Molecular basis of USP7 inhibition by selective small-molecule inhibitors von Turnbull, Andrew P., Ioannidis, Stephanos, Krajewski, Wojciech W., Pinto-Fernandez, Adan, Heride, Claire, Martin, Agnes C. L., Tonkin, Louise M., Townsend, Elizabeth C., Buker, Shane M., Lancia, David R., Caravella, Justin A., Toms, Angela V., Charlton, Thomas M., Lahdenranta, Johanna, Wilker, Erik, Follows, Bruce C., Evans, Nicola J., Stead, Lucy, Alli, Cristina, Zarayskiy, Vladislav V., Talbot, Adam C., Buckmelter, Alexandre J., Wang, Minghua, McKinnon, Crystal L., Saab, Fabienne, McGouran, Joanna F., Century, Hannah, Gersch, Malte, Pittman, Marc S., Marshall, C. Gary, Raynham, Tony M., Simcox, Mary, Stewart, Lorna M. D., McLoughlin, Sheila B., Escobedo, Jaime A., Bair, Kenneth W., Dinsmore, Christopher J., Hammonds, Tim R., Kim, Sunkyu, Urbé, Sylvie, Clague, Michael J., Kessler, Benedikt M., Komander, David

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Structural basis for resistance to diverse classes of NAMPT inhibitors von Wang, Weiru, Elkins, Kristi, Oh, Angela, Ho, Yen-Ching, Wu, Jiansheng, Li, Hong, Xiao, Yang, Kwong, Mandy, Coons, Mary, Brillantes, Bobby, Cheng, Eric, Crocker, Lisa, Dragovich, Peter S, Sampath, Deepak, Zheng, Xiaozhang, Bair, Kenneth W, O'Brien, Thomas, Belmont, Lisa D

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Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors von Zheng, Xiaozhang, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J, Caligiuri, Maureen, Clodfelter, Karl H, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J, Sharma, Geeta, Smith, Chase C, Wang, Zhongguo, Dragovich, Peter S, Gunzner-Toste, Janet, Liederer, Bianca M, Ly, Justin, O’Brien, Thomas, Oh, Angela, Wang, Leslie, Wang, Weiru, Xiao, Yang, Zak, Mark, Zhao, Guiling, Yuen, Po-wai, Bair, Kenneth W

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Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors von Zheng, Xiaozhang, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J, Caligiuri, Maureen, Clodfelter, Karl H, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J, Sharma, Geeta, Smith, Chase C, Wang, Zhongguo, Dragovich, Peter S, Oh, Angela, Wang, Weiru, Zak, Mark, Gunzner-Toste, Janet, Zhao, Guiling, Yuen, Po-wai, Bair, Kenneth W

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Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase von PIñA, Ivette C., GAUTSCHI, Jeffrey T., WANG, Gui-Yang-Sheng, SANDERS, Miranda L., SCHMITZ, Francis J., FRANCE, Dennis, CORNELL-KENNON, Susan, SAMBUCETTI, Lidia C., REMISZEWSKI, Stacy W., PEREZ, Larry B., BAIR, Kenneth W., CREWS, Phillip

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Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT) von Dragovich, Peter S., Bair, Kenneth W., Baumeister, Timm, Ho, Yen-Ching, Liederer, Bianca M., Liu, Xiongcai, Liu, Yongbo, O’Brien, Thomas, Oeh, Jason, Sampath, Deepak, Skelton, Nicholas, Wang, Leslie, Wang, Weiru, Wu, Hongxing, Xiao, Yang, Yuen, Po-wai, Zak, Mark, Zhang, Lei, Zheng, Xiaozhang

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Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors von Zheng, Xiaozhang, Baumeister, Timm, Buckmelter, Alexandre J, Caligiuri, Maureen, Clodfelter, Karl H, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Lin, Jian, Reynolds, Dominic J, Sharma, Geeta, Smith, Chase C, Wang, Zhongguo, Dragovich, Peter S, Oh, Angela, Wang, Weiru, Zak, Mark, Wang, Yunli, Yuen, Po-Wai, Bair, Kenneth W

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Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors von Lin, Jian, Lu, Wei, Caravella, Justin A, Campbell, Ann Marie, Diebold, R. Bruce, Ericsson, Anna, Fritzen, Edward, Gustafson, Gary R, Lancia, David R, Shelekhin, Tatiana, Wang, Zhongguo, Castro, Jennifer, Clarke, Andrea, Gotur, Deepali, Josephine, Helen R, Katz, Marie, Diep, Hien, Kershaw, Mark, Yao, Lili, Kauffman, Goss, Hubbs, Stephen E, Luke, George P, Toms, Angela V, Wang, Liann, Bair, Kenneth W, Barr, Kenneth J, Dinsmore, Christopher, Walker, Duncan, Ashwell, Susan

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Inhibitors of Human Histone Deacetylase:  Synthesis and Enzyme and Cellular Activity of Straight Chain Hydroxamates von Remiszewski, Stacy W, Sambucetti, Lidia C, Atadja, Peter, Bair, Kenneth W, Cornell, Wendy D, Green, Michael A, Howell, Kobporn Lulu, Jung, Manfred, Kwon, Paul, Trogani, Nancy, Walker, Heather

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Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway von Kung, Andrew L, Zabludoff, Sonya D, France, Dennis S, Freedman, Steven J, Tanner, Elizabeth A, Vieira, Annelisa, Cornell-Kennon, Susan, Lee, Jennifer, Wang, Beqing, Wang, Jamin, Memmert, Klaus, Naegeli, Hans-Ulrich, Petersen, Frank, Eck, Michael J, Bair, Kenneth W, Wood, Alexander W, Livingston, David M

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Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors von Zak, Mark, Yuen, Po-wai, Liu, Xiongcai, Patel, Snahel, Sampath, Deepak, Oeh, Jason, Liederer, Bianca M, Wang, Weiru, O’Brien, Thomas, Xiao, Yang, Skelton, Nicholas, Hua, Rongbao, Sodhi, Jasleen, Wang, Yunli, Zhang, Lei, Zhao, Guiling, Zheng, Xiaozhang, Ho, Yen-Ching, Bair, Kenneth W, Dragovich, Peter S

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Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN) von Martin, Matthew W., Lancia, David R., Li, Hongbin, Schiller, Shawn E.R., Toms, Angela V., Wang, Zhongguo, Bair, Kenneth W., Castro, Jennifer, Fessler, Shawn, Gotur, Deepali, Hubbs, Stephen E., Kauffman, Goss S., Kershaw, Mark, Luke, George P., McKinnon, Crystal, Yao, Lili, Lu, Wei, Millan, David S.

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Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT) von Zheng, Xiaozhang, Bair, Kenneth W., Bauer, Paul, Baumeister, Timm, Bowman, Krista K., Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Feng, Yezhen, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Li, Hong, Liang, Xiaorong, Liederer, Bianca M., Lin, Jian, Ly, Justin, O’Brien, Thomas, Oeh, Jason, Oh, Angela, Reynolds, Dominic J., Sampath, Deepak, Sharma, Geeta, Skelton, Nicholas, Smith, Chase C., Tremayne, Jarrod, Wang, Leslie, Wang, Weiru, Wang, Zhongguo, Wu, Hongxing, Wu, Jiansheng, Xiao, Yang, Yang, Guangxing, Yuen, Po-wai, Zak, Mark, Dragovich, Peter S.

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Structural and Conformational Requirements for High-Affinity Binding to the SH2 Domain of Grb2 von Ettmayer, Peter, France, Dennis, Gounarides, John, Jarosinski, Mark, Martin, Mary-Sue, Rondeau, Jean-Michel, Sabio, Michael, Topiol, Sid, Weidmann, Beat, Zurini, Mauro, Bair, Kenneth W

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Fragment-Based Identification of Amides Derived from trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) von Giannetti, Anthony M, Zheng, Xiaozhang, Skelton, Nicholas J, Wang, Weiru, Bravo, Brandon J, Bair, Kenneth W, Baumeister, Timm, Cheng, Eric, Crocker, Lisa, Feng, Yezhen, Gunzner-Toste, Janet, Ho, Yen-Ching, Hua, Rongbao, Liederer, Bianca M, Liu, Yongbo, Ma, Xiaolei, O’Brien, Thomas, Oeh, Jason, Sampath, Deepak, Shen, Youming, Wang, Chengcheng, Wang, Leslie, Wu, Hongxing, Xiao, Yang, Yuen, Po-wai, Zak, Mark, Zhao, Guiling, Zhao, Qiang, Dragovich, Peter S

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Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility von Zak, Mark, Liederer, Bianca M., Sampath, Deepak, Yuen, Po-wai, Bair, Kenneth W., Baumeister, Timm, Buckmelter, Alexandre J., Clodfelter, Karl H., Cheng, Eric, Crocker, Lisa, Fu, Bang, Han, Bingsong, Li, Guangkun, Ho, Yen-Ching, Lin, Jian, Liu, Xiongcai, Ly, Justin, O’Brien, Thomas, Reynolds, Dominic J., Skelton, Nicholas, Smith, Chase C., Tay, Suzanne, Wang, Weiru, Wang, Zhongguo, Xiao, Yang, Zhang, Lei, Zhao, Guiling, Zheng, Xiaozhang, Dragovich, Peter S.

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Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties von Gunzner-Toste, Janet, Zhao, Guiling, Bauer, Paul, Baumeister, Timm, Buckmelter, Alexandre J., Caligiuri, Maureen, Clodfelter, Karl H., Fu, Bang, Han, Bingsong, Ho, Yen-Ching, Kley, Nikolai, Liang, Xiaorong, Liederer, Bianca M., Lin, Jian, Mukadam, Sophie, O’Brien, Thomas, Oh, Angela, Reynolds, Dominic J., Sharma, Geeta, Skelton, Nicholas, Smith, Chase C., Sodhi, Jasleen, Wang, Weiru, Wang, Zhongguo, Xiao, Yang, Yuen, Po-wai, Zak, Mark, Zhang, Lei, Zheng, Xiaozhang, Bair, Kenneth W., Dragovich, Peter S.

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Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors von Towbin, Harry, Bair, Kenneth W, DeCaprio, James A, Eck, Michael J, Kim, Sunkyu, Kinder, Frederick R, Morollo, Anthony, Mueller, Dieter R, Schindler, Patrick, Song, Hyun Kyu, van Oostrum, Jan, Versace, Richard W, Voshol, Hans, Wood, Jeanette, Zabludoff, Sonya, Phillips, Penny E

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Selective Killing of Transformed Cells by Cyclin/Cyclin-Dependent Kinase 2 Antagonists von Chen, Ying-Nan P., Sharma, Sushil K., Ramsey, Timothy M., Jiang, Li, Martin, Mary S., Baker, Kayla, Adams, Peter D., Bair, Kenneth W., Kaelin, William G.

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N-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity:  Discovery of (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol... von Remiszewski, Stacy W, Sambucetti, Lidia C, Bair, Kenneth W, Bontempo, John, Cesarz, David, Chandramouli, Nagarajan, Chen, Ru, Cheung, Min, Cornell-Kennon, Susan, Dean, Karl, Diamantidis, George, France, Dennis, Green, Michael A, Howell, Kobporn Lulu, Kashi, Rina, Kwon, Paul, Lassota, Peter, Martin, Mary S, Mou, Yin, Perez, Lawrence B, Sharma, Sushil, Smith, Troy, Sorensen, Eric, Taplin, Francis, Trogani, Nancy, Versace, Richard, Walker, Heather, Weltchek-Engler, Susan, Wood, Alexander, Wu, Arthur, Atadja, Peter

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