An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer von Gouin, Kenneth H., Ing, Nathan, Plummer, Jasmine T., Rosser, Charles J., Ben Cheikh, Bassem, Oh, Catherine, Chen, Stephanie S., Chan, Keith Syson, Furuya, Hideki, Tourtellotte, Warren G., Knott, Simon R. V., Theodorescu, Dan

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Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors von Nikolos, Fotis, Hayashi, Kazukuni, Hoi, Xen Ping, Alonzo, Mark Ellie, Mo, Qianxing, Kasabyan, Armine, Furuya, Hideki, Trepel, Jane, Di Vizio, Dolores, Guarnerio, Jlenia, Theodorescu, Dan, Rosser, Charles, Apolo, Andrea, Galsky, Matthew, Chan, Keith Syson

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Impact of Stat3 activation upon skin biology: A dichotomy of its role between homeostasis and diseases von Sano, Shigetoshi, Chan, Keith Syson, DiGiovanni, John

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Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung von Lee, Yu-Cheng, Kurtova, Antonina V., Xiao, Jing, Nikolos, Fotis, Hayashi, Kazukuni, Tramel, Zoe, Jain, Antrix, Chen, Fengju, Chokshi, Mithil, Lee, Ciaran, Bao, Gang, Zhang, Xiang, Shen, Jianjun, Mo, Qianxing, Jung, Sung Yun, Rowley, David, Chan, Keith Syson

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Molecular Pathways: Targeting Cancer Stem Cells Awakened by Chemotherapy to Abrogate Tumor Repopulation von Chan, Keith Syson

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Integrative multi-omics analysis of muscle-invasive bladder cancer identifies prognostic biomarkers for frontline chemotherapy and immunotherapy von Mo, Qianxing, Li, Roger, Adeegbe, Dennis O., Peng, Guang, Chan, Keith Syson

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Prognostic Power of a Tumor Differentiation Gene Signature for Bladder Urothelial Carcinomas von Mo, Qianxing, Nikolos, Fotis, Chen, Fengju, Tramel, Zoe, Lee, Yu-Cheng, Hayashi, Kazukuni, Xiao, Jing, Shen, Jianjun, Chan, Keith Syson

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Stat3 Activation in Urothelial Stem Cells Leads to Direct Progression to Invasive Bladder Cancer von HO, Philip Levy, LAY, Erica Julianne, WEIGUO JIAN, PARRA, Diana, CHAN, Keith Syson

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Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells von Chan, Keith Syson, Espinosa, Inigo, Chao, Mark, Wong, David, Ailles, Laurie, Diehn, Max, Gill, Harcharan, Presti, Joseph Jr, Chang, Howard Y, van de Rijn, Matt, Shortliffe, Linda, Weissman, Irving L

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Understanding Drug Sensitivity and Tackling Resistance in Cancer von Tyner, Jeffrey W, Haderk, Franziska, Kumaraswamy, Anbarasu, Baughn, Linda B, Van Ness, Brian, Liu, Song, Marathe, Himangi, Alumkal, Joshi J, Bivona, Trever G, Chan, Keith Syson, Druker, Brian J, Hutson, Alan D, Nelson, Peter S, Sawyers, Charles L, Willey, Christopher D

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Metabolic targeting of cancer associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas von Broz, Marina T., Ko, Emily Y., Ishaya, Kristin, Xiao, Jinfen, De Simone, Marco, Hoi, Xen Ping, Piras, Roberta, Gala, Basia, Tessaro, Fernando H. G., Karlstaedt, Anja, Orsulic, Sandra, Lund, Amanda W., Chan, Keith Syson, Guarnerio, Jlenia

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circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment von Piras, Roberta, Ko, Emily Y., Barrett, Connor, De Simone, Marco, Lin, Xianzhi, Broz, Marina T., Tessaro, Fernando H. G., Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Goodridge, Helen S., Di Vizio, Dolores, Batish, Mona, Lawrenson, Kate, Chen, Y. Grace, Chan, Keith Syson, Guarnerio, Jlenia

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Cellular Hierarchy as a Determinant of Tumor Sensitivity to Chemotherapy von Rodriguez-Brenes, Ignacio A, Kurtova, Antonina V, Lin, Christopher, Lee, Yu-Cheng, Xiao, Jing, Mims, Martha, Chan, Keith Syson, Wodarz, Dominik

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Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis von Chan, Keith Syson, Sano, Shigetoshi, Kiguchi, Kaoru, Anders, Joanne, Komazawa, Nobuyasu, Takeda, Junji, DiGiovanni, John

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DNA vaccines against GPRC5D synergize with PD-1 blockade to treat multiple myeloma von Neeli, Praveen, Maza, Perry Ayn Mayson A., Chai, Dafei, Zhao, Dan, Hoi, Xen Ping, Chan, Keith Syson, Young, Ken H., Li, Yong

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1432 Cancer-associated fibroblasts metabolic targeting overcomes T-cell exclusion and chemoresistance von Broz, Marina, Ko, Emily, Ishaya, Kristin, Xiao, Jinfen, DeSimone, Marco, Xen Ping Hoi, Piras, Roberta, Gala, Basia, Fernando HG Tessaro, Orsulic, Sandra, Balzer, Bonnie, Chan, Keith Syson, Guarnerio, Jlenia

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Epidermal growth factor receptor-mediated activation of Stat3 during multistage skin carcinogenesis von CHAN, Keith Syson, CARBAJAL, Steve, KIGUCHI, Kaoru, CLIFFORD, John, SANO, Shigetoshi, DIGIOVANNI, John

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Abstract IA09: Collagen microenvironment in the modulation of local invasion and distal metastasis von Cheng, Yu, Chan, Keith Syson

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Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation von SANO, Shigetoshi, KEITH SYSON CHAN, MORI, Toshio, HANAOKA, Fumio, TAKEDA, Junji, DIGIOVANNI, John, KIRA, Masahiro, KATAOKA, Ken, TAKAGI, Satoshi, TARUTANI, Masahito, ITAMI, Satoshi, KIGUCHI, Kaoru, YOKOI, Masayuki, SUGASAWA, Kaoru

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Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance von Kurtova, Antonina V., Xiao, Jing, Mo, Qianxing, Pazhanisamy, Senthil, Krasnow, Ross, Lerner, Seth P., Chen, Fengju, Roh, Terrence T., Lay, Erica, Ho, Philip Levy, Chan, Keith Syson

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