In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability von Sharma, Vikas K., Patapoff, Thomas W., Kabakoff, Bruce, Pai, Satyan, Hilario, Eric, Zhang, Boyan, Li, Charlene, Borisov, Oleg, Kelley, Robert F., Chorny, Ilya, Zhou, Joe Z., Dill, Ken A., Swartz, Trevor E.

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Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab von Ultsch, Mark, Bevers, Jack, Nakamura, Gerald, Vandlen, Richard, Kelley, Robert F., Wu, Lawren C., Eigenbrot, Charles

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K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody von Matsumoto, Marissa L., Wickliffe, Katherine E., Dong, Ken C., Yu, Christine, Bosanac, Ivan, Bustos, Daisy, Phu, Lilian, Kirkpatrick, Donald S., Hymowitz, Sarah G., Rape, Michael, Kelley, Robert F., Dixit, Vishva M.

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High affinity antigen recognition of the dual specific variants of herceptin is entropy-driven in spite of structural plasticity von Bostrom, Jenny, Haber, Lauric, Koenig, Patrick, Kelley, Robert F, Fuh, Germaine

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Effect of Individual Fc Methionine Oxidation on FcRn Binding: Met252 Oxidation Impairs FcRn Binding More Profoundly than Met428 Oxidation von Gao, Xuan, Ji, Junyan A., Veeravalli, Karthik, John Wang, Y., Zhang, Taylor, Mcgreevy, William, Zheng, Kai, Kelley, Robert F., Laird, Michael W., Liu, Jun, Cromwell, Mary

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Enhancing the antitumor efficacy of a cell-surface death ligand by covalent membrane display von Nair, Pradeep M., Flores, Heather, Gogineni, Alvin, Marsters, Scot, Lawrence, David A., Kelley, Robert F., Ngu, Hai, Sagolla, Meredith, Komuves, Laszlo, Bourgon, Richard, Settleman, Jeffrey, Ashkenazi, Avi

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Glycan Shifting on Hepatitis C Virus (HCV) E2 Glycoprotein Is a Mechanism for Escape from Broadly Neutralizing Antibodies von Pantua, Homer, Diao, Jingyu, Ultsch, Mark, Hazen, Meredith, Mathieu, Mary, McCutcheon, Krista, Takeda, Kentaro, Date, Shailesh, Cheung, Tommy K., Phung, Qui, Hass, Phil, Arnott, David, Hongo, Jo-Anne, Matthews, David J., Brown, Alex, Patel, Arvind H., Kelley, Robert F., Eigenbrot, Charles, Kapadia, Sharookh B.

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Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye von Shatz, Whitney, Hass, Philip E, Peer, Nikhil, Paluch, Maciej T, Blanchette, Craig, Han, Guanghui, Sandoval, Wendy, Morando, Ashley, Loyet, Kelly M, Bantseev, Vladimir, Booler, Helen, Crowell, Susan, Kamath, Amrita, Scheer, Justin M, Kelley, Robert F

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A strategy for risk mitigation of antibodies with fast clearance von Hötzel, Isidro, Theil, Frank-Peter, Bernstein, Lisa J., Prabhu, Saileta, Deng, Rong, Quintana, Leah, Lutman, Jeff, Sibia, Renuka, Chan, Pamela, Bumbaca, Daniela, Fielder, Paul, Carter, Paul J., Kelley, Robert F.

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Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics von Bumbaca Yadav, Daniela, Sharma, Vikas K., Boswell, Charles Andrew, Hotzel, Isidro, Tesar, Devin, Shang, Yonglei, Ying, Yong, Fischer, Saloumeh K., Grogan, Jane L., Chiang, Eugene Y., Urban, Konnie, Ulufatu, Sheila, Khawli, Leslie A., Prabhu, Saileta, Joseph, Sean, Kelley, Robert F.

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Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody von Matsumoto, Marissa L., Dong, Ken C., Yu, Christine, Phu, Lilian, Gao, Xinxin, Hannoush, Rami N., Hymowitz, Sarah G., Kirkpatrick, Donald S., Dixit, Vishva M., Kelley, Robert F.

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Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab von Shatz, Whitney, Hass, Philip E, Mathieu, Mary, Kim, Hok Seon, Leach, Kim, Zhou, Michelle, Crawford, Yongping, Shen, Amy, Wang, Kathryn, Chang, Debby P, Maia, Mauricio, Crowell, Susan R, Dickmann, Leslie, Scheer, Justin M, Kelley, Robert F

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Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge von Li, Bing, Tesar, Devin, Boswell, C Andrew, Cahaya, Hendry S, Wong, Anne, Zhang, Jianhuan, Meng, Y Gloria, Eigenbrot, Charles, Pantua, Homer, Diao, Jinyu, Kapadia, Sharookh B, Deng, Rong, Kelley, Robert F

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Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms von Hecht, Elizabeth Sara, Mehta, Shrenik, Wecksler, Aaron T, Aguilar, Ben, Swanson, Nathaniel, Phung, Wilson, Dubey Kelsoe, Ananya, Benner, W Henry, Tesar, Devin, Kelley, Robert F, Sandoval, Wendy, Sreedhara, Alavattam

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Retinal and Lens Degeneration in New Zealand White Rabbits Administered Intravitreal TSG-6 Link Domain-Rabbit FAb Fusion Proteins von Laing, Steven T., Tassew, Nardos, Tesar, Devin, Wang, Yue, Crowell, Susan R., Gray, Julia, Kwong, Mandy, Loyet, Kelly M., Andaya, Roxanne, Kusi, Aija, Kelley, Robert F.

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Improved Quantitative Mass Spectrometry Methods for Characterizing Complex Ubiquitin Signals von Phu, Lilian, Izrael-Tomasevic, Anita, Matsumoto, Marissa L., Bustos, Daisy, Dynek, Jasmin N., Fedorova, Anna V., Bakalarski, Corey E., Arnott, David, Deshayes, Kurt, Dixit, Vishva M., Kelley, Robert F., Vucic, Domagoj, Kirkpatrick, Donald S.

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Receptor-selective Mutants of Apoptosis-inducing Ligand 2/Tumor Necrosis Factor-related Apoptosis-inducing Ligand Reveal a Greater Contribution of Death Receptor (DR) 5 than DR4 to... von Kelley, Robert F., Totpal, Klara, Lindstrom, Stephanie H., Mathieu, Mary, Billeci, Karen, DeForge, Laura, Pai, Roger, Hymowitz, Sarah G., Ashkenazi, Avi

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Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics von Shivva, Vittal, Boswell, C. Andrew, Rafidi, Hanine, Kelley, Robert F., Kamath, Amrita, Crowell, Susan R.

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Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 von CUILING ZHONG, JIANYONG WANG, QUINTANA, Leah, GRIBLING, Peter, SUTO, Eric, BARCK, Kai, CORPUZ, Racquel, YAO, Jenny, TAKKAR, Rashi, LEE, Wyne P, DAMICO-BEYER, Lisa A, CARANO, Richard D, BING LI, ADAMS, Camellia, KELLEY, Robert F, WEIRU WANG, FERRARA, Napoleone, HONG XIANG, ULTSCH, Mark, COONS, Mary, WONG, Terence, CHIANG, Nancy Y, CLARK, Suzy, CLARK, Robyn

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Tyrosine Plays a Dominant Functional Role in the Paratope of a Synthetic Antibody Derived from a Four Amino Acid Code von Fellouse, Frederic A., Barthelemy, Pierre A., Kelley, Robert F., Sidhu, Sachdev S.

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