RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors von Zhao, Xuesong, Ponomaryov, Tatyana, Ornell, Kimberly J, Zhou, Pengcheng, Dabral, Sukriti K, Pak, Ekaterina, Li, Wei, Atwood, Scott X, Whitson, Ramon J, Chang, Anne Lynn S, Li, Jiang, Oro, Anthony E, Chan, Jennifer A, Kelleher, Joseph F, Segal, Rosalind A

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Discovery of NVP-LEQ506, a Second-Generation Inhibitor of Smoothened von Peukert, Stefan, He, Feng, Dai, Miao, Zhang, Rui, Sun, Yingchuan, Miller-Moslin, Karen, McEwan, Michael, Lagu, Bharat, Wang, Kate, Yusuff, Naeem, Bourret, Aaron, Ramamurthy, Arun, Maniara, Wieslawa, Amaral, Adam, Vattay, Anthony, Wang, Anlai, Guo, Ribo, Yuan, Jing, Green, John, Williams, Juliet, Buonamici, Silvia, Kelleher III, Joseph F., Dorsch, Marion

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Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities von Gruber Filbin, Mariella, Dabral, Sukriti K, Pazyra-Murphy, Maria F, Ramkissoon, Shakti, Kung, Andrew L, Pak, Ekaterina, Chung, Jarom, Theisen, Matthew A, Sun, Yanping, Franchetti, Yoko, Sun, Yu, Shulman, David S, Redjal, Navid, Tabak, Barbara, Beroukhim, Rameen, Wang, Qi, Zhao, Jean, Dorsch, Marion, Buonamici, Silvia, Ligon, Keith L, Kelleher, Joseph F, Segal, Rosalind A

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Essential role of stromally induced hedgehog signaling in B-cell malignancies von Dierks, Christine, Warmuth, Markus, Grbic, Jovana, Zirlik, Katja, Beigi, Ronak, Englund, Nathan P, Guo, Gui-Rong, Veelken, Hendrik, Engelhardt, Monika, Mertelsmann, Roland, Kelleher, Joseph F, Schultz, Peter

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Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist von Pan, Shifeng, Wu, Xu, Jiang, Jiqing, Gao, Wenqi, Wan, Yongqin, Cheng, Dai, Han, Dong, Liu, Jun, Englund, Nathan P, Wang, Yan, Peukert, Stefan, Miller-Moslin, Karen, Yuan, Jing, Guo, Ribo, Matsumoto, Melissa, Vattay, Anthony, Jiang, Yun, Tsao, Jeffrey, Sun, Fangxian, Pferdekamper, AnneMarie C, Dodd, Stephanie, Tuntland, Tove, Maniara, Wieslawa, Kelleher, Joseph F, Yao, Yung-mae, Warmuth, Markus, Williams, Juliet, Dorsch, Marion

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A Transposon Screen Identifies Loss of Primary Cilia as a Mechanism of Resistance to SMO Inhibitors von Zhao, Xuesong, Pak, Ekaterina, Ornell, Kimberly J, Pazyra-Murphy, Maria F, MacKenzie, Ethan L, Chadwick, Emily J, Ponomaryov, Tatyana, Kelleher, Joseph F, Segal, Rosalind A

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Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway von Roberts, Charles W M, Dorsch, Marion, Jagani, Zainab, Mora-Blanco, E Lorena, Sansam, Courtney G, McKenna, Elizabeth S, Wilson, Boris, Chen, Dongshu, Klekota, Justin, Tamayo, Pablo, Nguyen, Phuong T L, Tolstorukov, Michael, Park, Peter J, Cho, Yoon-Jae, Hsiao, Kathy, Buonamici, Silvia, Pomeroy, Scott L, Mesirov, Jill P, Ruffner, Heinz, Bouwmeester, Tewis, Luchansky, Sarah J, Murtie, Joshua, Kelleher, Joseph F, Warmuth, Markus, Sellers, William R

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Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39 von Bassilana, Frederic, Carlson, Adam, DaSilva, Jennifer A, Grosshans, Bianka, Vidal, Solange, Beck, Valerie, Wilmeringwetter, Barbara, Llamas, Luis A, Showalter, Todd B, Rigollier, Pascal, Bourret, Aaron, Ramamurthy, Arun, Wu, Xu, Harbinski, Fred, Plonsky, Samantha, Lee, Lac, Ruffner, Heinz, Grandi, Paola, Schirle, Markus, Jenkins, Jeremy, Sailer, Andreas W, Bouwmeester, Tewis, Porter, Jeffrey A, Myer, Vic, Finan, Peter M, Tallarico, John A, Kelleher, Joseph F, Seuwen, Klaus, Jain, Rishi K, Luchansky, Sarah J

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Topical Treatment of Basal Cell Carcinomas in Nevoid Basal Cell Carcinoma Syndrome with a Smoothened Inhibitor von Skvara, Hans, Kalthoff, Frank, Meingassner, Josef G., Wolff-Winiski, Barbara, Aschauer, Heinrich, Kelleher, Joseph F., Wu, Xu, Pan, Shifeng, Mickel, Lesanka, Schuster, Christopher, Stary, Georg, Jalili, Ahmad, David, Olivier J., Emotte, Corinne, Antunes, Ana Monica Costa, Rose, Kristine, Decker, Jeremy, Carlson, Ilene, Gardner, Humphrey, Stuetz, Anton, Bertolino, Arthur P., Stingl, Georg, De Rie, Menno A.

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Characterisation of the crack tip plastic zone in fatigue via synchrotron X‐ray diffraction von Carrera, Manuel, Cruces, Alejandro S., Kelleher, Joseph F., Tai, Yee‐Han, Yates, John R., Withers, Philip J., Lopez‐Crespo, Pablo

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1-Amino-4-benzylphthalazines as Orally Bioavailable Smoothened Antagonists with Antitumor Activity von Miller-Moslin, Karen, Peukert, Stefan, Jain, Rishi K, McEwan, Michael A, Karki, Rajesh, Llamas, Luis, Yusuff, Naeem, He, Feng, Li, Yanhong, Sun, Yingchuan, Dai, Miao, Perez, Lawrence, Michael, Walter, Sheng, Tao, Lei, Huangshu, Zhang, Rui, Williams, Juliet, Bourret, Aaron, Ramamurthy, Arun, Yuan, Jing, Guo, Ribo, Matsumoto, Melissa, Vattay, Anthony, Maniara, Wieslawa, Amaral, Adam, Dorsch, Marion, Kelleher, Joseph F

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Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures von Kelleher, Joseph, Dickinson, Adam, Cain, Stuart, Hu, Yanhua, Bates, Nicola, Harvey, Adam, Ren, Jianzhen, Zhang, Wenjun, Moreton, Fiona C., Muir, Keith W., Ward, Christopher, Touyz, Rhian M., Sharma, Pankaj, Xu, Qingbo, Kimber, Susan J., Wang, Tao

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Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39 von Bassilana, Frederic, Carlson, Adam, DaSilva, Jennifer A, Grosshans, Bianka, Vidal, Solange, Beck, Valerie, Wilmeringwetter, Barbara, Llamas, Luis A, Showalter, Todd B, Rigollier, Pascal, Bourret, Aaron, Ramamurthy, Arun, Wu, Xu, Harbinski, Fred, Plonsky, Samantha, Lee, Lac, Ruffner, Heinz, Grandi, Paola, Schirle, Markus, Jenkins, Jeremy, Sailer, Andreas W, Bouwmeester, Tewis, Porter, Jeffrey A, Myer, Vic, Finan, Peter M, Tallarico, John A, Kelleher, Joseph F, Seuwen, Klaus, Jain, Rishi K, Luchansky, Sarah J

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Identification and structure–activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway von Peukert, Stefan, Jain, Rishi K., Geisser, Adrian, Sun, Yingchuan, Zhang, Rui, Bourret, Aaron, Carlson, Adam, DaSilva, Jennifer, Ramamurthy, Arun, Kelleher, Joseph F.

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Cover Picture: Discovery of NVP-LEQ506, a Second-Generation Inhibitor of Smoothened (ChemMedChem 8/2013) von Peukert, Stefan, He, Feng, Dai, Miao, Zhang, Rui, Sun, Yingchuan, Miller-Moslin, Karen, McEwan, Michael, Lagu, Bharat, Wang, Kate, Yusuff, Naeem, Bourret, Aaron, Ramamurthy, Arun, Maniara, Wieslawa, Amaral, Adam, Vattay, Anthony, Wang, Anlai, Guo, Ribo, Yuan, Jing, Green, John, Williams, Juliet, Buonamici, Silvia, Kelleher III, Joseph F., Dorsch, Marion

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Sequences, Structural Models, and Cellular Localization of the Actin-Related Proteins Arp2 and Arp3 from Acanthamoeba von Kelleher, Joseph F., Atkinson, Simon J., Pollard, Thomas D.

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Arp2/3 complex from Acanthamoeba binds profilin and cross-links actin filaments von Mullins, R D, Kelleher, J F, Xu, J, Pollard, T D

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Abstract 5222: Degraders targeting both IRAK4 and IMiD substrates show combinatorial effects leading to broader activity with durable and complete regressions in MYD88 mutant lymph... von Walker, Duncan H., Mayo, Michele, Klaus, Christine, Rong, Haojing, Rusin, Scott, Sharma, Kirti, McDonald, Alice, Campbell, Veronica, Kelleher, Joseph, Gollob, Jared, Mainolfi, Nello, Weiss, Matt

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A method for estimating the risk of drug-induced phototoxicity and its application to smoothened inhibitors von Peukert, Stefan, Nunez, Jill, He, Feng, Dai, Miao, Yusuff, Naeem, DiPesa, Alan, Miller-Moslin, Karen, Karki, Rajesh, Lagu, Bharat, Harwell, Chris, Zhang, Yalin, Bauer, Daniel, Kelleher, Joseph F., Egan, William

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187 Induced Pluripotent Stem Cell (IPSC) Model of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) von Kelleher, Joseph, Wang, Tao, Dickinson, Adam, Kimber, Susan

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