation in Corticotropin Releasing Hormone (CRH)- Deficient Mice Indicate a Novel Role for the Stress Hormone in the Maintenance of Intes... von Apostolou, Athanasia P, Giannogonas, Panagiotis, Manousopoulou, Antigoni, Jordan Kerns, S, Hamilton, Geraldine A, Garbis, Spiros, Karalis, Katia P

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723 - Development of a Colon-Chip to Study Host-Microbiome Interactions in Humans von Apostolou, Athanasia P., Kerns, S. Jordan, Obrigewitch, Jenifer L., Hamilton, Geraldine A., Karalis, Katia

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Abstract LB066: Assessing the safety liability of t-cell bispecific (TCB) antibodies using Ogans-on-Chips technology von Kerns, S. Jordan, Kujala, Ville, Kanellias, Marianne, Sauld, John, Tien-Street, William, Grant, Heather S., Karalis, Katia A., Hamilton, Geraldine A., Ewart, Lorna, Roth, Adrian B., Moisan, Annie, Gjorevski, Nikolche

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Tu1776 - Altered Gut Microbiome and Inflammasome Activation in Corticotropin Releasing Hormone (CRH)- Deficient Mice Indicate a Novel Role for the Stress Hormone in the Maintenance... von Apostolou, Athanasia P., Giannogonas, Panagiotis, Manousopoulou, Antigoni, Jordan Kerns, S., Hamilton, Geraldine A., Garbis, Spiros, Karalis, Katia P.

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Su1963 - Inflamed Intestine-Chip: Mimicking the Mucosal Microenvironment to Understand the Pathogenesis of Ulcerative Colitis von Jordan Kerns, S., Umiker, Benjamin, Obrigewitch, Jenifer, Puerta, Jefferson, Salmon, Michael, Alves, Stephen, Hamilton, Geraldine A., Karalis, Katia P.

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199 - Intestine-Chip: A New Model to Understand the Role of the Intestinal Epithelium in IBD by Combining Microengineering Technology and IPSC-Derived Human Intestinal Organoids von Workman, Michael, Troisi, Elissa, Kerns, S. Jordan, Hamilton, Geraldine A., Svendsen, Clive, Targan, Stephan R., Barrett, Robert J.

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Intestine-Chip: A New Model to Understand the Role of the Intestinal Epithelium in IBD by Combining Microengineering Technology and IPSC-Derived Human Intestinal Organoids von Workman, Michael, Troisi, Elissa, Kerns, S. Jordan, Hamilton, Geraldine A, Svendsen, Clive, Targan, Stephan R, Barrett, Robert J

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Engineered bacteria function in the mammalian gut as long term live diagnostics of inflammation von Riglar, David T, Giessen, Tobias W, Baym, Michael, Kerns, S Jordan, Niederhuber, Matthew J, Bronson, Roderick T, Kotula, Jonathan W, Gerber, Georg K, Way, Jeffrey C, Silver, Pamela A

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