Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment von Klitgaard, Henrik, Matagne, Alain, Nicolas, Jean‐Marie, Gillard, Michel, Lamberty, Yves, De Ryck, Marc, Kaminski, Rafal M., Leclercq, Karine, Niespodziany, Isabelle, Wolff, Christian, Wood, Martyn, Hannestad, Jonas, Kervyn, Sophie, Kenda, Benoit

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SV2A protein is a broad-spectrum anticonvulsant target: Functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy von Kaminski, Rafal M., Matagne, Alain, Leclercq, Karine, Gillard, Michel, Michel, Philippe, Kenda, Benoit, Talaga, Patrice, Klitgaard, Henrik

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Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein 2A (SV2A) Ligands with Single-Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomo... von Mercier, Joël, Archen, Laurence, Bollu, Véronique, Carré, Stéphane, Evrard, Yves, Jnoff, Eric, Kenda, Benoît, Lallemand, Bénédicte, Michel, Philippe, Montel, Florian, Moureau, Florence, Price, Nathalie, Quesnel, Yannick, Sauvage, Xavier, Valade, Anne, Provins, Laurent

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Discovery of 4-Substituted Pyrrolidone Butanamides as New Agents with Significant Antiepileptic Activity von Kenda, Benoit M, Matagne, Alain C, Talaga, Patrice E, Pasau, Patrick M, Differding, Edmond, Lallemand, Bénédicte I, Frycia, Anne M, Moureau, Florence G, Klitgaard, Henrik V, Gillard, Michel R, Fuks, Bruno, Michel, Philippe

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Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy von Matagne, Alain, Margineanu, Doru-Georg, Potschka, Heidrun, Löscher, Wolfgang, Michel, Philippe, Kenda, Benoit, Klitgaard, Henrik

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Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein2A (SV2A) Ligands with Single-Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomog... von Mercier, Joël, Archen, Laurence, Bollu, Véronique, Carre, Stéphane, Evrard, Yves, Jnoff, Eric, Kenda, Benoît, Lallemand, Bénédicte, Michel, Philippe, Montel, Florian, Moureau, Florence, Price, Nathalie, Quesnel, Yannick, Sauvage, Xavier, Valade, Anne, Provins, Laurent

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[ super(11)C]UCB-A, a novel PET tracer for synaptic vesicle protein 2 A von Estradaa, Sergio, Lubberinkb, Mark, Thibblinb, Alf, Sprychad, Margareta, Buchanane, Tim, Mestdaghe, Nathalie, Kendae, Benoit, Merciere, Joel, Provinse, Laurent, Gillarde, Michel, Tytgate, Dominique, Antonia, Gunnar

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Brivaracetam: Rationale for discovery and preclinical profile of a selective SV 2A ligand for epilepsy treatment von Klitgaard, Henrik, Matagne, Alain, Nicolas, Jean‐Marie, Gillard, Michel, Lamberty, Yves, De Ryck, Marc, Kaminski, Rafal M., Leclercq, Karine, Niespodziany, Isabelle, Wolff, Christian, Wood, Martyn, Hannestad, Jonas, Kervyn, Sophie, Kenda, Benoit

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[11C]UCB-A, a novel PET tracer for synaptic vesicle protein 2A von Estrada, Sergio, Lubberink, Mark, Thibblin, Alf, Sprycha, Margareta, Buchanan, Tim, Mestdagh, Nathalie, Kenda, Benoit, Mercier, Joel, Provins, Laurent, Gillard, Michel, Tytgat, Dominique, Antoni, Gunnar

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[11 C]UCB-A, a n3ovel PET tracer for synaptic vesicle protein 2A von Estrada, Sergio, Lubberink, Mark, Thibblin, Alf, Sprycha, Margareta, Buchanan, Tim, Mestdagh, Nathalie, Kenda, Benoit, Mercier, Joel, Provins, Laurent, Gillard, Michel, Tytgat, Dominique, Antoni, Gunnar

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Discovery of Indolone Acetamides as Novel SV2A Ligands with Improved Potency Toward Seizure Suppression von Frycia, Anne, Starck, Jean-Philippe, Jadot, Sophie, Lallemand, Bénédicte, Leclercq, Karine, Lo Brutto, Patrick, Matagne, Alain, Verbois, Valérie, Mercier, Joël, Kenda, Benoit

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Cover Picture: Discovery of Indolone Acetamides as Novel SV2A Ligands with Improved Potency Toward Seizure Suppression (ChemMedChem 2/2010) von Frycia, Anne, Starck, Jean-Philippe, Jadot, Sophie, Lallemand, Bénédicte, Leclercq, Karine, Lo Brutto, Patrick, Matagne, Alain, Verbois, Valérie, Mercier, Joël, Kenda, Benoit

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Dendrophanes: Water-soluble dendritic receptors as models for buried recognition sites in globular proteins von Mattei, Sebastiano, Wallimann, Peter, Kenda, Benoit, Amrein, Walter, Diederich, Fraçois

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CRM1 inhibitors for treating epilepsy von Lee, Margaret, Leclercq, Karine, Tamir, Sharon, Kenda, Benoit, De Ryck, Marc, Kaminski, Rafal M

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2-Oxo-1-pyrrolidine derivatives, process of their preparation and their use von DIFFERDING EDMOND, LALLEMAND BÉNÉDICTE, MICHEL PHILLIPPE, PASAU PATRICK, MATAGNE ALAIN, KENDA BENOIT KENDA, TALAGA PATRICE

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Original reactions of α,α-dithio aryl alkanes with butyllithiums von Krief, Alain, Kenda, Benoĭt, Barbeaux, Phillippe

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COMPOUNDS FOR ENHANCING THE COGNITIVE FUNCTION von JNOFF, ERIC, KENDA, BENOIT

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Stereoselective syntheses of 1,2-dialkyl-1-phenyl cyclopentanes involving intramolecular carbolithiation of olefins von Krief, Alain, Kenda, Benoît, Maertens, Christophe, Remacle, Bruno

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Synthesis of arylcycloalkanes from ω-alkenyl benzylselenides von Krief, Alain, Kenda, Benoit, Barbeaux, Phillipe, Guittet, Eric

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Methods for Enhancing the Cognitive Function von MATAGNE ALAIN, KENDA BENOIT

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