RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors von Zhao, Xuesong, Ponomaryov, Tatyana, Ornell, Kimberly J, Zhou, Pengcheng, Dabral, Sukriti K, Pak, Ekaterina, Li, Wei, Atwood, Scott X, Whitson, Ramon J, Chang, Anne Lynn S, Li, Jiang, Oro, Anthony E, Chan, Jennifer A, Kelleher, Joseph F, Segal, Rosalind A

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Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities von Gruber Filbin, Mariella, Dabral, Sukriti K, Pazyra-Murphy, Maria F, Ramkissoon, Shakti, Kung, Andrew L, Pak, Ekaterina, Chung, Jarom, Theisen, Matthew A, Sun, Yanping, Franchetti, Yoko, Sun, Yu, Shulman, David S, Redjal, Navid, Tabak, Barbara, Beroukhim, Rameen, Wang, Qi, Zhao, Jean, Dorsch, Marion, Buonamici, Silvia, Ligon, Keith L, Kelleher, Joseph F, Segal, Rosalind A

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Essential role of stromally induced hedgehog signaling in B-cell malignancies von Dierks, Christine, Warmuth, Markus, Grbic, Jovana, Zirlik, Katja, Beigi, Ronak, Englund, Nathan P, Guo, Gui-Rong, Veelken, Hendrik, Engelhardt, Monika, Mertelsmann, Roland, Kelleher, Joseph F, Schultz, Peter

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Discovery of NVP-LEQ506, a Second-Generation Inhibitor of Smoothened von Peukert, Stefan, He, Feng, Dai, Miao, Zhang, Rui, Sun, Yingchuan, Miller-Moslin, Karen, McEwan, Michael, Lagu, Bharat, Wang, Kate, Yusuff, Naeem, Bourret, Aaron, Ramamurthy, Arun, Maniara, Wieslawa, Amaral, Adam, Vattay, Anthony, Wang, Anlai, Guo, Ribo, Yuan, Jing, Green, John, Williams, Juliet, Buonamici, Silvia, Kelleher III, Joseph F., Dorsch, Marion

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A Transposon Screen Identifies Loss of Primary Cilia as a Mechanism of Resistance to SMO Inhibitors von Zhao, Xuesong, Pak, Ekaterina, Ornell, Kimberly J, Pazyra-Murphy, Maria F, MacKenzie, Ethan L, Chadwick, Emily J, Ponomaryov, Tatyana, Kelleher, Joseph F, Segal, Rosalind A

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Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist von Pan, Shifeng, Wu, Xu, Jiang, Jiqing, Gao, Wenqi, Wan, Yongqin, Cheng, Dai, Han, Dong, Liu, Jun, Englund, Nathan P, Wang, Yan, Peukert, Stefan, Miller-Moslin, Karen, Yuan, Jing, Guo, Ribo, Matsumoto, Melissa, Vattay, Anthony, Jiang, Yun, Tsao, Jeffrey, Sun, Fangxian, Pferdekamper, AnneMarie C, Dodd, Stephanie, Tuntland, Tove, Maniara, Wieslawa, Kelleher, Joseph F, Yao, Yung-mae, Warmuth, Markus, Williams, Juliet, Dorsch, Marion

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Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway von Roberts, Charles W M, Dorsch, Marion, Jagani, Zainab, Mora-Blanco, E Lorena, Sansam, Courtney G, McKenna, Elizabeth S, Wilson, Boris, Chen, Dongshu, Klekota, Justin, Tamayo, Pablo, Nguyen, Phuong T L, Tolstorukov, Michael, Park, Peter J, Cho, Yoon-Jae, Hsiao, Kathy, Buonamici, Silvia, Pomeroy, Scott L, Mesirov, Jill P, Ruffner, Heinz, Bouwmeester, Tewis, Luchansky, Sarah J, Murtie, Joshua, Kelleher, Joseph F, Warmuth, Markus, Sellers, William R

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Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39 von Bassilana, Frederic, Carlson, Adam, DaSilva, Jennifer A, Grosshans, Bianka, Vidal, Solange, Beck, Valerie, Wilmeringwetter, Barbara, Llamas, Luis A, Showalter, Todd B, Rigollier, Pascal, Bourret, Aaron, Ramamurthy, Arun, Wu, Xu, Harbinski, Fred, Plonsky, Samantha, Lee, Lac, Ruffner, Heinz, Grandi, Paola, Schirle, Markus, Jenkins, Jeremy, Sailer, Andreas W, Bouwmeester, Tewis, Porter, Jeffrey A, Myer, Vic, Finan, Peter M, Tallarico, John A, Kelleher, Joseph F, Seuwen, Klaus, Jain, Rishi K, Luchansky, Sarah J

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1-Amino-4-benzylphthalazines as Orally Bioavailable Smoothened Antagonists with Antitumor Activity von Miller-Moslin, Karen, Peukert, Stefan, Jain, Rishi K, McEwan, Michael A, Karki, Rajesh, Llamas, Luis, Yusuff, Naeem, He, Feng, Li, Yanhong, Sun, Yingchuan, Dai, Miao, Perez, Lawrence, Michael, Walter, Sheng, Tao, Lei, Huangshu, Zhang, Rui, Williams, Juliet, Bourret, Aaron, Ramamurthy, Arun, Yuan, Jing, Guo, Ribo, Matsumoto, Melissa, Vattay, Anthony, Maniara, Wieslawa, Amaral, Adam, Dorsch, Marion, Kelleher, Joseph F

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Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39 von Bassilana, Frederic, Carlson, Adam, DaSilva, Jennifer A, Grosshans, Bianka, Vidal, Solange, Beck, Valerie, Wilmeringwetter, Barbara, Llamas, Luis A, Showalter, Todd B, Rigollier, Pascal, Bourret, Aaron, Ramamurthy, Arun, Wu, Xu, Harbinski, Fred, Plonsky, Samantha, Lee, Lac, Ruffner, Heinz, Grandi, Paola, Schirle, Markus, Jenkins, Jeremy, Sailer, Andreas W, Bouwmeester, Tewis, Porter, Jeffrey A, Myer, Vic, Finan, Peter M, Tallarico, John A, Kelleher, Joseph F, Seuwen, Klaus, Jain, Rishi K, Luchansky, Sarah J

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Topical Treatment of Basal Cell Carcinomas in Nevoid Basal Cell Carcinoma Syndrome with a Smoothened Inhibitor von Skvara, Hans, Kalthoff, Frank, Meingassner, Josef G., Wolff-Winiski, Barbara, Aschauer, Heinrich, Kelleher, Joseph F., Wu, Xu, Pan, Shifeng, Mickel, Lesanka, Schuster, Christopher, Stary, Georg, Jalili, Ahmad, David, Olivier J., Emotte, Corinne, Antunes, Ana Monica Costa, Rose, Kristine, Decker, Jeremy, Carlson, Ilene, Gardner, Humphrey, Stuetz, Anton, Bertolino, Arthur P., Stingl, Georg, De Rie, Menno A.

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Characterisation of the crack tip plastic zone in fatigue via synchrotron X‐ray diffraction von Carrera, Manuel, Cruces, Alejandro S., Kelleher, Joseph F., Tai, Yee‐Han, Yates, John R., Withers, Philip J., Lopez‐Crespo, Pablo

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Cover Picture: Discovery of NVP-LEQ506, a Second-Generation Inhibitor of Smoothened (ChemMedChem 8/2013) von Peukert, Stefan, He, Feng, Dai, Miao, Zhang, Rui, Sun, Yingchuan, Miller-Moslin, Karen, McEwan, Michael, Lagu, Bharat, Wang, Kate, Yusuff, Naeem, Bourret, Aaron, Ramamurthy, Arun, Maniara, Wieslawa, Amaral, Adam, Vattay, Anthony, Wang, Anlai, Guo, Ribo, Yuan, Jing, Green, John, Williams, Juliet, Buonamici, Silvia, Kelleher III, Joseph F., Dorsch, Marion

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Identification and structure–activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway von Peukert, Stefan, Jain, Rishi K., Geisser, Adrian, Sun, Yingchuan, Zhang, Rui, Bourret, Aaron, Carlson, Adam, DaSilva, Jennifer, Ramamurthy, Arun, Kelleher, Joseph F.

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A method for estimating the risk of drug-induced phototoxicity and its application to smoothened inhibitors von Peukert, Stefan, Nunez, Jill, He, Feng, Dai, Miao, Yusuff, Naeem, DiPesa, Alan, Miller-Moslin, Karen, Karki, Rajesh, Lagu, Bharat, Harwell, Chris, Zhang, Yalin, Bauer, Daniel, Kelleher, Joseph F., Egan, William

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Sequences, Structural Models, and Cellular Localization of the Actin-Related Proteins Arp2 and Arp3 from Acanthamoeba von Kelleher, Joseph F., Atkinson, Simon J., Pollard, Thomas D.

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Arp2/3 complex from Acanthamoeba binds profilin and cross-links actin filaments von Mullins, R D, Kelleher, J F, Xu, J, Pollard, T D

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Intracellular motility: How can we all work together? von Kelleher, Joseph F, Titus, Margaret A

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Abstract LB-272: KYM-001, a first-in-class oral IRAK4 protein degrader, induces tumor regression in xenograft models of MYD88-mutant ABC DLBCL alone and in combination with BTK inh... von Kelleher, Joseph F., Campbell, Veronica, Chen, Jesse, Gollob, Jared, Ji, Nan, Kamadurai, Hari, Klaus, Christine, Li, Henry, Loh, Christine, McDonald, Alice, Rong, Haojing, Rusin, Scott, Sharma, Kirti, Vigil, Dominico, Walker, Duncan, Weiss, Matt, Yuan, Karen, Zhang, Yi, Audoly, Laurent, Mainolfi, Nello

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Myosin VI is required for asymmetric segregation of cellular components during C. elegans spermatogenesis von Kelleher, Joseph F., Mandell, Michael A., Moulder, Gary, Hill, Katherine L., L'Hernault, Steven W., Barstead, Robert, Titus, Margaret A.

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